{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:56:05Z","timestamp":1789869365762,"version":"4.0.1"},"reference-count":45,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,1,24]]},"abstract":"<jats:p>During peripheral nerve myelination, Schwann cells sort larger axons, ensheath them, and eventually wrap their membrane to form the myelin sheath. These processes involve extensive changes in cell shape, but the exact mechanisms involved are still unknown. Neural Wiskott\u2013Aldrich syndrome protein (N-WASP) integrates various extracellular signals to control actin dynamics and cytoskeletal reorganization through activation of the Arp2\/3 complex. By generating mice lacking N-WASP in myelinating Schwann cells, we show that N-WASP is crucial for myelination. In N-WASP\u2013deficient nerves, Schwann cells sort and ensheath axons, but most of them fail to myelinate and arrest at the promyelinating stage. Yet, a limited number of Schwann cells form unusually short internodes, containing thin myelin sheaths, with the occasional appearance of myelin misfoldings. These data suggest that regulation of actin filament nucleation in Schwann cells by N-WASP is crucial for membrane wrapping, longitudinal extension, and myelination.<\/jats:p>","DOI":"10.1083\/jcb.201010013","type":"journal-article","created":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T12:34:24Z","timestamp":1295872464000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":72,"title":["N-WASP is required for membrane wrapping and myelination by Schwann cells"],"prefix":"10.1083","volume":"192","author":[{"given":"Nurit","family":"Novak","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered","family":"Bar","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Sabanay","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahar","family":"Frechter","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Jaegle","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, Netherlands 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott B.","family":"Snapper","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dies","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, Netherlands 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elior","family":"Peles","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2011,1,24]]},"reference":[{"key":"2023072302054254100_bib1","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1002\/glia.20505","article-title":"N-WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells-implications for axon ensheathment at myelination","volume":"55","author":"Bacon","year":"2007","journal-title":"Glia."},{"key":"2023072302054254100_bib2","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1002\/glia.20885","article-title":"Role of the oligodendroglial cytoskeleton in differentiation and myelination","volume":"57","author":"Bauer","year":"2009","journal-title":"Glia."},{"key":"2023072302054254100_bib3","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1083\/jcb.200610108","article-title":"Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development","volume":"177","author":"Benninger","year":"2007","journal-title":"J. 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