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Here, we characterize this relationship and demonstrate that Smn activity regulates the expression of FGF signaling components and thus FGF signaling. Furthermore, we show that alterations in FGF signaling activity are able to modify the neuromuscular junction defects caused by loss of Smn function and that muscle-specific activation of FGF is sufficient to rescue Smn-associated abnormalities.<\/jats:p>","DOI":"10.1083\/jcb.201004016","type":"journal-article","created":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T19:20:30Z","timestamp":1297106430000},"page":"481-495","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Modeling spinal muscular atrophy in <i>Drosophila<\/i> links <i>Smn<\/i> to FGF signaling"],"prefix":"10.1083","volume":"192","author":[{"given":"Anindya","family":"Sen","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takakazu","family":"Yokokura","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Kankel","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas N.","family":"Dimlich","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Manent","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhabrata","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Emory University, Atlanta, GA 30322 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Artavanis-Tsakonas","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, Boston, MA 02115 1"},{"name":"Coll\u00e8ge de France, Paris 75005, France 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2011,2,7]]},"reference":[{"key":"2023072300530141600_bib1","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1172\/JCI22922","article-title":"Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy","volume":"114","author":"Azzouz","year":"2004","journal-title":"J. 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