{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:16:12Z","timestamp":1790550972836,"version":"4.1.0"},"reference-count":57,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:p>Retrograde bone morphogenetic protein signaling mediated by the Glass bottom boat (Gbb) ligand modulates structural and functional synaptogenesis at the Drosophila melanogaster neuromuscular junction. However, the molecular mechanisms regulating postsynaptic Gbb release are poorly understood. In this study, we show that Drosophila Rich (dRich), a conserved Cdc42-selective guanosine triphosphatase\u2013activating protein (GAP), inhibits the Cdc42\u2013Wsp pathway to stimulate postsynaptic Gbb release. Loss of dRich causes synaptic undergrowth and strongly impairs neurotransmitter release. These presynaptic defects are rescued by targeted postsynaptic expression of wild-type dRich but not a GAP-deficient mutant. dRich inhibits the postsynaptic localization of the Cdc42 effector Wsp (Drosophila orthologue of mammalian Wiskott-Aldrich syndrome protein, WASp), and manifestation of synaptogenesis defects in drich mutants requires Wsp signaling. In addition, dRich regulates postsynaptic organization independently of Cdc42. Importantly, dRich increases Gbb release and elevates presynaptic phosphorylated Mad levels. We propose that dRich coordinates the Gbb-dependent modulation of synaptic growth and function with postsynaptic development.<\/jats:p>","DOI":"10.1083\/jcb.201007086","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T15:38:17Z","timestamp":1288625897000},"page":"661-675","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["The Cdc42-selective GAP Rich regulates postsynaptic development and retrograde BMP transsynaptic signaling"],"prefix":"10.1083","volume":"191","author":[{"given":"Minyeop","family":"Nahm","sequence":"first","affiliation":[{"name":"Interdisplinary Program in Brain Science 1 and 2"},{"name":"Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul 110-740, Republic of Korea 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Ashleigh","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology 3 and 4"},{"name":"Department of Biological Sciences, Brain Institute, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232 3 and 4"},{"name":"Department of Cell and Developmental Biology 3 and 4"},{"name":"Department of Biological Sciences, Brain Institute, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232 3 and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Kyoo","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 700-412, Republic of Korea 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungdae","family":"Kim","sequence":"additional","affiliation":[{"name":"Interdisplinary Program in Brain Science 1 and 2"},{"name":"Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul 110-740, Republic of Korea 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Chul","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 700-412, Republic of Korea 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendal","family":"Broadie","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology 3 and 4"},{"name":"Department of Biological Sciences, Brain Institute, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232 3 and 4"},{"name":"Department of Cell and Developmental Biology 3 and 4"},{"name":"Department of Biological Sciences, Brain Institute, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232 3 and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungbok","family":"Lee","sequence":"additional","affiliation":[{"name":"Interdisplinary Program in Brain Science 1 and 2"},{"name":"Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul 110-740, Republic of Korea 1 and 2"},{"name":"Interdisplinary Program in Brain Science 1 and 2"},{"name":"Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul 110-740, Republic of Korea 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,11,1]]},"reference":[{"key":"2023072303121382900_bib1","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0896-6273(02)00589-5","article-title":"wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila","volume":"33","author":"Aberle","year":"2002","journal-title":"Neuron."},{"key":"2023072303121382900_bib2","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1038\/ncb1305","article-title":"Abi activates WASP to promote sensory organ development","volume":"7","author":"Bogdan","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"2023072303121382900_bib3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development."},{"key":"2023072303121382900_bib4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/S0896-6273(00)80196-8","article-title":"Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg","volume":"17","author":"Budnik","year":"1996","journal-title":"Neuron."},{"key":"2023072303121382900_bib5","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0896-6273(04)00016-9","article-title":"Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila","volume":"41","author":"Coyle","year":"2004","journal-title":"Neuron."},{"key":"2023072303121382900_bib6","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1523\/JNEUROSCI.19-08-03023.1999","article-title":"Glutamate receptor expression regulates quantal size and quantal content at the Drosophila neuromuscular junction","volume":"19","author":"DiAntonio","year":"1999","journal-title":"J. Neurosci."},{"key":"2023072303121382900_bib7","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1523\/JNEUROSCI.4201-04.2005","article-title":"An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction","volume":"25","author":"Featherstone","year":"2005","journal-title":"J. Neurosci."},{"key":"2023072303121382900_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1083\/jcb.200812150","article-title":"Maturation of active zone assembly by Drosophila Bruchpilot","volume":"186","author":"Fouquet","year":"2009","journal-title":"J. Cell Biol."},{"key":"2023072303121382900_bib9","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/j.cub.2009.07.058","article-title":"Drosophila Cip4\/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR\/WAVE","volume":"19","author":"Fricke","year":"2009","journal-title":"Curr. Biol."},{"key":"2023072303121382900_bib10","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.cell.2007.12.041","article-title":"Structural basis of membrane invagination by F-BAR domains","volume":"132","author":"Frost","year":"2008","journal-title":"Cell."},{"key":"2023072303121382900_bib11","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1242\/dev.022244","article-title":"Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure","volume":"135","author":"Gatto","year":"2008","journal-title":"Development."},{"key":"2023072303121382900_bib12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.neuron.2007.08.006","article-title":"The BMP ligand Gbb gates the expression of synaptic homeostasis independent of synaptic growth control","volume":"56","author":"Goold","year":"2007","journal-title":"Neuron."},{"key":"2023072303121382900_bib13","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S0960-9822(09)00451-5","article-title":"The Drosophila tumor suppressor gene, dlg, is involved in structural plasticity at a glutamatergic synapse","volume":"6","author":"Guan","year":"1996","journal-title":"Curr. Biol."},{"key":"2023072303121382900_bib14","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0896-6273(03)00427-6","article-title":"Retrograde control of synaptic transmission by postsynaptic CaMKII at the Drosophila neuromuscular junction","volume":"39","author":"Haghighi","year":"2003","journal-title":"Neuron."},{"key":"2023072303121382900_bib15","doi-asserted-by":"publisher","first-page":"36885","DOI":"10.1074\/jbc.M004069200","article-title":"Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis","volume":"275","author":"Harada","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2023072303121382900_bib16","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/genetics\/139.4.1701","article-title":"A genetic analysis of the 63E-64A genomic region of Drosophila melanogaster: identification of mutations in a replication factor C subunit","volume":"139","author":"Harrison","year":"1995","journal-title":"Genetics."},{"key":"2023072303121382900_bib17","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1073\/pnas.79.8.2700","article-title":"Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos","volume":"79","author":"Jan","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072303121382900_bib18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.tins.2004.01.004","article-title":"Orchestrating development and function: retrograde BMP signaling in the Drosophila nervous system","volume":"27","author":"Keshishian","year":"2004","journal-title":"Trends Neurosci."},{"key":"2023072303121382900_bib19","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1091\/mbc.E08-10-1072","article-title":"Syndapin promotes formation of a postsynaptic membrane system in Drosophila","volume":"20","author":"Kumar","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"2023072303121382900_bib20","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.ceb.2007.04.017","article-title":"Actin in membrane trafficking","volume":"19","author":"Lanzetti","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072303121382900_bib21","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/ng1513","article-title":"Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster","volume":"37","author":"Lee","year":"2005","journal-title":"Nat. Genet."},{"key":"2023072303121382900_bib22","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1242\/dev.02842","article-title":"The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion","volume":"134","author":"Lee","year":"2007","journal-title":"Development."},{"key":"2023072303121382900_bib23","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.ydbio.2009.03.019","article-title":"Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development","volume":"330","author":"Lee","year":"2009","journal-title":"Dev. Biol."},{"key":"2023072303121382900_bib24","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.cub.2008.09.063","article-title":"Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis","volume":"18","author":"Leibfried","year":"2008","journal-title":"Curr. Biol."},{"key":"2023072303121382900_bib25","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1741-7007-3-27","article-title":"Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants","volume":"3","author":"Liebl","year":"2005","journal-title":"BMC Biol."},{"key":"2023072303121382900_bib26","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/0896-6273(94)90022-1","article-title":"Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance","volume":"13","author":"Lin","year":"1994","journal-title":"Neuron."},{"key":"2023072303121382900_bib27","doi-asserted-by":"publisher","first-page":"3668","DOI":"10.1523\/JNEUROSCI.5553-07.2008","article-title":"Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein","volume":"28","author":"Long","year":"2008","journal-title":"J. Neurosci."},{"key":"2023072303121382900_bib28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0074-7742(06)75012-7","article-title":"Retrograde signaling that regulates synaptic development and function at the Drosophila neuromuscular junction","volume":"75","author":"Marqu\u00e9s","year":"2006","journal-title":"Int. Rev. Neurobiol."},{"key":"2023072303121382900_bib29","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0896-6273(02)00595-0","article-title":"The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function","volume":"33","author":"Marqu\u00e9s","year":"2002","journal-title":"Neuron."},{"key":"2023072303121382900_bib30","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1523\/JNEUROSCI.1575-03.2004","article-title":"Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction","volume":"24","author":"Marrus","year":"2004","journal-title":"J. Neurosci."},{"key":"2023072303121382900_bib31","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0896-6273(03)00426-4","article-title":"The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction","volume":"39","author":"McCabe","year":"2003","journal-title":"Neuron."},{"key":"2023072303121382900_bib32","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0896-6273(04)00073-X","article-title":"Highwire regulates presynaptic BMP signaling essential for synaptic growth","volume":"41","author":"McCabe","year":"2004","journal-title":"Neuron."},{"key":"2023072303121382900_bib33","doi-asserted-by":"publisher","first-page":"8138","DOI":"10.1523\/JNEUROSCI.0256-10.2010","article-title":"dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal","volume":"30","author":"Nahm","year":"2010","journal-title":"J. Neurosci."},{"key":"2023072303121382900_bib34","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.neuron.2008.03.007","article-title":"Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth","volume":"58","author":"O\u2019Connor-Giles","year":"2008","journal-title":"Neuron."},{"key":"2023072303121382900_bib35","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/S0896-6273(00)80415-8","article-title":"Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release","volume":"19","author":"Petersen","year":"1997","journal-title":"Neuron."},{"key":"2023072303121382900_bib36","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1083\/jcb.200607036","article-title":"A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction","volume":"175","author":"Pielage","year":"2006","journal-title":"J. Cell Biol."},{"key":"2023072303121382900_bib37","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1523\/JNEUROSCI.4194-04.2005","article-title":"Four different subunits are essential for expressing the synaptic glutamate receptor at neuromuscular junctions of Drosophila","volume":"25","author":"Qin","year":"2005","journal-title":"J. Neurosci."},{"key":"2023072303121382900_bib38","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/neu.10189","article-title":"Drosophila neuromuscular synapse assembly and function require the TGF-beta type I receptor saxophone and the transcription factor Mad","volume":"55","author":"Rawson","year":"2003","journal-title":"J. Neurobiol."},{"key":"2023072303121382900_bib39","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1101\/gad.207801","article-title":"Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila","volume":"15","author":"Razzaq","year":"2001","journal-title":"Genes Dev."},{"key":"2023072303121382900_bib40","doi-asserted-by":"publisher","first-page":"35060","DOI":"10.1074\/jbc.M103540200","article-title":"Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1","volume":"276","author":"Richnau","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023072303121382900_bib41","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.bbrc.2004.05.221","article-title":"RICH-1 has a BIN\/Amphiphysin\/Rvsp domain responsible for binding to membrane lipids and tubulation of liposomes","volume":"320","author":"Richnau","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072303121382900_bib42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/genetics\/118.3.461","article-title":"A stable genomic source of P element transposase in Drosophila melanogaster","volume":"118","author":"Robertson","year":"1988","journal-title":"Genetics."},{"key":"2023072303121382900_bib43","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/neu.480220503","article-title":"Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development","volume":"22","author":"Robinow","year":"1991","journal-title":"J. Neurobiol."},{"key":"2023072303121382900_bib44","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0896-6273(00)80753-9","article-title":"latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity","volume":"23","author":"Rohrbough","year":"1999","journal-title":"Neuron."},{"key":"2023072303121382900_bib45","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nn.2122","article-title":"Activity-dependent site-specific changes of glutamate receptor composition in vivo","volume":"11","author":"Schmid","year":"2008","journal-title":"Nat. Neurosci."},{"key":"2023072303121382900_bib46","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/BF00215114","article-title":"Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions","volume":"175","author":"Stewart","year":"1994","journal-title":"J. Comp. Physiol. [A]."},{"key":"2023072303121382900_bib47","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0960-9822(00)00378-X","article-title":"Wingless gradient formation in the Drosophila wing","volume":"10","author":"Strigini","year":"2000","journal-title":"Curr. Biol."},{"key":"2023072303121382900_bib48","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0896-6273(02)01014-0","article-title":"Unrestricted synaptic growth in spinster\u2013a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation","volume":"36","author":"Sweeney","year":"2002","journal-title":"Neuron."},{"key":"2023072303121382900_bib49","doi-asserted-by":"publisher","first-page":"11009","DOI":"10.1073\/pnas.191351698","article-title":"Retrograde signaling at central synapses","volume":"98","author":"Tao","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072303121382900_bib50","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/neu.20017","article-title":"Cellular bases of activity-dependent paralysis in Drosophila stress-sensitive mutants","volume":"60","author":"Trotta","year":"2004","journal-title":"J. Neurobiol."},{"key":"2023072303121382900_bib51","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/39362","article-title":"Daughters against dpp modulates dpp organizing activity in Drosophila wing development","volume":"389","author":"Tsuneizumi","year":"1997","journal-title":"Nature."},{"key":"2023072303121382900_bib52","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.cell.2008.09.041","article-title":"Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells","volume":"135","author":"Venkatachalam","year":"2008","journal-title":"Cell."},{"key":"2023072303121382900_bib53","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nn1841","article-title":"Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules","volume":"10","author":"Wang","year":"2007","journal-title":"Nat. Neurosci."},{"key":"2023072303121382900_bib54","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.cell.2006.02.045","article-title":"A Rich1\/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells","volume":"125","author":"Wells","year":"2006","journal-title":"Cell."},{"key":"2023072303121382900_bib55","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/genetics\/152.2.629","article-title":"Genetic analysis of the bone morphogenetic protein-related gene, gbb, identifies multiple requirements during Drosophila development","volume":"152","author":"Wharton","year":"1999","journal-title":"Genetics."},{"key":"2023072303121382900_bib56","doi-asserted-by":"publisher","first-page":"9557","DOI":"10.1523\/JNEUROSCI.2532-05.2005","article-title":"Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements","volume":"25","author":"Wu","year":"2005","journal-title":"J. Neurosci."},{"key":"2023072303121382900_bib57","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1242\/dev.128.24.5005","article-title":"Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis","volume":"128","author":"Zelhof","year":"2001","journal-title":"Development."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/191\/3\/661\/1577985\/jcb_201007086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/191\/3\/661\/1577985\/jcb_201007086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T03:12:49Z","timestamp":1690081969000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/191\/3\/661\/36059\/The-Cdc42-selective-GAP-Rich-regulates"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,1]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,11,1]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201007086","relation":{},"ISSN":["1540-8140","0021-9525"],"issn-type":[{"value":"1540-8140","type":"electronic"},{"value":"0021-9525","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11,1]]}}}