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Brwd1 deficiency caused down-regulation of \u223c300 mostly spermatid-specific transcripts in testis, including nearly complete elimination of those encoding the protamines and transition proteins, but was not associated with global epigenetic changes in chromatin, which suggests that BRWD1 acts selectively. In females, Brwd1 ablation caused severe chromosome condensation and structural defects associated with abnormal telomere structure but only minor changes in gene expression at the germinal vesicle stage, including more than twofold overexpression of the histone methyltransferase MLL5 and LINE-1 elements transposons. Thus, loss of BRWD1 function interferes with the completion of oogenesis and spermatogenesis through sexually dimorphic mechanisms: it is essential in females for epigenetic control of meiotic chromosome stability and in males for haploid gene transcription during postmeiotic sperm differentiation.<\/jats:p>","DOI":"10.1083\/jcb.201404109","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T08:03:49Z","timestamp":1419926629000},"page":"53-69","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability"],"prefix":"10.1083","volume":"208","author":[{"given":"Shrivatsav","family":"Pattabiraman","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences 1 and 2"},{"name":"Center for Vertebrate Genomics, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853 1 and 2"},{"name":"Department of Biomedical Sciences 1 and 2"},{"name":"Center for Vertebrate Genomics, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA 30602 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Guisado","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences 1 and 2"},{"name":"Center for Vertebrate Genomics, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853 1 and 2"},{"name":"Department of Biomedical Sciences 1 and 2"},{"name":"Center for Vertebrate Genomics, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Eppig","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, ME 04609 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Schimenti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences 1 and 2"},{"name":"Center for Vertebrate Genomics, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853 1 and 2"},{"name":"Department of Biomedical Sciences 1 and 2"},{"name":"Center for Vertebrate Genomics, Cornell University, College of Veterinary Medicine, Ithaca, NY 14853 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabindranath","family":"De La Fuente","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Georgia College of Veterinary Medicine, Athens, GA 30602 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"2023072307052509000_bib1","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1262\/jrd.10-068A","article-title":"Global gene silencing is caused by the dissociation of RNA polymerase II from DNA in mouse oocytes","volume":"56","author":"Abe","year":"2010","journal-title":"J. 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