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Mutant Htt interacts with Ku70, impairs DNA-dependent protein kinase function in nonhomologous end joining, and consequently increases DSB accumulation. Expression of exogenous Ku70 rescues abnormal behavior and pathological phenotypes in the R6\/2 mouse model of Huntington\u2019s disease (HD). These results collectively suggest that Ku70 is a critical regulator of DNA damage in HD pathology.<\/jats:p>","DOI":"10.1083\/jcb.200905138","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T22:41:49Z","timestamp":1272926509000},"page":"425-443","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":136,"title":["Mutant huntingtin impairs Ku70-mediated DNA repair"],"prefix":"10.1083","volume":"189","author":[{"given":"Yasushi","family":"Enokido","sequence":"first","affiliation":[{"name":"Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan 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