{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:53:44Z","timestamp":1791348824307,"version":"4.3.1"},"reference-count":55,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10,26]]},"abstract":"<jats:p>Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered membrane type 1\u2013matrix metalloproteinase (MT1-MMP) as the key protease for collagen breakdown. Understanding how MT1-MMP is delivered to the surface of tumor cells is essential for cancer cell biology. In this study, we identify ARF6 together with c-Jun NH2-terminal kinase\u2013interacting protein 3 and 4 (JIP3 and JIP4) effectors as critical regulators of this process. Silencing ARF6 or JIP3\/JIP4 in breast tumor cells results in MT1-MMP endosome mispositioning and reduces MT1-MMP exocytosis and tumor cell invasion. JIPs are recruited by Wiskott-Aldrich syndrome protein and scar homologue (WASH) on MT1-MMP endosomes on which they recruit dynein\u2013dynactin and kinesin-1. The interaction of plasma membrane ARF6 with endosomal JIPs coordinates dynactin\u2013dynein and kinesin-1 activity in a tug-of-war mechanism, leading to MT1-MMP endosome tubulation and exocytosis. In addition, we find that ARF6, MT1-MMP, and kinesin-1 are up-regulated in high-grade triple-negative breast cancers. These data identify a critical ARF6\u2013JIP\u2013MT1-MMP\u2013dynein\u2013dynactin\u2013kinesin-1 axis promoting an invasive phenotype of breast cancer cells.<\/jats:p>","DOI":"10.1083\/jcb.201506002","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T13:27:54Z","timestamp":1445866074000},"page":"339-358","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":160,"title":["ARF6\u2013JIP3\/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion"],"prefix":"10.1083","volume":"211","author":[{"given":"Valentina","family":"Marchesin","sequence":"first","affiliation":[{"name":"PSL Research University, Institut Curie, 75248 Paris, France 1"},{"name":"Membrane and Cytoskeleton Dynamics, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 144, 75248 Paris, France 6"},{"name":"University Pierre et Marie Curie Paris 06, 75000 Paris, France 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