{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:23:50Z","timestamp":1790162630965,"version":"4.1.0"},"reference-count":66,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,12,21]]},"abstract":"<jats:p>Cells rapidly repair plasma membrane (PM) damage by a process requiring Ca2+-dependent lysosome exocytosis. Acid sphingomyelinase (ASM) released from lysosomes induces endocytosis of injured membrane through caveolae, membrane invaginations from lipid rafts. How B lymphocytes, lacking any known form of caveolin, repair membrane injury is unknown. Here we show that B lymphocytes repair PM wounds in a Ca2+-dependent manner. Wounding induces lysosome exocytosis and endocytosis of dextran and the raft-binding cholera toxin subunit B (CTB). Resealing is reduced by ASM inhibitors and ASM deficiency and enhanced or restored by extracellular exposure to sphingomyelinase. B cell activation via B cell receptors (BCRs), a process requiring lipid rafts, interferes with PM repair. Conversely, wounding inhibits BCR signaling and internalization by disrupting BCR\u2013lipid raft coclustering and by inducing the endocytosis of raft-bound CTB separately from BCR into tubular invaginations. Thus, PM repair and B cell activation interfere with one another because of competition for lipid rafts, revealing how frequent membrane injury and repair can impair B lymphocyte\u2013mediated immune responses.<\/jats:p>","DOI":"10.1083\/jcb.201505030","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T23:08:11Z","timestamp":1455836891000},"page":"1193-1205","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Lipid raft\u2013dependent plasma membrane repair interferes with the activation of B lymphocytes"],"prefix":"10.1083","volume":"211","author":[{"given":"Heather","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Castro-Gomes","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Corrotte","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy K.","family":"Maugel","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma W.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"2023072308123873600_bib1","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.tcb.2014.07.008","article-title":"Damage control: cellular mechanisms of plasma membrane repair","volume":"24","author":"Andrews","year":"2014","journal-title":"Trends Cell Biol."},{"key":"2023072308123873600_bib2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nature01573","article-title":"Defective membrane repair in dysferlin-deficient muscular dystrophy","volume":"423","author":"Bansal","year":"2003","journal-title":"Nature."},{"key":"2023072308123873600_bib3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nri2454","article-title":"The who, how and where of antigen presentation to B cells","volume":"9","author":"Batista","year":"2009","journal-title":"Nat. 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