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We show that DDB2 elicits unfolding of large-scale chromatin structure independently of the CRL4 ubiquitin ligase complex. Our data reveal a marked adenosine triphosphate (ATP)\u2013dependent reduction in the density of core histones in chromatin containing UV-induced DNA lesions, which strictly required functional DDB2 and involved the activity of poly(adenosine diphosphate [ADP]\u2013ribose) polymerase 1. Finally, we show that lesion recognition by XPC, but not DDB2, was strongly reduced in ATP-depleted cells and was regulated by the steady-state levels of poly(ADP-ribose) chains.<\/jats:p>","DOI":"10.1083\/jcb.201106074","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:55:17Z","timestamp":1334019317000},"page":"267-281","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":164,"title":["DDB2 promotes chromatin decondensation at UV-induced DNA damage"],"prefix":"10.1083","volume":"197","author":[{"given":"Martijn S.","family":"Luijsterburg","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institutet, S-17177 Stockholm, Sweden 1"},{"name":"Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lindh","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institutet, S-17177 Stockholm, Sweden 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Acs","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institutet, S-17177 Stockholm, Sweden 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mischa G.","family":"Vrouwe","sequence":"additional","affiliation":[{"name":"Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Pines","sequence":"additional","affiliation":[{"name":"Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haico","family":"van Attikum","sequence":"additional","affiliation":[{"name":"Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon H.","family":"Mullenders","sequence":"additional","affiliation":[{"name":"Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, Netherlands 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico P.","family":"Dantuma","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Karolinska Institutet, S-17177 Stockholm, Sweden 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2012,4,9]]},"reference":[{"key":"2023072302265962900_bib1","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/0092-8674(95)90289-9","article-title":"Mammalian DNA nucleotide excision repair reconstituted with purified protein components","volume":"80","author":"Aboussekhra","year":"1995","journal-title":"Cell."},{"key":"2023072302265962900_bib2","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1126\/science.1177321","article-title":"Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1","volume":"325","author":"Ahel","year":"2009","journal-title":"Science."},{"key":"2023072302265962900_bib3","doi-asserted-by":"publisher","first-page":"10298","DOI":"10.1158\/0008-5472.CAN-05-2295","article-title":"Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation","volume":"65","author":"Alekseev","year":"2005","journal-title":"Cancer Res."},{"key":"2023072302265962900_bib4","doi-asserted-by":"publisher","first-page":"7402","DOI":"10.1128\/MCB.01108-08","article-title":"Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage","volume":"28","author":"Alekseev","year":"2008","journal-title":"Mol. 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