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We found that WASH and exocyst are required for matrix degradation by an exocytic mechanism that involves tubular connections between MT1-MMP\u2013positive late endosomes and the plasma membrane in contact with the matrix. This ensures focal delivery of MT1-MMP and supports pericellular matrix degradation and tumor cell invasion into different pathologically relevant matrix environments. Our data suggest a general mechanism used by tumor cells to breach the basement membrane and for invasive migration through fibrous collagen-enriched tissues surrounding the tumor.<\/jats:p>","DOI":"10.1083\/jcb.201306162","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T23:51:19Z","timestamp":1387237879000},"page":"1063-1079","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":207,"title":["Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia"],"prefix":"10.1083","volume":"203","author":[{"given":"Pedro","family":"Monteiro","sequence":"first","affiliation":[{"name":"Research Center, Institut Curie, 75005 Paris, France 1"},{"name":"Membrane and Cytoskeleton Dynamics 2 and 3"},{"name":"Cell and Tissue Imaging Facility, Centre National de la Recherche Scientifique UMR 144, 75005 Paris, France 2 and 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