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In this paper, we show that AurA is abundant in normal kidney tissue but is also abnormally expressed and activated in cells lining PKD-associated renal cysts. PKD arises from mutations in the PKD1 or PKD2 genes, encoding polycystins 1 and 2 (PC1 and PC2). AurA binds, phosphorylates, and reduces the activity of PC2, a Ca2+-permeable nonselective cation channel and, thus, limits the amplitude of Ca2+ release from the endoplasmic reticulum. These and other findings suggest AurA may be a relevant new biomarker or target in the therapy of PKD.<\/jats:p>","DOI":"10.1083\/jcb.201012061","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T20:58:11Z","timestamp":1307998691000},"page":"1021-1032","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Aurora A kinase activity influences calcium signaling in kidney cells"],"prefix":"10.1083","volume":"193","author":[{"given":"Olga V.","family":"Plotnikova","sequence":"first","affiliation":[{"name":"Department of Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena N.","family":"Pugacheva","sequence":"additional","affiliation":[{"name":"Department of Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica A.","family":"Golemis","sequence":"additional","affiliation":[{"name":"Department of Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2011,6,13]]},"reference":[{"key":"2023072301162882000_bib1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S1535-6108(02)00235-0","article-title":"AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol","volume":"3","author":"Anand","year":"2003","journal-title":"Cancer Cell."},{"key":"2023072301162882000_bib2","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.bbrc.2004.08.043","article-title":"Calcium signaling and polycystin-2","volume":"322","author":"Anyatonwu","year":"2004","journal-title":"Biochem. 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