{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:42:48Z","timestamp":1791236568311,"version":"4.1.0"},"reference-count":31,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,1,24]]},"abstract":"<jats:p>DNA polymerase \u03b7 (pol\u03b7) belongs to the Y-family of DNA polymerases and facilitates translesion synthesis past UV damage. We show that, after UV irradiation, pol\u03b7 becomes phosphorylated at Ser601 by the ataxia-telangiectasia mutated and Rad3-related (ATR) kinase. DNA damage\u2013induced phosphorylation of pol\u03b7 depends on its physical interaction with Rad18 but is independent of PCNA monoubiquitination. It requires the ubiquitin-binding domain of pol\u03b7 but not its PCNA-interacting motif. ATR-dependent phosphorylation of pol\u03b7 is necessary to restore normal survival and postreplication repair after ultraviolet irradiation in xeroderma pigmentosum variant fibroblasts, and is involved in the checkpoint response to UV damage. Taken together, our results provide evidence for a link between DNA damage\u2013induced checkpoint activation and translesion synthesis in mammalian cells.<\/jats:p>","DOI":"10.1083\/jcb.201008076","type":"journal-article","created":{"date-parts":[[2011,1,18]],"date-time":"2011-01-18T03:59:07Z","timestamp":1295323147000},"page":"219-227","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["ATR-mediated phosphorylation of DNA polymerase \u03b7 is needed for efficient recovery from UV damage"],"prefix":"10.1083","volume":"192","author":[{"given":"Thomas","family":"G\u00f6hler","sequence":"first","affiliation":[{"name":"Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Sabbioneda","sequence":"additional","affiliation":[{"name":"Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Green","sequence":"additional","affiliation":[{"name":"Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2011,1,17]]},"reference":[{"key":"2023072302063574300_bib1","doi-asserted-by":"publisher","first-page":"17724","DOI":"10.1073\/pnas.0809844105","article-title":"Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis","volume":"105","author":"Acharya","year":"2008","journal-title":"Proc. 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