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We show that Ca2+ released from the ER can activate the NAADP pathway in two ways: first, by stimulating Ca2+-dependent NAADP synthesis; second, by activating NAADP-regulated channels. Moreover, the differential effects of EGTA and BAPTA (slow and fast Ca2+ chelators, respectively) suggest that the acidic organelles are preferentially activated by local microdomains of high Ca2+ at junctions between the ER and acidic organelles. Bidirectional organelle communication may have wider implications for endo-lysosomal function as well as the generation of Ca2+ oscillations and waves.<\/jats:p>","DOI":"10.1083\/jcb.201204078","type":"journal-article","created":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T23:59:49Z","timestamp":1363046389000},"page":"789-805","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":143,"title":["Bidirectional Ca2+ signaling occurs between the endoplasmic reticulum and acidic organelles"],"prefix":"10.1083","volume":"200","author":[{"given":"Anthony J.","family":"Morgan","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford OX1 3QT, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne C.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford OX1 3QT, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried K.T.Y.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford OX1 3QT, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford OX1 3QT, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Parrington","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford OX1 3QT, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant C.","family":"Churchill","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford OX1 3QT, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Galione","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Oxford, Oxford OX1 3QT, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2013,3,11]]},"reference":[{"key":"2023072303210405400_bib1","doi-asserted-by":"publisher","first-page":"14566","DOI":"10.1074\/jbc.273.23.14566","article-title":"Calcium signaling by cyclic ADP-ribose, NAADP, and inositol trisphosphate are involved in distinct functions in ascidian oocytes","volume":"273","author":"Albrieux","year":"1998","journal-title":"J. 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