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We used in vivo time-lapse quantitative microscopy to show that clathrin, dynamin, and the ADP-ribosylation factor 6, three components of the endocytic machinery, accumulate around wounds in Drosophila melanogaster embryos in a process that requires calcium signaling and actomyosin contractility. Blocking endocytosis with pharmacological or genetic approaches disrupted wound repair. The defect in wound closure was accompanied by impaired removal of E-cadherin from the wound edge and defective actomyosin cable assembly. E-cadherin overexpression also resulted in reduced actin accumulation around wounds and slower wound closure. Reducing E-cadherin levels in embryos in which endocytosis was blocked rescued actin localization to the wound margin. Our results demonstrate a central role for endocytosis in wound healing and indicate that polarized E-cadherin endocytosis is necessary for actomyosin remodeling during embryonic wound repair.<\/jats:p>","DOI":"10.1083\/jcb.201501076","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T21:10:42Z","timestamp":1440450642000},"page":"801-816","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":87,"title":["Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair"],"prefix":"10.1083","volume":"210","author":[{"given":"Miranda V.","family":"Hunter","sequence":"first","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghoon M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony J.C.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Fernandez-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada 1"},{"name":"Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada 2"},{"name":"Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"2023072308081661700_bib1","doi-asserted-by":"publisher","first-page":"5984","DOI":"10.1242\/jcs.109066","article-title":"Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string","volume":"125","author":"Abreu-Blanco","year":"2012","journal-title":"J. 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