{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:54:23Z","timestamp":1789786463247,"version":"4.0.1"},"reference-count":56,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10,29]]},"abstract":"<jats:p>Axonal maintenance, plasticity, and regeneration are influenced by signals from neighboring cells, in particular Schwann cells of the peripheral nervous system. Schwann cells produce neurotrophic factors, but the mechanisms by which ciliary neurotrophic factor (CNTF) and other neurotrophic molecules modify the axonal cytoskeleton are not well understood. In this paper, we show that activated signal transducer and activator of transcription-3 (STAT3), an intracellular mediator of the effects of CNTF and other neurotrophic cytokines, acts locally in axons of motoneurons to modify the tubulin cytoskeleton. Specifically, we show that activated STAT3 interacted with stathmin and inhibited its microtubule-destabilizing activity. Thus, ectopic CNTF-mediated activation of STAT3 restored axon elongation and maintenance in motoneurons from progressive motor neuronopathy mutant mice, a mouse model of motoneuron disease. This mechanism could also be relevant for other neurodegenerative diseases and provide a target for new therapies for axonal degeneration.<\/jats:p>","DOI":"10.1083\/jcb.201203109","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T21:35:57Z","timestamp":1351546557000},"page":"437-451","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":76,"title":["Local axonal function of STAT3 rescues axon degeneration in the <i>pmn<\/i> model of motoneuron disease"],"prefix":"10.1083","volume":"199","author":[{"given":"Bhuvaneish Thangaraj","family":"Selvaraj","sequence":"first","affiliation":[{"name":"Institute for Clinical Neurobiology 1 and 2"},{"name":"Institute of Anatomy and Cell Biology, University of Wuerzburg, 97078 Wuerzburg, Germany 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Frank","sequence":"additional","affiliation":[{"name":"Institute for Clinical Neurobiology 1 and 2"},{"name":"Institute of Anatomy and Cell Biology, University of Wuerzburg, 97078 Wuerzburg, Germany 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian L.P.","family":"Bender","sequence":"additional","affiliation":[{"name":"Institute for Clinical Neurobiology 1 and 2"},{"name":"Institute of Anatomy and Cell Biology, University of Wuerzburg, 97078 Wuerzburg, Germany 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Asan","sequence":"additional","affiliation":[{"name":"Institute for Clinical Neurobiology 1 and 2"},{"name":"Institute of Anatomy and Cell Biology, University of Wuerzburg, 97078 Wuerzburg, Germany 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sendtner","sequence":"additional","affiliation":[{"name":"Institute for Clinical Neurobiology 1 and 2"},{"name":"Institute of Anatomy and Cell Biology, University of Wuerzburg, 97078 Wuerzburg, Germany 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"2023072302553467500_bib1","doi-asserted-by":"publisher","first-page":"22718","DOI":"10.1074\/jbc.M111605200","article-title":"The effect of stathmin phosphorylation on microtubule assembly depends on tubulin critical concentration","volume":"277","author":"Amayed","year":"2002","journal-title":"J. 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