{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:35:42Z","timestamp":1791228942965,"version":"4.1.0"},"reference-count":36,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,6,11]]},"abstract":"<jats:p>The extent and temporal characteristics of G protein\u2013coupled receptor (GPCR) signaling are shaped by the regulator of G protein signaling (RGS) proteins, which promote G protein deactivation. With hundreds of GPCRs and dozens of RGS proteins, compartmentalization plays a key role in establishing signaling specificity. However, the molecular details and mechanisms of this process are poorly understood. In this paper, we report that the R7 group of RGS regulators is controlled by interaction with two previously uncharacterized orphan GPCRs: GPR158 and GPR179. We show that GPR158\/179 recruited RGS complexes to the plasma membrane and augmented their ability to regulate GPCR signaling. The loss of GPR179 in a mouse model of night blindness prevented targeting of RGS to the postsynaptic compartment of bipolar neurons in the retina, illuminating the role of GPR179 in night vision. We propose that the interaction of RGS proteins with orphan GPCRs promotes signaling selectivity in G protein pathways.<\/jats:p>","DOI":"10.1083\/jcb.201202123","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T15:38:05Z","timestamp":1339429085000},"page":"711-719","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":102,"title":["GPR158\/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes"],"prefix":"10.1083","volume":"197","author":[{"given":"Cesare","family":"Orlandi","sequence":"first","affiliation":[{"name":"Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Posokhova","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Masuho","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Ray","sequence":"additional","affiliation":[{"name":"Department Biochemistry and Molecular Biology 2 and 3"},{"name":"Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40202 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazarul","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department Biochemistry and Molecular Biology 2 and 3"},{"name":"Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40202 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Gregg","sequence":"additional","affiliation":[{"name":"Department Biochemistry and Molecular Biology 2 and 3"},{"name":"Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40202 2 and 3"},{"name":"Department Biochemistry and Molecular Biology 2 and 3"},{"name":"Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40202 2 and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill A.","family":"Martemyanov","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2012,6,11]]},"reference":[{"key":"2023072305595967100_bib1","doi-asserted-by":"publisher","first-page":"14117","DOI":"10.1523\/JNEUROSCI.3884-07.2007","article-title":"Expression and localization of RGS9-2\/G 5\/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases","volume":"27","author":"Anderson","year":"2007","journal-title":"J. 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