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Melanosomes and other lysosome-related organelles obtain cargoes from early endosomes, but the fusion machinery involved and its recycling pathway are unknown. Here, we show that the v-SNARE VAMP7 mediates fusion of melanosomes with tubular transport carriers that also carry the cargo protein TYRP1 and that require BLOC-1 for their formation. Using live-cell imaging, we identify a pathway for VAMP7 recycling from melanosomes that employs distinct tubular carriers. The recycling carriers also harbor the VAMP7-binding scaffold protein VARP and the tissue-restricted Rab GTPase RAB38. Recycling carrier formation is dependent on the RAB38 exchange factor BLOC-3. Our data suggest that VAMP7 mediates fusion of BLOC-1\u2013dependent transport carriers with melanosomes, illuminate SNARE recycling from melanosomes as a critical BLOC-3\u2013dependent step, and likely explain the distinct hypopigmentation phenotypes associated with BLOC-1 and BLOC-3 deficiency in Hermansky\u2013Pudlak syndrome variants.<\/jats:p>","DOI":"10.1083\/jcb.201605090","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T13:53:01Z","timestamp":1470059581000},"page":"293-308","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":103,"title":["BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers"],"prefix":"10.1083","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8986-5021","authenticated-orcid":false,"given":"Megan K.","family":"Dennis","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104 1"},{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 2"},{"name":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Delevoye","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Centre National de la Recherche Scientifique, UMR144, 75005 Paris, France 4"},{"name":"Structure and Membrane Compartments, Institut Curie, 75005 Paris, France 5"},{"name":"Cell and Tissue Imaging Facility (PICT-IBiSA), 75005 Paris, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-4128","authenticated-orcid":false,"given":"Amanda","family":"Acosta-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104 1"},{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 2"},{"name":"Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-7773","authenticated-orcid":false,"given":"Ilse","family":"Hurbain","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Centre National de la Recherche Scientifique, UMR144, 75005 Paris, France 4"},{"name":"Structure and Membrane Compartments, Institut Curie, 75005 Paris, France 5"},{"name":"Cell and Tissue Imaging Facility (PICT-IBiSA), 75005 Paris, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Romao","sequence":"additional","affiliation":[{"name":"Institut Curie, PSL Research University, Centre National de la Recherche Scientifique, UMR144, 75005 Paris, France 4"},{"name":"Structure and Membrane Compartments, Institut Curie, 75005 Paris, France 5"},{"name":"Cell and Tissue Imaging Facility (PICT-IBiSA), 75005 Paris, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5570-7615","authenticated-orcid":false,"given":"Geoffrey G.","family":"Hesketh","sequence":"additional","affiliation":[{"name":"Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, England, UK 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-5527","authenticated-orcid":false,"given":"Philip S.","family":"Goff","sequence":"additional","affiliation":[{"name":"Cell Biology and Genetics Research Centre, St. George\u2019s, University of London, London SW17 0RE, England, UK 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4177-8236","authenticated-orcid":false,"given":"Elena V.","family":"Sviderskaya","sequence":"additional","affiliation":[{"name":"Cell Biology and Genetics Research Centre, St. George\u2019s, University of London, London SW17 0RE, England, UK 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3639-7527","authenticated-orcid":false,"given":"Dorothy C.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Cell Biology and Genetics Research Centre, St. George\u2019s, University of London, London SW17 0RE, England, UK 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-9760","authenticated-orcid":false,"given":"J. 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