{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:30:07Z","timestamp":1791351007459,"version":"4.3.1"},"reference-count":61,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,8,5]]},"abstract":"<jats:p>Mechanisms coordinating endosomal degradation and recycling are poorly understood, as are the cellular roles of microtubule (MT) severing. We show that cells lacking the MT-severing protein spastin had increased tubulation of and defective receptor sorting through endosomal tubular recycling compartments. Spastin required the ability to sever MTs and to interact with ESCRT-III (a complex controlling cargo degradation) proteins to regulate endosomal tubulation. Cells lacking IST1 (increased sodium tolerance 1), an endosomal sorting complex required for transport (ESCRT) component to which spastin binds, also had increased endosomal tubulation. Our results suggest that inclusion of IST1 into the ESCRT complex allows recruitment of spastin to promote fission of recycling tubules from the endosome. Thus, we reveal a novel cellular role for MT severing and identify a mechanism by which endosomal recycling can be coordinated with the degradative machinery. Spastin is mutated in the axonopathy hereditary spastic paraplegia. Zebrafish spinal motor axons depleted of spastin or IST1 also had abnormal endosomal tubulation, so we propose this phenotype is important for axonal degeneration.<\/jats:p>","DOI":"10.1083\/jcb.201211045","type":"journal-article","created":{"date-parts":[[2013,7,30]],"date-time":"2013-07-30T01:55:55Z","timestamp":1375149355000},"page":"527-543","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":174,"title":["An ESCRT\u2013spastin interaction promotes fission of recycling tubules from the endosome"],"prefix":"10.1083","volume":"202","author":[{"given":"Rachel","family":"Allison","sequence":"first","affiliation":[{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"},{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H.","family":"Lumb","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"},{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Fassier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 7224, Centre National de la Recherche Scientifique, 75252 Paris, Cedex 05, France 4"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U952, 75252 Paris, Cedex 05, France 5"},{"name":"Universit\u00e9 Pierre et Marie Curie, 75252 Paris, Cedex 05, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Connell","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"},{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ten Martin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 7224, Centre National de la Recherche Scientifique, 75252 Paris, Cedex 05, France 4"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U952, 75252 Paris, Cedex 05, France 5"},{"name":"Universit\u00e9 Pierre et Marie Curie, 75252 Paris, Cedex 05, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.J.","family":"Seaman","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"},{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil\u00e9","family":"Hazan","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche 7224, Centre National de la Recherche Scientifique, 75252 Paris, Cedex 05, France 4"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U952, 75252 Paris, Cedex 05, France 5"},{"name":"Universit\u00e9 Pierre et Marie Curie, 75252 Paris, Cedex 05, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"},{"name":"Department of Medical Genetics 1 , 2 , and 3"},{"name":"Department of Clinical Biochemistry 1 , 2 , and 3"},{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK 1 , 2 , and 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2013,7,29]]},"reference":[{"key":"2023072306041408000_bib1","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1091\/mbc.E08-05-0474","article-title":"Essential role of hIST1 in cytokinesis","volume":"20","author":"Agromayor","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"2023072306041408000_bib2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S1534-5807(02)00220-4","article-title":"Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting","volume":"3","author":"Babst","year":"2002","journal-title":"Dev. Cell."},{"key":"2023072306041408000_bib3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S1534-5807(02)00219-8","article-title":"Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body","volume":"3","author":"Babst","year":"2002","journal-title":"Dev. Cell."},{"key":"2023072306041408000_bib4","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1091\/mbc.E08-05-0475","article-title":"Biochemical analyses of human IST1 and its function in cytokinesis","volume":"20","author":"Bajorek","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"2023072306041408000_bib5","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/nsmb.1621","article-title":"Structural basis for ESCRT-III protein autoinhibition","volume":"16","author":"Bajorek","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2023072306041408000_bib6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrn2990","article-title":"Hereditary spastic paraplegias: membrane traffic and the motor pathway","volume":"12","author":"Blackstone","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"2023072306041408000_bib7","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ceb.2008.03.009","article-title":"Retromer","volume":"20","author":"Bonifacino","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072306041408000_bib8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.cell.2012.01.047","article-title":"Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains","volume":"149","author":"Boucrot","year":"2012","journal-title":"Cell."},{"key":"2023072306041408000_bib9","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1042\/BST0381397","article-title":"The ESCRT machinery: a cellular apparatus for sorting and scission","volume":"38","author":"Carlton","year":"2010","journal-title":"Biochem. Soc. Trans."},{"key":"2023072306041408000_bib10","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1016\/j.cub.2004.09.077","article-title":"Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides","volume":"14","author":"Carlton","year":"2004","journal-title":"Curr. Biol."},{"key":"2023072306041408000_bib11","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.yexcr.2005.06.009","article-title":"Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus","volume":"309","author":"Claudiani","year":"2005","journal-title":"Exp. Cell Res."},{"key":"2023072306041408000_bib12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1600-0854.2008.00847.x","article-title":"Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion","volume":"10","author":"Connell","year":"2009","journal-title":"Traffic."},{"key":"2023072306041408000_bib13","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.devcel.2009.09.010","article-title":"The Arp2\/3 activator WASH controls the fission of endosomes through a large multiprotein complex","volume":"17","author":"Derivery","year":"2009","journal-title":"Dev. Cell."},{"key":"2023072306041408000_bib14","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1083\/jcb.201112101","article-title":"Lis1 is an initiation factor for dynein-driven organelle transport","volume":"197","author":"Egan","year":"2012","journal-title":"J. Cell Biol."},{"key":"2023072306041408000_bib15","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1038\/nn.2662","article-title":"Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway","volume":"13","author":"Fassier","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2023072306041408000_bib16","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1242\/dmm.008946","article-title":"Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice","volume":"6","author":"Fassier","year":"2013","journal-title":"Dis. Model. Mech."},{"key":"2023072306041408000_bib17","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1242\/dev.02044","article-title":"Neuromuscular synapses can form in vivo by incorporation of initially aneural postsynaptic specializations","volume":"132","author":"Flanagan-Steet","year":"2005","journal-title":"Development."},{"key":"2023072306041408000_bib18","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.cell.2009.04.010","article-title":"The BAR domain superfamily: membrane-molding macromolecules","volume":"137","author":"Frost","year":"2009","journal-title":"Cell."},{"key":"2023072306041408000_bib19","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.devcel.2009.09.009","article-title":"A FAM21-containing WASH complex regulates retromer-dependent sorting","volume":"17","author":"Gomez","year":"2009","journal-title":"Dev. Cell."},{"key":"2023072306041408000_bib20","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1126\/science.1201847","article-title":"Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments","volume":"331","author":"Guizetti","year":"2011","journal-title":"Science."},{"key":"2023072306041408000_bib21","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.ceb.2009.06.002","article-title":"Cell biology of the ESCRT machinery","volume":"21","author":"Hanson","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072306041408000_bib22","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1242\/jcs.071472","article-title":"The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics","volume":"123","author":"Harbour","year":"2010","journal-title":"J. Cell Sci."},{"key":"2023072306041408000_bib23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/15472","article-title":"Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia","volume":"23","author":"Hazan","year":"1999","journal-title":"Nat. Genet."},{"key":"2023072306041408000_bib24","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.devcel.2011.05.015","article-title":"The ESCRT pathway","volume":"21","author":"Henne","year":"2011","journal-title":"Dev. Cell."},{"key":"2023072306041408000_bib25","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.cell.2012.08.039","article-title":"The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices","volume":"151","author":"Henne","year":"2012","journal-title":"Cell."},{"key":"2023072306041408000_bib26","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.cell.2009.05.025","article-title":"A class of dynamin-like GTPases involved in the generation of the tubular ER network","volume":"138","author":"Hu","year":"2009","journal-title":"Cell."},{"key":"2023072306041408000_bib27","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3109\/10409238.2010.502516","article-title":"The ESCRT complexes","volume":"45","author":"Hurley","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"2023072306041408000_bib28","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.devcel.2007.12.013","article-title":"MIT domainia","volume":"14","author":"Hurley","year":"2008","journal-title":"Dev. Cell."},{"key":"2023072306041408000_bib29","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/j.1600-0854.2011.01314.x","article-title":"Regulation of membrane protein degradation by starvation-response pathways","volume":"13","author":"Jones","year":"2012","journal-title":"Traffic."},{"key":"2023072306041408000_bib30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"2023072306041408000_bib31","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1083\/jcb.201004060","article-title":"SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane","volume":"190","author":"Lauffer","year":"2010","journal-title":"J. Cell Biol."},{"key":"2023072306041408000_bib32","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1038\/sj.emboj.7601119","article-title":"A dynein loading zone for retrograde endosome motility at microtubule plus-ends","volume":"25","author":"Lenz","year":"2006","journal-title":"EMBO J."},{"key":"2023072306041408000_bib33","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.bbamcr.2011.08.010","article-title":"The AAA ATPase spastin links microtubule severing to membrane modelling","volume":"1823","author":"Lumb","year":"2012","journal-title":"Biochim. Biophys. Acta."},{"key":"2023072306041408000_bib34","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm1315","article-title":"Endocytic recycling","volume":"5","author":"Maxfield","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023072306041408000_bib35","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1172\/JCI60560","article-title":"Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12","volume":"122","author":"Montenegro","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2023072306041408000_bib36","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1083\/jcb.200305145","article-title":"Clathrin-mediated endocytosis in AP-2\u2013depleted cells","volume":"162","author":"Motley","year":"2003","journal-title":"J. Cell Biol."},{"key":"2023072306041408000_bib37","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/j.1600-0854.2010.01035.x","article-title":"Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent","volume":"11","author":"Nisar","year":"2010","journal-title":"Traffic."},{"key":"2023072306041408000_bib38","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/nature06171","article-title":"Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4","volume":"449","author":"Obita","year":"2007","journal-title":"Nature."},{"key":"2023072306041408000_bib39","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1172\/JCI40979","article-title":"Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network","volume":"120","author":"Park","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2023072306041408000_bib40","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1091\/mbc.E03-12-0918","article-title":"The RCP-Rab11 complex regulates endocytic protein sorting","volume":"15","author":"Peden","year":"2004","journal-title":"Mol. Biol. Cell."},{"key":"2023072306041408000_bib41","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.cellbio.23.090506.123319","article-title":"Biogenesis and function of multivesicular bodies","volume":"23","author":"Piper","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2023072306041408000_bib42","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1242\/jcs.109.4.749","article-title":"The effect of wortmannin on the localisation of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway","volume":"109","author":"Reaves","year":"1996","journal-title":"J. Cell Sci."},{"key":"2023072306041408000_bib43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/hmg\/ddi003","article-title":"The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B","volume":"14","author":"Reid","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"2023072306041408000_bib44","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1091\/mbc.E09-10-0879","article-title":"SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis","volume":"21","author":"Renvois\u00e9","year":"2010","journal-title":"Mol. Biol. Cell."},{"key":"2023072306041408000_bib45","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1111\/j.1471-4159.2009.05875.x","article-title":"Pleiotropic effects of spastin on neurite growth depending on expression levels","volume":"108","author":"Riano","year":"2009","journal-title":"J. Neurochem."},{"key":"2023072306041408000_bib46","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nature06482","article-title":"Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin","volume":"451","author":"Roll-Mecak","year":"2008","journal-title":"Nature."},{"key":"2023072306041408000_bib47","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/hmg\/ddi447","article-title":"Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners","volume":"15","author":"Sanderson","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"2023072306041408000_bib48","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1083\/jcb.200312034","article-title":"Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer","volume":"165","author":"Seaman","year":"2004","journal-title":"J. Cell Biol."},{"key":"2023072306041408000_bib49","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/j.1600-0854.2007.00584.x","article-title":"Structure\/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain","volume":"8","author":"Shim","year":"2007","journal-title":"Traffic."},{"key":"2023072306041408000_bib50","doi-asserted-by":"publisher","first-page":"4226","DOI":"10.1091\/mbc.E12-03-0210","article-title":"BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures","volume":"23","author":"Splinter","year":"2012","journal-title":"Mol. Biol. Cell."},{"key":"2023072306041408000_bib51","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nature06172","article-title":"ESCRT-III recognition by VPS4 ATPases","volume":"449","author":"Stuchell-Brereton","year":"2007","journal-title":"Nature."},{"key":"2023072306041408000_bib52","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/ncb2252","article-title":"SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors","volume":"13","author":"Temkin","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"2023072306041408000_bib53","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/ncb1656","article-title":"SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment","volume":"9","author":"Traer","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"2023072306041408000_bib54","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1093\/hmg\/ddp324","article-title":"The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling","volume":"18","author":"Tsang","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"2023072306041408000_bib55","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1600-0854.2011.01297.x","article-title":"SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation","volume":"13","author":"van Weering","year":"2012","journal-title":"Traffic."},{"key":"2023072306041408000_bib56","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nn1841","article-title":"Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules","volume":"10","author":"Wang","year":"2007","journal-title":"Nat. Neurosci."},{"key":"2023072306041408000_bib57","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.devcel.2009.04.016","article-title":"The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network","volume":"17","author":"Wassmer","year":"2009","journal-title":"Dev. Cell."},{"key":"2023072306041408000_bib58","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nature07836","article-title":"Membrane scission by the ESCRT-III complex","volume":"458","author":"Wollert","year":"2009","journal-title":"Nature."},{"key":"2023072306041408000_bib59","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1093\/hmg\/ddl212","article-title":"The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo","volume":"15","author":"Wood","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"2023072306041408000_bib60","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1038\/nsmb.1512","article-title":"Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B","volume":"15","author":"Yang","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2023072306041408000_bib61","doi-asserted-by":"publisher","first-page":"19140","DOI":"10.1073\/pnas.0603788103","article-title":"Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding","volume":"103","author":"Zamborlini","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/202\/3\/527\/1580783\/jcb_201211045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/202\/3\/527\/1580783\/jcb_201211045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T06:05:50Z","timestamp":1690092350000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/202\/3\/527\/37402\/An-ESCRT-spastin-interaction-promotes-fission-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,29]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,8,5]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201211045","relation":{},"ISSN":["1540-8140","0021-9525"],"issn-type":[{"value":"1540-8140","type":"electronic"},{"value":"0021-9525","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7,29]]}}}