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SDF-1\u2013induced cell migration and activation of extracellular signal-regulated kinases 1 and 2 (ERK) MAPK were strongly inhibited, even when forced overexpression restored CXCR4 levels. Similar results were seen in KMBC and HEK293 cells. Exploring the mechanism, we found that SDF-1 treatment induced IQGAP1 binding to \u03b1-tubulin and localization to CXCR4-containing endosomes and that CXCR4-containing EEA-1+ endosomes were abnormally located distal from the microtubule (MT)-organizing center (MTOC) in IQGAP1-deficient cells. Thus, IQGAP1 critically mediates CXCR4 cell surface expression and signaling, evidently by regulating EEA-1+ endosome interactions with MTs during CXCR4 trafficking and recycling. IQGAP1 may similarly promote CXCR4 functions in other cancer cell types.<\/jats:p>","DOI":"10.1083\/jcb.201411045","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T15:29:36Z","timestamp":1437406176000},"page":"257-272","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes"],"prefix":"10.1083","volume":"210","author":[{"given":"Adebowale O.","family":"Bamidele","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905 1"},{"name":"Department of Immunology, Mayo Clinic, Rochester, MN 55905 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly N.","family":"Kremer","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, MN 55905 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hirsova","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C.","family":"Clift","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, MN 55905 2"},{"name":"Neurobiology of Disease Research Program, Mayo Clinic, Rochester, MN 55905 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Gores","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Billadeau","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, MN 55905 2"},{"name":"Division of Oncology Research, Mayo Clinic, Rochester, MN 55905 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Hedin","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic, Rochester, MN 55905 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"key":"2023072307544470000_bib1","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1091\/mbc.E12-02-0133","article-title":"G\u03b1s promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin)","volume":"23","author":"Beas","year":"2012","journal-title":"Mol. 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