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In this review, we propose that as a result of the tight cell biological interconnection of axons and myelin, damage to either can spread, which might convert a local inflammatory disease process early in MS into the global progressive disorder seen during later stages. This mode of spreading could also apply to other neurological disorders.<\/jats:p>","DOI":"10.1083\/jcb.201404154","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T16:26:06Z","timestamp":1407169566000},"page":"335-345","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":80,"title":["A unified cell biological perspective on axon\u2013myelin injury"],"prefix":"10.1083","volume":"206","author":[{"given":"Mikael","family":"Simons","sequence":"first","affiliation":[{"name":"Cellular Neuroscience, Max Planck Institute of Experimental Medicine, 37075 G\u00f6ttingen, Germany 1"},{"name":"Department of Neurology, University of G\u00f6ttingen, 37075 G\u00f6ttingen, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Misgeld","sequence":"additional","affiliation":[{"name":"Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany 3"},{"name":"German Center for Neurodegenerative Diseases, 80336 Munich, Germany 4"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kerschensteiner","sequence":"additional","affiliation":[{"name":"Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany 5"},{"name":"Institute of Clinical Neuroimmunology, Ludwig Maximilian University Munich, 81377 Munich, Germany 6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"2023072307522368700_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/jnen\/62.1.25","article-title":"Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases","volume":"62","author":"Aboul-Enein","year":"2003","journal-title":"J. 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