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Sall4 is rapidly mobilized to the sites of DSBs after DNA damage. Furthermore, Sall4 interacts with Rad50 and stabilizes the Mre11\u2013Rad50\u2013Nbs1 complex for the efficient recruitment and activation of ATM. Sall4 also interacts with Baf60a, a member of the SWI\/SNF (switch\/sucrose nonfermentable) ATP-dependent chromatin-remodeling complex, which is responsible for recruiting Sall4 to the site of DNA DSB damage. Our findings provide novel mechanisms to coordinate stemness of ESCs with DNA damage response, ensuring genomic stability during the expansion of ESCs.<\/jats:p>","DOI":"10.1083\/jcb.201408106","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T19:02:16Z","timestamp":1425322936000},"page":"513-520","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Stemness factor Sall4 is required for DNA damage response in embryonic stem cells"],"prefix":"10.1083","volume":"208","author":[{"given":"Jianhua","family":"Xiong","sequence":"first","affiliation":[{"name":"Section of Molecular Biology 1 and 2"},{"name":"Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilyana","family":"Todorova","sequence":"additional","affiliation":[{"name":"Section of Molecular Biology 1 and 2"},{"name":"Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning-Yuan","family":"Su","sequence":"additional","affiliation":[{"name":"Section of Molecular Biology 1 and 2"},{"name":"Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchul","family":"Kim","sequence":"additional","affiliation":[{"name":"Section of Molecular Biology 1 and 2"},{"name":"Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 1 and 2"},{"name":"Cancer Research Institute, Southern Medical University, Guangzhou 510515, Guangdong, China 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Section of Molecular Biology 1 and 2"},{"name":"Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouxin","family":"Shen","sequence":"additional","affiliation":[{"name":"Section of Molecular Biology 1 and 2"},{"name":"Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Briggs","sequence":"additional","affiliation":[{"name":"Section of Molecular Biology 1 and 2"},{"name":"Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Section of Molecular Biology 1 and 2"},{"name":"Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2015,3,2]]},"reference":[{"key":"2023072308212198700_bib1","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.cell.2012.08.023","article-title":"Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase","volume":"150","author":"Buganim","year":"2012","journal-title":"Cell."},{"key":"2023072308212198700_bib2","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1021\/jm800885d","article-title":"A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4\u2032-chlorophenyl)thiazol-2-yl)hydrazone","volume":"52","author":"Chimenti","year":"2009","journal-title":"J. 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