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In agreement with previous studies showing that FHOD1 is activated by the small GTPase Rac1, Rac1 was enriched and activated at the membrane surrounding actin tails. Rac1 depletion or expression of dominant-negative Rac1 phenocopied the effects of FHOD1 depletion and impaired the recruitment of FHOD1 to actin tails. FHOD1 overexpression rescued the actin tail formation defects observed in cells overexpressing dominant-negative Rac1. Altogether, our results indicate that, to display robust actin-based motility, vaccinia virus integrates the activity of the N-WASP\u2013ARP2\/3 and Rac1\u2013FHOD1 pathways.<\/jats:p>","DOI":"10.1083\/jcb.201303055","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T05:29:07Z","timestamp":1380000547000},"page":"1075-1090","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin\u2013based motility"],"prefix":"10.1083","volume":"202","author":[{"given":"Diego E.","family":"Alvarez","sequence":"first","affiliation":[{"name":"Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT, 06519"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Agaisse","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT, 06519"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2013,9,23]]},"reference":[{"key":"2023072306081046300_bib1","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1074\/jbc.M006205200","article-title":"Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain","volume":"276","author":"Alberts","year":"2001","journal-title":"J. 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