{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:15:34Z","timestamp":1791148534895,"version":"4.1.0"},"reference-count":37,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,4,15]]},"abstract":"<jats:p>Postnatal maturation of esophageal musculature involves proximal-to-distal replacement of smooth muscle with skeletal muscle by elusive mechanisms. We report that this process is impaired in mice lacking the cell surface receptor Cdo and identify the underlying developmental mechanism. A myogenic transition zone containing proliferative skeletal muscle precursor cells migrated in a proximal\u2013distal direction, leaving differentiated myofibers in its wake. Distal to the transition zone, smooth muscle fascicles underwent a morphogenetic process whereby they changed their orientation relative to each other and to the lumen. Consequently, a path was cleared for the transition zone, and smooth muscle ultimately occupied only the distal-most esophagus; there was no loss of smooth muscle. Cdo\u2212\/\u2212 mice were specifically defective in fascicular reorientation, resulting in an aberrantly proximal skeletal\u2013smooth muscle boundary. Furthermore, Cdo\u2212\/\u2212 mice displayed megaesophagus and achalasia, and their lower esophageal sphincter was resistant to nitric oxide\u2013induced relaxation, suggesting a developmental linkage between patterning and sphincter function. Collectively, these results illuminate mechanisms of esophageal morphogenesis and motility disorders.<\/jats:p>","DOI":"10.1083\/jcb.201301005","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T21:49:15Z","timestamp":1365457755000},"page":"309-323","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Smooth muscle fascicular reorientation is required for esophageal morphogenesis and dependent on Cdo"],"prefix":"10.1083","volume":"201","author":[{"given":"Anthony I.","family":"Romer","sequence":"first","affiliation":[{"name":"Department of Developmental and Regenerative Biology 1 , and 2"},{"name":"Graduate School of Biomedical Sciences, Mount Sinai School of Medicine, New York, NY 10029 1 , and 2"},{"name":"Department of Developmental and Regenerative Biology 1 , and 2"},{"name":"Graduate School of Biomedical Sciences, Mount Sinai School of Medicine, New York, NY 10029 1 , and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagmohan","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Rattan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department of Developmental and Regenerative Biology 1 , and 2"},{"name":"Graduate School of Biomedical Sciences, Mount Sinai School of Medicine, New York, NY 10029 1 , and 2"},{"name":"Department of Developmental and Regenerative Biology 1 , and 2"},{"name":"Graduate School of Biomedical Sciences, Mount Sinai School of Medicine, New York, NY 10029 1 , and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2013,4,8]]},"reference":[{"key":"2023072307185155300_bib1","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.1242\/dev.00115","article-title":"Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway","volume":"129","author":"Bai","year":"2002","journal-title":"Development."},{"key":"2023072307185155300_bib2","first-page":"G7","article-title":"Release of nitric oxide by activation of nonadrenergic noncholinergic neurons of internal anal sphincter","volume":"264","author":"Chakder","year":"1993","journal-title":"Am. 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