{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:03:20Z","timestamp":1790816600245,"version":"4.1.0"},"reference-count":54,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,11,26]]},"abstract":"<jats:p>Inositol 1,4,5\u2032-triphosphate receptor II (IP3RII) calcium channel expression is increased in both hypertrophic failing human myocardium and experimentally induced models of the disease. The ectopic calcium released from these receptors induces pro-hypertrophic gene expression and may promote arrhythmias. Here, we show that IP3RII expression was constitutively restrained by the muscle-specific miRNA, miR-133a. During the hypertrophic response to pressure overload or neurohormonal stimuli, miR-133a down-regulation permitted IP3RII levels to increase, instigating pro-hypertrophic calcium signaling and concomitant pathological remodeling. Using a combination of in vivo and in vitro approaches, we demonstrated that IP3-induced calcium release (IICR) initiated the hypertrophy-associated decrease in miR-133a. In this manner, hypertrophic stimuli that engage IICR set a feed-forward mechanism in motion whereby IICR decreased miR-133a expression, further augmenting IP3RII levels and therefore pro-hypertrophic calcium release. Consequently, IICR can be considered as both an initiating event and a driving force for pathological remodeling.<\/jats:p>","DOI":"10.1083\/jcb.201111095","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T05:41:16Z","timestamp":1353390076000},"page":"783-798","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Mutual antagonism between IP3RII and miRNA-133a regulates calcium signals and cardiac hypertrophy"],"prefix":"10.1083","volume":"199","author":[{"given":"Faye M.","family":"Drawnel","sequence":"first","affiliation":[{"name":"Babraham Institute, Babraham, Cambridge CB22 3AT, England, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Wachten","sequence":"additional","affiliation":[{"name":"Babraham Institute, Babraham, Cambridge CB22 3AT, England, UK 1"},{"name":"Department of Molecular Sensory Systems, Center of Advanced European Studies and Research, 53175 Bonn, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery D.","family":"Molkentin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Maillet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Magnus","family":"Aronsen","sequence":"additional","affiliation":[{"name":"Institute for Experimental Medical Research, Faculty of Medicine, Oslo University Hospital, 0407 Oslo, Norway 4"},{"name":"Bj\u00f8rknes College, 0456 Oslo, Norway 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Swift","sequence":"additional","affiliation":[{"name":"Institute for Experimental Medical Research, Faculty of Medicine, Oslo University Hospital, 0407 Oslo, Norway 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivar","family":"Sjaastad","sequence":"additional","affiliation":[{"name":"Institute for Experimental Medical Research, Faculty of Medicine, Oslo University Hospital, 0407 Oslo, Norway 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Catalucci","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, 20089 Rozzano, Milan, Italy 7"},{"name":"Institute of Genetic and Biomedical Research, Milan Section, National Research Council, 20138 Milan, Italy 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Mikoshiba","sequence":"additional","affiliation":[{"name":"Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 531-0198, Japan 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Hisatsune","sequence":"additional","affiliation":[{"name":"Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 531-0198, Japan 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"Okkenhaug","sequence":"additional","affiliation":[{"name":"Babraham Institute, Babraham, Cambridge CB22 3AT, England, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Babraham Institute, Babraham, Cambridge CB22 3AT, England, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin D.","family":"Bootman","sequence":"additional","affiliation":[{"name":"Babraham Institute, Babraham, Cambridge CB22 3AT, England, UK 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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