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The FCM-specific actin focus invades the apposing founder cell with multiple finger-like protrusions, leading to the formation of a single-channel macro fusion pore between the two muscle cells. Two actin nucleation\u2013promoting factors of the Arp2\/3 complex, WASP and Scar, are required for the formation of the F-actin foci, whereas WASP but not Scar promotes efficient foci invasion. Our studies uncover a novel invasive podosome-like structure (PLS) in a developing tissue and reveal a previously unrecognized function of PLSs in facilitating cell membrane juxtaposition and fusion.<\/jats:p>","DOI":"10.1083\/jcb.201006006","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T04:14:17Z","timestamp":1290485657000},"page":"1013-1027","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":215,"title":["An invasive podosome-like structure promotes fusion pore formation during myoblast fusion"],"prefix":"10.1083","volume":"191","author":[{"given":"Kristin L.","family":"Sens","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Bioengineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD 20892 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengbao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Parachini","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,11,22]]},"reference":[{"key":"2023072300340272700_bib1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/978-1-59745-250-2_5","article-title":"Myoblast fusion in Drosophila","volume":"475","author":"Abmayr","year":"2008","journal-title":"Methods Mol. 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