{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:08:59Z","timestamp":1790698139468,"version":"4.1.0"},"reference-count":35,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,11,25]]},"abstract":"<jats:p>Dysbindin is an established schizophrenia susceptibility gene thoroughly studied in the context of the brain. We have previously shown through a yeast two-hybrid screen that it is also a cardiac binding partner of the intercalated disc protein Myozap. Because Dysbindin is highly expressed in the heart, we aimed here at deciphering its cardiac function. Using a serum response factor (SRF) response element reporter-driven luciferase assay, we identified a robust activation of SRF signaling by Dysbindin overexpression that was associated with significant up-regulation of SRF gene targets, such as Acta1 and Actc1. Concurrently, we identified RhoA as a novel binding partner of Dysbindin. Further phenotypic and mechanistic characterization revealed that Dysbindin induced cardiac hypertrophy via RhoA\u2013SRF and MEK1\u2013ERK1 signaling pathways. In conclusion, we show a novel cardiac role of Dysbindin in the activation of RhoA\u2013SRF and MEK1\u2013ERK1 signaling pathways and in the induction of cardiac hypertrophy. Future in vivo studies should examine the significance of Dysbindin in cardiomyopathy.<\/jats:p>","DOI":"10.1083\/jcb.201303052","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T08:18:22Z","timestamp":1388737102000},"page":"643-656","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Dysbindin is a potent inducer of RhoA\u2013SRF-mediated cardiomyocyte hypertrophy"],"prefix":"10.1083","volume":"203","author":[{"given":"Ashraf Yusuf","family":"Rangrez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, University Medical Center Schleswig-Holstein, D-24105 Kiel, Germany 1"},{"name":"German Centre for Cardiovascular Research, partner site Hamburg\/Kiel\/L\u00fcbeck, D-24105 Kiel, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bernt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Medical Center Schleswig-Holstein, D-24105 Kiel, Germany 1"},{"name":"German Centre for Cardiovascular Research, partner site Hamburg\/Kiel\/L\u00fcbeck, D-24105 Kiel, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Poyanmehr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Medical Center Schleswig-Holstein, D-24105 Kiel, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violetta","family":"Harazin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Medical Center Schleswig-Holstein, D-24105 Kiel, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inka","family":"Boomgaarden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Medical Center Schleswig-Holstein, D-24105 Kiel, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Medical Center Schleswig-Holstein, D-24105 Kiel, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Rohrbeck","sequence":"additional","affiliation":[{"name":"Institute of Toxicology, Hannover Medical School, D-30625 Hannover, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derk","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Medical Center Schleswig-Holstein, D-24105 Kiel, Germany 1"},{"name":"German Centre for Cardiovascular Research, partner site Hamburg\/Kiel\/L\u00fcbeck, D-24105 Kiel, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Medical Center Schleswig-Holstein, D-24105 Kiel, Germany 1"},{"name":"German Centre for Cardiovascular Research, partner site Hamburg\/Kiel\/L\u00fcbeck, D-24105 Kiel, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2013,11,25]]},"reference":[{"key":"2023072306135138700_bib1","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/ng.171","article-title":"Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database","volume":"40","author":"Allen","year":"2008","journal-title":"Nat. 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