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The targeting of lysosomal and granular enzymes lacking M6P residues is less affected in dendritic cells and T cells and sufficient for maintenance of degradative and lytic functions. M6P deficiency also impairs serum immunoglobulin levels and antibody responses to vaccination in patients. Our data demonstrate the critical role of M6P-dependent transport routes for B cell functions in vivo and humoral immunity in mice and human.<\/jats:p>","DOI":"10.1083\/jcb.201407077","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T15:23:06Z","timestamp":1421680986000},"page":"171-180","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions"],"prefix":"10.1083","volume":"208","author":[{"given":"Takanobu","family":"Otomo","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Children\u2019s Hospital 1 ; 3 ; and 4"},{"name":"Department of Electron Microscopy, Center for Molecular Neurobiology 1 ; 3 ; and 4"},{"name":"Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 1 ; 3 ; and 4"},{"name":"Department of Pediatrics, Osaka University Graduate School of Medicine, 5650871 Suita, Osaka, Japan 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Schweizer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Children\u2019s Hospital 1 ; 3 ; and 4"},{"name":"Department of Electron Microscopy, Center for Molecular Neurobiology 1 ; 3 ; and 4"},{"name":"Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 1 ; 3 ; and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Kollmann","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Children\u2019s Hospital 1 ; 3 ; and 4"},{"name":"Department of Electron Microscopy, Center for Molecular Neurobiology 1 ; 3 ; and 4"},{"name":"Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 1 ; 3 ; and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9a","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Children\u2019s Hospital 1 ; 3 ; and 4"},{"name":"Department of Electron Microscopy, Center for Molecular Neurobiology 1 ; 3 ; and 4"},{"name":"Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 1 ; 3 ; and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Muschol","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Children\u2019s Hospital 1 ; 3 ; and 4"},{"name":"Department of Electron Microscopy, Center for Molecular Neurobiology 1 ; 3 ; and 4"},{"name":"Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 1 ; 3 ; and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Tolosa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Children\u2019s Hospital 1 ; 3 ; and 4"},{"name":"Department of Electron Microscopy, Center for Molecular Neurobiology 1 ; 3 ; and 4"},{"name":"Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 1 ; 3 ; and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Willi","family":"Mittr\u00fccker","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Children\u2019s Hospital 1 ; 3 ; and 4"},{"name":"Department of Electron Microscopy, Center for Molecular Neurobiology 1 ; 3 ; and 4"},{"name":"Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 1 ; 3 ; and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Braulke","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Children\u2019s Hospital 1 ; 3 ; and 4"},{"name":"Department of Electron Microscopy, Center for Molecular Neurobiology 1 ; 3 ; and 4"},{"name":"Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 1 ; 3 ; and 4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2015,1,19]]},"reference":[{"key":"2023072307085665500_bib1","doi-asserted-by":"publisher","first-page":"31446","DOI":"10.1074\/jbc.271.49.31446","article-title":"Bovine UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase. 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