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Efficient ciliogenesis in chicken DT40 B lymphocytes required centrin2. We disrupted CETN2 in human retinal pigmented epithelial cells, and despite having intact centrioles, they were unable to make cilia upon serum starvation, showing abnormal localization of distal appendage proteins and failing to remove the ciliation inhibitor CP110. Knockdown of CP110 rescued ciliation in CETN2-deficient cells. Thus, centrin2 regulates primary ciliogenesis through controlling CP110 levels.<\/jats:p>","DOI":"10.1083\/jcb.201411070","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T21:52:56Z","timestamp":1425937976000},"page":"693-701","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":76,"title":["Centrin2 regulates CP110 removal in primary cilium formation"],"prefix":"10.1083","volume":"208","author":[{"given":"Suzanna L.","family":"Prosser","sequence":"first","affiliation":[{"name":"Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran G.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"key":"2023072308231298700_bib1","doi-asserted-by":"publisher","first-page":"E2841","DOI":"10.1073\/pnas.1401777111","article-title":"Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole","volume":"111","author":"\u010caj\u00e1nek","year":"2014","journal-title":"Proc. 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