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The mechanisms that connect the underlying genetic defects to disease pathogenesis are poorly understood, but their exploration is shedding new light on interesting cell biological processes and suggesting novel therapeutic targets.<\/jats:p>","DOI":"10.1083\/jcb.201006173","type":"journal-article","created":{"date-parts":[[2010,11,15]],"date-time":"2010-11-15T23:16:24Z","timestamp":1289862984000},"page":"701-710","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":248,"title":["The cell biology of polycystic kidney disease"],"prefix":"10.1083","volume":"191","author":[{"given":"Hannah C.","family":"Chapin","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Caplan","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,11,15]]},"reference":[{"key":"2023072301471717100_bib1","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/ki.2008.246","article-title":"KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease","volume":"74","author":"Albaqumi","year":"2008","journal-title":"Kidney Int."},{"key":"2023072301471717100_bib2","doi-asserted-by":"publisher","first-page":"6454","DOI":"10.1073\/pnas.0610324104","article-title":"Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2","volume":"104","author":"Anyatonwu","year":"2007","journal-title":"Proc. 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