{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:33:11Z","timestamp":1791178391984,"version":"4.1.0"},"reference-count":84,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,5,16]]},"abstract":"<jats:p>Intestinal stem cells (ISCs) in the adult Drosophila melanogaster midgut can respond to damage and support repair. We demonstrate in this paper that the tuberous sclerosis complex (TSC) plays a critical role in balancing ISC growth and division. Previous studies have shown that imaginal disc cells that are mutant for TSC have increased rates of growth and division. However, we report in this paper that loss of TSC in the adult Drosophila midgut results in the formation of much larger ISCs that have halted cell division. These mutant ISCs expressed proper stem cell markers, did not differentiate, and had defects in multiple steps of the cell cycle. Slowing the growth by feeding rapamycin or reducing Myc was sufficient to rescue the division defect. The TSC mutant guts had a thinner epithelial structure than wild-type tissues, and the mutant flies were more susceptible to tissue damage. Therefore, we have uncovered a context-dependent phenotype of TSC mutants in adult ISCs, such that the excessive growth leads to inhibition of division.<\/jats:p>","DOI":"10.1083\/jcb.201103018","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T06:00:43Z","timestamp":1305007243000},"page":"695-710","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["Tuberous sclerosis complex and Myc coordinate the growth and division of<i>Drosophila<\/i>intestinal stem cells"],"prefix":"10.1083","volume":"193","author":[{"given":"Alla","family":"Amcheslavsky","sequence":"first","affiliation":[{"name":"Program in Molecular Medicine 1 , 2 , and 3"},{"name":"Program in Cell Dynamics 1 , 2 , and 3"},{"name":"Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Ito","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine 1 , 2 , and 3"},{"name":"Program in Cell Dynamics 1 , 2 , and 3"},{"name":"Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology 4 and 5"},{"name":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 4 and 5"},{"name":"Department of Developmental Biology 4 and 5"},{"name":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 4 and 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Tony","family":"Ip","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine 1 , 2 , and 3"},{"name":"Program in Cell Dynamics 1 , 2 , and 3"},{"name":"Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605 1 , 2 , and 3"},{"name":"Program in Molecular Medicine 1 , 2 , and 3"},{"name":"Program in Cell Dynamics 1 , 2 , and 3"},{"name":"Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605 1 , 2 , and 3"},{"name":"Program in Molecular Medicine 1 , 2 , and 3"},{"name":"Program in Cell Dynamics 1 , 2 , and 3"},{"name":"Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2011,5,9]]},"reference":[{"key":"2023072302292771300_bib1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.stem.2008.10.016","article-title":"Tissue damage-induced intestinal stem cell division in Drosophila","volume":"4","author":"Amcheslavsky","year":"2009","journal-title":"Cell Stem Cell."},{"key":"2023072302292771300_bib2","doi-asserted-by":"publisher","first-page":"20883","DOI":"10.1073\/pnas.0911797106","article-title":"Synergy between bacterial infection and genetic predisposition in intestinal dysplasia","volume":"106","author":"Apidianakis","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072302292771300_bib3","doi-asserted-by":"publisher","first-page":"6361","DOI":"10.1038\/sj.onc.1209882","article-title":"Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase","volume":"25","author":"Avruch","year":"2006","journal-title":"Oncogene."},{"key":"2023072302292771300_bib4","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1242\/dev.039404","article-title":"Transcriptional control of stem cell maintenance in the Drosophila intestine","volume":"137","author":"Bardin","year":"2010","journal-title":"Development."},{"key":"2023072302292771300_bib5","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature."},{"key":"2023072302292771300_bib6","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1101\/gad.1674008","article-title":"The intestinal stem cell","volume":"22","author":"Barker","year":"2008","journal-title":"Genes Dev."},{"key":"2023072302292771300_bib7","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/nature07602","article-title":"Crypt stem cells as the cells-of-origin of intestinal cancer","volume":"457","author":"Barker","year":"2009","journal-title":"Nature."},{"key":"2023072302292771300_bib8","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/ng0708-818","article-title":"A new identity for the elusive intestinal stem cell","volume":"40","author":"Batlle","year":"2008","journal-title":"Nat. Genet."},{"key":"2023072302292771300_bib9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ydbio.2009.10.045","article-title":"JAK\/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage","volume":"338","author":"Beebe","year":"2010","journal-title":"Dev. Biol."},{"key":"2023072302292771300_bib10","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1242\/dev.056671","article-title":"EGF signaling regulates the proliferation of intestinal stem cells in Drosophila","volume":"138","author":"Biteau","year":"2011","journal-title":"Development."},{"key":"2023072302292771300_bib11","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.stem.2008.07.024","article-title":"JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut","volume":"3","author":"Biteau","year":"2008","journal-title":"Cell Stem Cell."},{"key":"2023072302292771300_bib12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/jcp.21866","article-title":"Stem cell pluripotency: a cellular trait that depends on transcription factors, chromatin state and a checkpoint deficient cell cycle","volume":"221","author":"Boheler","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"2023072302292771300_bib13","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: a simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023072302292771300_bib14","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1101\/gad.1827009","article-title":"Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila","volume":"23","author":"Buchon","year":"2009","journal-title":"Genes Dev."},{"key":"2023072302292771300_bib15","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.chom.2009.01.003","article-title":"Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation","volume":"5","author":"Buchon","year":"2009","journal-title":"Cell Host Microbe."},{"key":"2023072302292771300_bib16","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1741-7007-8-152","article-title":"Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection","volume":"8","author":"Buchon","year":"2010","journal-title":"BMC Biol."},{"key":"2023072302292771300_bib17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1126\/science.1165678","article-title":"Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny","volume":"323","author":"Buszczak","year":"2009","journal-title":"Science."},{"key":"2023072302292771300_bib18","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.stem.2009.01.009","article-title":"Intestinal stem cells in mammals and Drosophila","volume":"4","author":"Casali","year":"2009","journal-title":"Cell Stem Cell."},{"key":"2023072302292771300_bib19","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/jcp.21808","article-title":"Pathogenic stimulation of intestinal stem cell response in Drosophila","volume":"220","author":"Chatterjee","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"2023072302292771300_bib20","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/j.1474-9726.2008.00380.x","article-title":"Age-related changes in Drosophila midgut are associated with PVF2, a PDGF\/VEGF-like growth factor","volume":"7","author":"Choi","year":"2008","journal-title":"Aging Cell."},{"key":"2023072302292771300_bib21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1535-7511.2008.00279.x","article-title":"Do we have a cure for tuberous sclerosis complex?","volume":"8","author":"Crino","year":"2008","journal-title":"Epilepsy Curr."},{"key":"2023072302292771300_bib22","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1126\/science.1173164","article-title":"Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection","volume":"325","author":"Cronin","year":"2009","journal-title":"Science."},{"key":"2023072302292771300_bib23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrg1840","article-title":"Organizing cell renewal in the intestine: stem cells, signals and combinatorial control","volume":"7","author":"Crosnier","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"2023072302292771300_bib24","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/labinvest.3780143","article-title":"Distribution of Tsc1 protein detected by immunohistochemistry in various normal rat tissues and the renal carcinomas of Eker rat: detection of limited colocalization with Tsc1 and Tsc2 gene products in vivo","volume":"80","author":"Fukuda","year":"2000","journal-title":"Lab. Invest."},{"key":"2023072302292771300_bib25","doi-asserted-by":"publisher","first-page":"19384","DOI":"10.1073\/pnas.0810584105","article-title":"mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization","volume":"105","author":"Gan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072302292771300_bib26","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1101\/gad.901101","article-title":"TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth","volume":"15","author":"Gao","year":"2001","journal-title":"Genes Dev."},{"key":"2023072302292771300_bib27","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1475-4924-2-5","article-title":"Controlling cell division in yeast and animals: does size matter?","volume":"2","author":"Grewal","year":"2003","journal-title":"J. Biol."},{"key":"2023072302292771300_bib28","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.devcel.2006.10.007","article-title":"Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1","volume":"11","author":"Guertin","year":"2006","journal-title":"Dev. Cell."},{"key":"2023072302292771300_bib29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.ccr.2008.12.017","article-title":"mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice","volume":"15","author":"Guertin","year":"2009","journal-title":"Cancer Cell."},{"key":"2023072302292771300_bib30","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1101\/gad.416307","article-title":"Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth","volume":"21","author":"Hietakangas","year":"2007","journal-title":"Genes Dev."},{"key":"2023072302292771300_bib31","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/00004836-199407000-00012","article-title":"Gastrointestinal involvement in tuberous sclerosis. Two case reports","volume":"19","author":"Hizawa","year":"1994","journal-title":"J. Clin. Gastroenterol."},{"key":"2023072302292771300_bib32","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1073\/pnas.0809144106","article-title":"Insulin levels control female germline stem cell maintenance via the niche in Drosophila","volume":"106","author":"Hsu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072302292771300_bib33","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/BJ20080281","article-title":"The TSC1-TSC2 complex: a molecular switchboard controlling cell growth","volume":"412","author":"Huang","year":"2008","journal-title":"Biochem. J."},{"key":"2023072302292771300_bib34","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1042\/BST0370217","article-title":"A complex interplay between Akt, TSC2 and the two mTOR complexes","volume":"37","author":"Huang","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"2023072302292771300_bib35","doi-asserted-by":"publisher","first-page":"6107","DOI":"10.1158\/0008-5472.CAN-09-0975","article-title":"Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors","volume":"69","author":"Huang","year":"2009","journal-title":"Cancer Res."},{"key":"2023072302292771300_bib36","doi-asserted-by":"publisher","first-page":"R94","DOI":"10.1093\/hmg\/ddp032","article-title":"Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment","volume":"18","author":"Inoki","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"2023072302292771300_bib37","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0092-8674(00)80657-1","article-title":"gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle","volume":"96","author":"Ito","year":"1999","journal-title":"Cell."},{"key":"2023072302292771300_bib38","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1242\/dev.026955","article-title":"EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors","volume":"136","author":"Jiang","year":"2009","journal-title":"Development."},{"key":"2023072302292771300_bib39","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.cell.2009.05.014","article-title":"Cytokine\/Jak\/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut","volume":"137","author":"Jiang","year":"2009","journal-title":"Cell."},{"key":"2023072302292771300_bib40","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.stem.2010.11.026","article-title":"EGFR\/Ras\/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila","volume":"8","author":"Jiang","year":"2011","journal-title":"Cell Stem Cell."},{"key":"2023072302292771300_bib41","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/modpathol.3880286","article-title":"Hamartin and tuberin expression in human tissues","volume":"14","author":"Johnson","year":"2001","journal-title":"Mod. Pathol."},{"key":"2023072302292771300_bib42","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S0092-8674(00)81512-3","article-title":"Drosophila myc regulates cellular growth during development","volume":"98","author":"Johnston","year":"1999","journal-title":"Cell."},{"key":"2023072302292771300_bib43","doi-asserted-by":"publisher","first-page":"R1014","DOI":"10.1016\/j.cub.2004.11.027","article-title":"How cells coordinate growth and division","volume":"14","author":"Jorgensen","year":"2004","journal-title":"Curr. Biol."},{"key":"2023072302292771300_bib44","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1242\/dev.060483","article-title":"The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration","volume":"137","author":"Karpowicz","year":"2010","journal-title":"Development."},{"key":"2023072302292771300_bib45","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.ceb.2008.10.002","article-title":"Proliferative control in Drosophila stem cells","volume":"20","author":"Kohlmaier","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072302292771300_bib46","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0166-2236(00)01791-4","article-title":"Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development","volume":"24","author":"Lee","year":"2001","journal-title":"Trends Neurosci."},{"key":"2023072302292771300_bib47","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1242\/dev.035196","article-title":"Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation","volume":"136","author":"Lee","year":"2009","journal-title":"Development."},{"key":"2023072302292771300_bib48","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.ceb.2005.09.008","article-title":"Controlling the size of organs and organisms","volume":"17","author":"Leevers","year":"2005","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072302292771300_bib49","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1126\/science.1180794","article-title":"Coexistence of quiescent and active adult stem cells in mammals","volume":"327","author":"Li","year":"2010","journal-title":"Science."},{"key":"2023072302292771300_bib50","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/nature07329","article-title":"Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells","volume":"455","author":"Lin","year":"2008","journal-title":"Nature."},{"key":"2023072302292771300_bib51","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/jmcb\/mjp028","article-title":"Paracrine unpaired signaling through the JAK\/STAT pathway controls self-renewal and lineage differentiation of Drosophila intestinal stem cells","volume":"2","author":"Lin","year":"2010","journal-title":"J. Mol. Cell Biol."},{"key":"2023072302292771300_bib52","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1101\/gad.5.12a.2153","article-title":"polo encodes a protein kinase homolog required for mitosis in Drosophila","volume":"5","author":"Llamazares","year":"1991","journal-title":"Genes Dev."},{"key":"2023072302292771300_bib53","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1111\/j.1365-2443.2008.01239.x","article-title":"E-cadherin prolongs the moment for interaction between intestinal stem cell and its progenitor cell to ensure Notch signaling in adult Drosophila midgut","volume":"13","author":"Maeda","year":"2008","journal-title":"Genes Cells."},{"key":"2023072302292771300_bib54","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1126\/science.1181958","article-title":"A transient niche regulates the specification of Drosophila intestinal stem cells","volume":"327","author":"Mathur","year":"2010","journal-title":"Science."},{"key":"2023072302292771300_bib55","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s00018-007-7427-x","article-title":"Skin stem and progenitor cells: using regeneration as a tissue-engineering strategy","volume":"65","author":"Metcalfe","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"2023072302292771300_bib56","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature04371","article-title":"Evidence that stem cells reside in the adult Drosophila midgut epithelium","volume":"439","author":"Micchelli","year":"2006","journal-title":"Nature."},{"key":"2023072302292771300_bib57","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1469-7580.2008.00925.x","article-title":"Small intestinal stem cell markers","volume":"213","author":"Montgomery","year":"2008","journal-title":"J. Anat."},{"key":"2023072302292771300_bib58","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2174\/157488806775269151","article-title":"Mesenchymal stem cell-based HLA-independent cell therapy for tissue engineering of bone and cartilage","volume":"1","author":"Niemeyer","year":"2006","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"2023072302292771300_bib59","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.gde.2006.08.003","article-title":"Breaking out of the mold: diversity within adult stem cells and their niches","volume":"16","author":"Nystul","year":"2006","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2023072302292771300_bib60","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/nature04333","article-title":"The adult Drosophila posterior midgut is maintained by pluripotent stem cells","volume":"439","author":"Ohlstein","year":"2006","journal-title":"Nature."},{"key":"2023072302292771300_bib61","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1126\/science.1136606","article-title":"Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling","volume":"315","author":"Ohlstein","year":"2007","journal-title":"Science."},{"key":"2023072302292771300_bib62","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.tcb.2003.12.006","article-title":"Tuberous sclerosis complex: from Drosophila to human disease","volume":"14","author":"Pan","year":"2004","journal-title":"Trends Cell Biol."},{"key":"2023072302292771300_bib63","doi-asserted-by":"crossref","first-page":"637","DOI":"10.18632\/aging.100054","article-title":"The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila","volume":"1","author":"Park","year":"2009","journal-title":"Aging (Albany NY)."},{"key":"2023072302292771300_bib64","doi-asserted-by":"publisher","first-page":"21064","DOI":"10.1073\/pnas.1012759107","article-title":"Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways","volume":"107","author":"Ren","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072302292771300_bib65","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mrrev.2006.03.001","article-title":"The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27","volume":"613","author":"Rosner","year":"2006","journal-title":"Mutat. Res."},{"key":"2023072302292771300_bib66","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1083\/jcb.200801153","article-title":"Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation","volume":"183","author":"Royou","year":"2008","journal-title":"J. Cell Biol."},{"key":"2023072302292771300_bib67","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.semcdb.2009.09.006","article-title":"The stem cell\u2014chromatin connection","volume":"20","author":"Sang","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"2023072302292771300_bib68","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/ng.165","article-title":"Bmi1 is expressed in vivo in intestinal stem cells","volume":"40","author":"Sangiorgi","year":"2008","journal-title":"Nat. Genet."},{"key":"2023072302292771300_bib69","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sarbassov","year":"2005","journal-title":"Science."},{"key":"2023072302292771300_bib70","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.4161\/cc.8.9.8215","article-title":"Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway","volume":"8","author":"Schmidt","year":"2009","journal-title":"Cell Cycle."},{"key":"2023072302292771300_bib71","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1053\/j.gastro.2008.01.079","article-title":"Current view: intestinal stem cells and signaling","volume":"134","author":"Scoville","year":"2008","journal-title":"Gastroenterology."},{"key":"2023072302292771300_bib72","doi-asserted-by":"publisher","first-page":"4147","DOI":"10.1242\/dev.052506","article-title":"The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration","volume":"137","author":"Shaw","year":"2010","journal-title":"Development."},{"key":"2023072302292771300_bib73","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1016-8478(23)13152-9","article-title":"Drosophila melanogaster: a model for the study of DNA damage checkpoint response","volume":"19","author":"Song","year":"2005","journal-title":"Mol. Cells."},{"key":"2023072302292771300_bib74","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.cub.2010.07.041","article-title":"Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation","volume":"20","author":"Staley","year":"2010","journal-title":"Curr. Biol."},{"key":"2023072302292771300_bib75","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0960-9822(00)00300-6","article-title":"Activating the DNA damage checkpoint in a developmental context","volume":"10","author":"Su","year":"2000","journal-title":"Curr. Biol."},{"key":"2023072302292771300_bib76","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1242\/dev.051466","article-title":"TSC1\/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation","volume":"137","author":"Sun","year":"2010","journal-title":"Development."},{"key":"2023072302292771300_bib77","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0092-8674(01)00332-4","article-title":"The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation","volume":"105","author":"Tapon","year":"2001","journal-title":"Cell."},{"key":"2023072302292771300_bib78","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cmet.2007.11.010","article-title":"Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila","volume":"7","author":"Teleman","year":"2008","journal-title":"Cell Metab."},{"key":"2023072302292771300_bib79","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/MOG.0b013e3282f4954f","article-title":"Deciphering the \u2018black box\u2019 of the intestinal stem cell niche: taking direction from other systems","volume":"24","author":"Walker","year":"2008","journal-title":"Curr. Opin. Gastroenterol."},{"key":"2023072302292771300_bib80","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S0955-0674(00)00154-X","article-title":"Cell-cycle checkpoint kinases: checking in on the cell cycle","volume":"12","author":"Walworth","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072302292771300_bib81","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1534\/genetics.109.110379","article-title":"Control of wing size and proportions by Drosophila myc","volume":"184","author":"Wu","year":"2010","journal-title":"Genetics."},{"key":"2023072302292771300_bib82","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s12015-006-0048-1","article-title":"The gastrointestinal tract stem cell niche","volume":"2","author":"Yen","year":"2006","journal-title":"Stem Cell Rev."},{"key":"2023072302292771300_bib83","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1172\/JCI28984","article-title":"PDGFRs are critical for PI3K\/Akt activation and negatively regulated by mTOR","volume":"117","author":"Zhang","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2023072302292771300_bib84","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nature07589","article-title":"Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation","volume":"457","author":"Zhu","year":"2009","journal-title":"Nature."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/193\/4\/695\/1574146\/jcb_201103018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/193\/4\/695\/1574146\/jcb_201103018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T16:49:36Z","timestamp":1712422176000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/193\/4\/695\/36693\/Tuberous-sclerosis-complex-and-Myc-coordinate-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,9]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,5,16]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201103018","relation":{},"ISSN":["1540-8140","0021-9525"],"issn-type":[{"value":"1540-8140","type":"electronic"},{"value":"0021-9525","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5,9]]}}}