{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:23:41Z","timestamp":1791318221651,"version":"4.3.1"},"reference-count":108,"publisher":"Rockefeller University Press","issue":"5","funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["100993\/Z\/13\/Z"],"award-info":[{"award-number":["100993\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FRM-DEQ20100318279"],"award-info":[{"award-number":["FRM-DEQ20100318279"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008656","name":"Fondation Innovations en Infectiologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008656","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,8,29]]},"abstract":"<jats:p>The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and Toxoplasma, achieve remarkable speeds of directional cell movement. This rapidity is achieved via a divergent actomyosin motor system, housed within a narrow compartment that lies underneath the length of the parasite plasma membrane. How this motor functions at a mechanistic level during motility and host cell invasion is a matter of debate. Here, we integrate old and new insights toward refining the current model for the function of this motor with the aim of revitalizing interest in the mechanics of how these deadly pathogens move.<\/jats:p>","DOI":"10.1083\/jcb.201605100","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T09:18:16Z","timestamp":1472462296000},"page":"507-515","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Reassessing the mechanics of parasite motility and host-cell invasion"],"prefix":"10.1083","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-7463","authenticated-orcid":false,"given":"Isabelle","family":"Tardieux","sequence":"first","affiliation":[{"name":"Institute of Advanced BioSciences, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1209, Centre National de la Recherche Scientifique UMR 5309, Universit\u00e9 Grenoble Alpes, 38000, Grenoble, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-352X","authenticated-orcid":false,"given":"Jake","family":"Baum","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Imperial College London, London SW7 2AZ, England, UK 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2016,8,29]]},"reference":[{"key":"2023072310112206400_bib1","first-page":"285","article-title":"Transmission and scanning electron microscopy of host cell entry by Toxoplasma gondii","volume":"87","author":"Aikawa","year":"1977","journal-title":"Am. J. Pathol."},{"key":"2023072310112206400_bib2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1083\/jcb.77.1.72","article-title":"Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite","volume":"77","author":"Aikawa","year":"1978","journal-title":"J. Cell Biol."},{"key":"2023072310112206400_bib3","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1371\/journal.ppat.0010017","article-title":"Identification of the moving junction complex of Toxoplasma gondii: A collaboration between distinct secretory organelles","volume":"1","author":"Alexander","year":"2005","journal-title":"PLoS Pathog."},{"key":"2023072310112206400_bib4","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nm1350","article-title":"Quantitative imaging of Plasmodium transmission from mosquito to mammal","volume":"12","author":"Amino","year":"2006","journal-title":"Nat. Med."},{"key":"2023072310112206400_bib5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nmeth.2301","article-title":"Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms","volume":"10","author":"Andenmatten","year":"2013","journal-title":"Nat. Methods."},{"key":"2023072310112206400_bib6","doi-asserted-by":"publisher","first-page":"e32188","DOI":"10.1371\/journal.pone.0032188","article-title":"Spatial localisation of actin filaments across developmental stages of the malaria parasite","volume":"7","author":"Angrisano","year":"2012","journal-title":"PLoS One."},{"key":"2023072310112206400_bib7","doi-asserted-by":"publisher","first-page":"e35227","DOI":"10.1371\/journal.pone.0035227","article-title":"Gliding motility of Babesia bovis merozoites visualized by time-lapse video microscopy","volume":"7","author":"Asada","year":"2012","journal-title":"PLoS One."},{"key":"2023072310112206400_bib8","doi-asserted-by":"publisher","first-page":"e1005710","DOI":"10.1371\/journal.ppat.1005710","article-title":"The actin filament-binding protein coronin regulates motility in Plasmodium sporozoites","volume":"12","author":"Bane","year":"2016","journal-title":"PLoS Pathog."},{"key":"2023072310112206400_bib9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1017\/S0031182000047247","article-title":"Structure and invasive behaviour of Plasmodium knowlesi merozoites in vitro","volume":"71","author":"Bannister","year":"1975","journal-title":"Parasitology."},{"key":"2023072310112206400_bib10","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1038\/ncomms3552","article-title":"Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion","volume":"4","author":"Bargieri","year":"2013","journal-title":"Nat. Commun."},{"key":"2023072310112206400_bib11","doi-asserted-by":"publisher","first-page":"e1004273","DOI":"10.1371\/journal.ppat.1004273","article-title":"Host cell invasion by apicomplexan parasites: The junction conundrum","volume":"10","author":"Bargieri","year":"2014","journal-title":"PLoS Pathog."},{"key":"2023072310112206400_bib12","doi-asserted-by":"publisher","first-page":"042720","DOI":"10.1103\/PhysRevE.90.042720","article-title":"Geometrical model for malaria parasite migration in structured environments","volume":"90","author":"Battista","year":"2014","journal-title":"Phys. Rev. E Stat. Nonlin. Soft Matter Phys."},{"key":"2023072310112206400_bib13","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1126\/science.1209875","article-title":"Biochemistry. Revealing a parasite\u2019s invasive trick","volume":"333","author":"Baum","year":"2011","journal-title":"Science."},{"key":"2023072310112206400_bib14","doi-asserted-by":"publisher","first-page":"5197","DOI":"10.1074\/jbc.M509807200","article-title":"A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites","volume":"281","author":"Baum","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2023072310112206400_bib15","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1186\/s12915-014-0108-y","article-title":"The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force","volume":"12","author":"Bichet","year":"2014","journal-title":"BMC Biol."},{"key":"2023072310112206400_bib16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrmicro1800","article-title":"Kiss and spit: The dual roles of Toxoplasma rhoptries","volume":"6","author":"Boothroyd","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"2023072310112206400_bib17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jsb.2015.02.008","article-title":"The apicomplexan glideosome and adhesins - Structures and function","volume":"190","author":"Boucher","year":"2015","journal-title":"J. Struct. Biol."},{"key":"2023072310112206400_bib18","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.mib.2007.09.013","article-title":"Rhoptries: An arsenal of secreted virulence factors","volume":"10","author":"Bradley","year":"2007","journal-title":"Curr. Opin. Microbiol."},{"key":"2023072310112206400_bib19","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0166-6851(00)00280-2","article-title":"Induction of secretion and surface capping of microneme proteins in Eimeria tenella","volume":"110","author":"Bumstead","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"2023072310112206400_bib20","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.1091\/mbc.E03-06-0355","article-title":"Sites of interaction between aldolase and thrombospondin-related anonymous protein in plasmodium","volume":"14","author":"Buscaglia","year":"2003","journal-title":"Mol. Biol. Cell."},{"key":"2023072310112206400_bib21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/978-0-387-78267-6_2","article-title":"Microneme proteins in apicomplexans","volume":"47","author":"Carruthers","year":"2008","journal-title":"Subcell. Biochem."},{"key":"2023072310112206400_bib22","doi-asserted-by":"publisher","first-page":"1257998","DOI":"10.1126\/science.1257998","article-title":"Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution","volume":"346","author":"Chen","year":"2014","journal-title":"Science."},{"key":"2023072310112206400_bib23","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ceb.2016.03.007","article-title":"Role of the ER and Golgi in protein export by Apicomplexa","volume":"41","author":"Coffey","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072310112206400_bib24","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.pt.2013.03.003","article-title":"Plasmodium rhoptry proteins: Why order is important","volume":"29","author":"Counihan","year":"2013","journal-title":"Trends Parasitol."},{"key":"2023072310112206400_bib25","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1083\/jcb.201206112","article-title":"The cellular and molecular basis for malaria parasite invasion of the human red blood cell","volume":"198","author":"Cowman","year":"2012","journal-title":"J. Cell Biol."},{"key":"2023072310112206400_bib26","first-page":"4","article-title":"The progressive movement of gregarines","volume":"54","author":"Crawley","year":"1902","journal-title":"Proc Natl Acad Sci Philadelphia."},{"key":"2023072310112206400_bib27","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.bpj.2014.07.010","article-title":"Quantitation of malaria parasite-erythrocyte cell-cell interactions using optical tweezers","volume":"107","author":"Crick","year":"2014","journal-title":"Biophys. J."},{"key":"2023072310112206400_bib28","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/cmi.12498","article-title":"The aspartyl protease TgASP5 mediates the export of the Toxoplasma GRA16 and GRA24 effectors into host cells","volume":"18","author":"Curt-Varesano","year":"2016","journal-title":"Cell. Microbiol."},{"key":"2023072310112206400_bib29","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1084\/jem.20062405","article-title":"Cryoelectron tomography reveals periodic material at the inner side of subpellicular microtubules in apicomplexan parasites","volume":"204","author":"Cyrklaff","year":"2007","journal-title":"J. Exp. Med."},{"key":"2023072310112206400_bib30","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.mib.2009.06.008","article-title":"Mechanisms controlling glideosome function in apicomplexans","volume":"12","author":"Daher","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"2023072310112206400_bib31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.bpj.2014.05.024","article-title":"Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte","volume":"107","author":"Dasgupta","year":"2014","journal-title":"Biophys. J."},{"key":"2023072310112206400_bib32","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1126\/science.1162912","article-title":"Stretching single talin rod molecules activates vinculin binding","volume":"323","author":"del Rio","year":"2009","journal-title":"Science."},{"key":"2023072310112206400_bib33","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0092-8674(00)81071-5","article-title":"Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite","volume":"84","author":"Dobrowolski","year":"1996","journal-title":"Cell."},{"key":"2023072310112206400_bib34","doi-asserted-by":"publisher","first-page":"e00557","DOI":"10.1128\/mBio.00557-15","article-title":"Toxoplasma actin is required for efficient host cell invasion","volume":"6","author":"Drewry","year":"2015","journal-title":"MBio."},{"key":"2023072310112206400_bib35","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1126\/science.803712","article-title":"Invasion of erythrocytes by malaria merozoites","volume":"187","author":"Dvorak","year":"1975","journal-title":"Science."},{"key":"2023072310112206400_bib36","doi-asserted-by":"publisher","first-page":"e91819","DOI":"10.1371\/journal.pone.0091819","article-title":"The toxoplasma Acto-MyoA motor complex is important but not essential for gliding motility and host cell invasion","volume":"9","author":"Egarter","year":"2014","journal-title":"PLoS One"},{"key":"2023072310112206400_bib37","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/368113a0","article-title":"Single myosin molecule mechanics: Piconewton forces and nanometre steps","volume":"368","author":"Finer","year":"1994","journal-title":"Nature."},{"key":"2023072310112206400_bib38","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.chom.2010.09.002","article-title":"Functional dissection of the apicomplexan glideosome molecular architecture","volume":"8","author":"Fr\u00e9nal","year":"2010","journal-title":"Cell Host Microbe."},{"key":"2023072310112206400_bib39","first-page":"201","article-title":"Shape, movement in situ and locomotion of plasmodial ookinetes","volume":"23","author":"Freyvogel","year":"1966","journal-title":"Acta Trop."},{"key":"2023072310112206400_bib40","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/(SICI)1097-0169(1996)34:2&lt;152::AID-CM6&gt;3.0.CO;2-D","article-title":"Kinematic analysis of Toxoplasma gondii motility","volume":"34","author":"Frixione","year":"1996","journal-title":"Cell Motil. Cytoskeleton."},{"key":"2023072310112206400_bib41","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1083\/jcb.200311137","article-title":"Identification of the membrane receptor of a class XIV myosin in Toxoplasma gondii","volume":"165","author":"Gaskins","year":"2004","journal-title":"J. Cell Biol."},{"key":"2023072310112206400_bib42","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.chom.2009.01.011","article-title":"Host cell entry by apicomplexa parasites requires actin polymerization in the host cell","volume":"5","author":"Gonzalez","year":"2009","journal-title":"Cell Host Microbe."},{"key":"2023072310112206400_bib43","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1093\/molbev\/msq321","article-title":"Ciliate pellicular proteome identifies novel protein families with characteristic repeat motifs that are common to alveolates","volume":"28","author":"Gould","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"2023072310112206400_bib44","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.ijpara.2012.09.009","article-title":"Evolution of apicomplexan secretory organelles","volume":"42","author":"Gubbels","year":"2012","journal-title":"Int. J. Parasitol."},{"key":"2023072310112206400_bib45","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1091\/mbc.10.11.3539","article-title":"Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion","volume":"10","author":"H\u00e5kansson","year":"1999","journal-title":"Mol. Biol. Cell."},{"key":"2023072310112206400_bib46","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1111\/cmi.12132","article-title":"Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion","volume":"15","author":"Hanssen","year":"2013","journal-title":"Cell. Microbiol."},{"key":"2023072310112206400_bib47","doi-asserted-by":"publisher","first-page":"e01111","DOI":"10.1128\/mBio.01111-13","article-title":"Shear forces enhance Toxoplasma gondii tachyzoite motility on vascular endothelium","volume":"5","author":"Harker","year":"2014","journal-title":"MBio."},{"key":"2023072310112206400_bib48","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.semcdb.2015.09.020","article-title":"Gliding motility in apicomplexan parasites","volume":"46","author":"Heintzelman","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"2023072310112206400_bib49","first-page":"81","article-title":"A cinematographic study of the penetration of cultured cells by Toxoplasma gondii","volume":"14","author":"Hirai","year":"1966","journal-title":"Jpn. J. Vet. Res."},{"key":"2023072310112206400_bib50","doi-asserted-by":"publisher","first-page":"4","DOI":"10.7554\/eLife.07789","article-title":"Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition","volume":"4","author":"Hopp","year":"2015","journal-title":"eLife."},{"key":"2023072310112206400_bib51","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S1097-2765(03)00113-8","article-title":"Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites","volume":"11","author":"Jewett","year":"2003","journal-title":"Mol. Cell."},{"key":"2023072310112206400_bib52","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.molbiopara.2006.01.009","article-title":"Plasmodium falciparum erythrocyte invasion: A conserved myosin associated complex","volume":"147","author":"Jones","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"2023072310112206400_bib53","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1111\/cmi.12283","article-title":"Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility","volume":"16","author":"Kan","year":"2014","journal-title":"Cell. Microbiol."},{"key":"2023072310112206400_bib54","doi-asserted-by":"publisher","first-page":"mcp.M116.058263","DOI":"10.1074\/mcp.M116.058263","article-title":"Proteomic analysis of the Plasmodium berghei gametocyte egressome and vesicular bioID of osmiophilic body proteins identifies MTRAP as an essential factor for parasite transmission","author":"Kehrer","year":"2016","journal-title":"Mol. Cell. Proteomics."},{"key":"2023072310112206400_bib55","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/0169-4758(88)90113-5","article-title":"Cell motility of sporozoan protozoa","volume":"4","author":"King","year":"1988","journal-title":"Parasitol. Today (Regul. Ed.)."},{"key":"2023072310112206400_bib56","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/cmi.12557","article-title":"The mechanics of malaria parasite invasion of the human erythrocyte\u2014towards a reassessment of the host cell contribution","volume":"18","author":"Koch","year":"2016","journal-title":"Cell. Microbiol."},{"key":"2023072310112206400_bib57","doi-asserted-by":"publisher","first-page":"e1003213","DOI":"10.1371\/journal.ppat.1003213","article-title":"An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes","volume":"9","author":"Kremer","year":"2013","journal-title":"PLoS Pathog."},{"key":"2023072310112206400_bib58","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1757-5036-3-6","article-title":"Geometric constrains for detecting short actin filaments by cryogenic electron tomography","volume":"3","author":"Kudryashev","year":"2010","journal-title":"PMC Biophys."},{"key":"2023072310112206400_bib59","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1111\/j.1462-5822.2012.01836.x","article-title":"Structural basis for chirality and directional motility of Plasmodium sporozoites","volume":"14","author":"Kudryashev","year":"2012","journal-title":"Cell. Microbiol."},{"key":"2023072310112206400_bib60","doi-asserted-by":"publisher","first-page":"633","DOI":"10.2307\/3277308","article-title":"Penetration of erythrocytes by merozoites of mammalian and avian malarial parasites","volume":"55","author":"Ladda","year":"1969","journal-title":"J. Parasitol."},{"key":"2023072310112206400_bib61","doi-asserted-by":"publisher","first-page":"4098","DOI":"10.1038\/ncomms5098","article-title":"Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites","volume":"5","author":"Lamarque","year":"2014","journal-title":"Nat. Commun."},{"key":"2023072310112206400_bib62","doi-asserted-by":"publisher","first-page":"e85763","DOI":"10.1371\/journal.pone.0085763","article-title":"Disruption of TgPHIL1 alters specific parameters of Toxoplasma gondii motility measured in a quantitative, three-dimensional live motility assay","volume":"9","author":"Leung","year":"2014","journal-title":"PLoS One."},{"key":"2023072310112206400_bib63","doi-asserted-by":"publisher","first-page":"aab3500","DOI":"10.1126\/science.aab3500","article-title":"Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics","volume":"349","author":"Li","year":"2015","journal-title":"Science."},{"key":"2023072310112206400_bib64","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1126\/science.aad8857","article-title":"Visualizing the molecular sociology at the HeLa cell nuclear periphery","volume":"351","author":"Mahamid","year":"2016","journal-title":"Science."},{"key":"2023072310112206400_bib65","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nature14044","article-title":"Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation","volume":"520","author":"Marsolier","year":"2015","journal-title":"Nature."},{"key":"2023072310112206400_bib66","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.mib.2013.05.002","article-title":"Invasion factors of apicomplexan parasites: Essential or redundant?","volume":"16","author":"Meissner","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"2023072310112206400_bib67","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1084\/jem.149.1.172","article-title":"Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation","volume":"149","author":"Miller","year":"1979","journal-title":"J. Exp. Med."},{"key":"2023072310112206400_bib68","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1242\/jcs.108.6.2457","article-title":"Invasion of Toxoplasma gondii occurs by active penetration of the host cell","volume":"108","author":"Morisaki","year":"1995","journal-title":"J. Cell Sci."},{"key":"2023072310112206400_bib69","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1128\/MMBR.66.1.21-38.2002","article-title":"Cytoskeleton of apicomplexan parasites","volume":"66","author":"Morrissette","year":"2002","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"2023072310112206400_bib70","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.chom.2009.11.007","article-title":"Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites","volume":"6","author":"M\u00fcnter","year":"2009","journal-title":"Cell Host Microbe."},{"key":"2023072310112206400_bib71","doi-asserted-by":"publisher","first-page":"e1002222","DOI":"10.1371\/journal.ppat.1002222","article-title":"Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex","volume":"7","author":"Nebl","year":"2011","journal-title":"PLoS Pathog."},{"key":"2023072310112206400_bib72","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/BF00927970","article-title":"Modes of entry of Toxoplasma gondii trophozoites into normal mouse peritoneal macrophage and HeLa cell monolayers. A phase-contrast microcinematographic study","volume":"60","author":"Nguyen","year":"1979","journal-title":"Z. Parasitenkd."},{"key":"2023072310112206400_bib73","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/s12936-015-0801-5","article-title":"Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites","volume":"14","author":"Olshina","year":"2015","journal-title":"Malar. J."},{"key":"2023072310112206400_bib74","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1046\/j.1365-2958.2002.03056.x","article-title":"\u2018The glideosome\u2019: A dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii","volume":"45","author":"Opitz","year":"2002","journal-title":"Mol. Microbiol."},{"key":"2023072310112206400_bib75","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1242\/jcs.111.13.1831","article-title":"Actomyosin motor in the merozoite of the malaria parasite, Plasmodium falciparum: Implications for red cell invasion","volume":"111","author":"Pinder","year":"1998","journal-title":"J. Cell Sci."},{"key":"2023072310112206400_bib76","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1021\/acsnano.5b06417","article-title":"Coupling of retrograde flow to force production during malaria parasite migration","volume":"10","author":"Quadt","year":"2016","journal-title":"ACS Nano."},{"key":"2023072310112206400_bib77","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1006\/jsbi.2001.4396","article-title":"Cryofracture electron microscopy of the ookinete pellicle of Plasmodium gallinaceum reveals the existence of novel pores in the alveolar membranes","volume":"135","author":"Raibaud","year":"2001","journal-title":"J. Struct. Biol."},{"key":"2023072310112206400_bib78","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.chom.2010.12.003","article-title":"Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte","volume":"9","author":"Riglar","year":"2011","journal-title":"Cell Host Microbe."},{"key":"2023072310112206400_bib79","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1242\/jcs.177741","article-title":"Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion","volume":"129","author":"Riglar","year":"2016","journal-title":"J. Cell Sci."},{"key":"2023072310112206400_bib80","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1242\/jcs.50.1.345","article-title":"The role of the cytoskeleton in the motility of coccidian sporozoites","volume":"50","author":"Russell","year":"1981","journal-title":"J. Cell Sci."},{"key":"2023072310112206400_bib81","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0020-7519(82)90020-0","article-title":"Three-dimensional study of the intact cytoskeleton of coccidian sporozoites","volume":"12","author":"Russell","year":"1982","journal-title":"Int. J. Parasitol."},{"key":"2023072310112206400_bib82","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/iai.20.3.739-743.1978","article-title":"Effect of cytochalasin D on Toxoplasma gondii cell entry","volume":"20","author":"Ryning","year":"1978","journal-title":"Infect. Immun."},{"key":"2023072310112206400_bib83","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1091\/mbc.E05-06-0512","article-title":"Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii","volume":"17","author":"Sahoo","year":"2006","journal-title":"Mol. Biol. Cell."},{"key":"2023072310112206400_bib84","first-page":"340","article-title":"Uber die Ursache der Fortschreitenden Bewegungder Gregarinen","volume":"58","author":"Schewiakoff","year":"1894","journal-title":"Z. Wiss. Zool."},{"key":"2023072310112206400_bib85","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jmb.2005.03.056","article-title":"Malaria parasite actin filaments are very short","volume":"349","author":"Schmitz","year":"2005","journal-title":"J. Mol. Biol."},{"key":"2023072310112206400_bib86","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S1471-4922(02)00015-6","article-title":"Cell invasion by Theileria sporozoites","volume":"19","author":"Shaw","year":"2003","journal-title":"Trends Parasitol."},{"key":"2023072310112206400_bib87","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.1073\/pnas.1315156111","article-title":"Toxoplasma aldolase is required for metabolism but dispensable for host-cell invasion","volume":"111","author":"Shen","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072310112206400_bib88","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1126\/science.1094717","article-title":"Intracellular parasite invasion strategies","volume":"304","author":"Sibley","year":"2004","journal-title":"Science."},{"key":"2023072310112206400_bib89","doi-asserted-by":"publisher","first-page":"e1002280","DOI":"10.1371\/journal.ppat.1002280","article-title":"Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites","volume":"7","author":"Skillman","year":"2011","journal-title":"PLoS Pathog."},{"key":"2023072310112206400_bib90","doi-asserted-by":"publisher","first-page":"e1002280","DOI":"10.1371\/journal.ppat.1002280","article-title":"Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites","volume":"7","author":"Skillman","year":"2011","journal-title":"PLoS Pathog."},{"key":"2023072310112206400_bib91","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1038\/ncomms3285","article-title":"The unusual dynamics of parasite actin result from isodesmic polymerization","volume":"4","author":"Skillman","year":"2013","journal-title":"Nat. Commun."},{"key":"2023072310112206400_bib92","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.pt.2004.09.009","article-title":"Molecular and functional aspects of parasite invasion","volume":"20","author":"Soldati","year":"2004","journal-title":"Trends Parasitol."},{"key":"2023072310112206400_bib93","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2307\/3281974","article-title":"Capping of immune complexes by sporozoites of Eimeria tenella","volume":"71","author":"Speer","year":"1985","journal-title":"J. Parasitol."},{"key":"2023072310112206400_bib94","doi-asserted-by":"publisher","first-page":"13275","DOI":"10.1073\/pnas.1110303108","article-title":"Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion","volume":"108","author":"Srinivasan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072310112206400_bib95","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1550-7408.1988.tb04115.x","article-title":"Malaria sporozoites leave behind trails of circumsporozoite protein during gliding motility","volume":"35","author":"Stewart","year":"1988","journal-title":"J. Protozool."},{"key":"2023072310112206400_bib96","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4269\/ajtmh.1986.35.37","article-title":"Rhoptry secretion of membranous whorls by Plasmodium falciparum merozoites","volume":"35","author":"Stewart","year":"1986","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2023072310112206400_bib97","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/ncb3350","article-title":"The molecular clutch model for mechanotransduction evolves","volume":"18","author":"Swaminathan","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"2023072310112206400_bib98","doi-asserted-by":"publisher","first-page":"501","DOI":"10.2471\/BLT.12.111732","article-title":"The global burden of congenital toxoplasmosis: A systematic review","volume":"91","author":"Torgerson","year":"2013","journal-title":"Bull. World Health Organ."},{"key":"2023072310112206400_bib99","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/j.1550-7408.1974.tb03693.x","article-title":"Studies on the motility of Plasmodium sporozoites","volume":"21","author":"Vanderberg","year":"1974","journal-title":"J. Protozool."},{"key":"2023072310112206400_bib100","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1111\/j.1462-5822.2004.00394.x","article-title":"Real-time, in vivo analysis of malaria ookinete locomotion and mosquito midgut invasion","volume":"6","author":"Vlachou","year":"2004","journal-title":"Cell. Microbiol."},{"key":"2023072310112206400_bib101","doi-asserted-by":"publisher","first-page":"e1004670","DOI":"10.1371\/journal.ppat.1004670","article-title":"Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes","volume":"11","author":"Weiss","year":"2015","journal-title":"PLoS Pathog."},{"key":"2023072310112206400_bib102","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0166-6851(88)90107-7","article-title":"Extremely diverged actin proteins in Plasmodium falciparum","volume":"30","author":"Wesseling","year":"1988","journal-title":"Mol. Biochem. Parasitol."},{"key":"2023072310112206400_bib103","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1091\/mbc.E02-08-0458","article-title":"Actin filament polymerization regulates gliding motility by apicomplexan parasites","volume":"14","author":"Wetzel","year":"2003","journal-title":"Mol. Biol. Cell."},{"key":"2023072310112206400_bib104","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S0140-6736(13)60024-0","article-title":"Malaria","volume":"383","author":"White","year":"2014","journal-title":"Lancet."},{"key":"2023072310112206400_bib105","doi-asserted-by":"publisher","first-page":"e06974","DOI":"10.7554\/eLife.06974","article-title":"Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites","volume":"4","author":"Woo","year":"2015","journal-title":"eLife."},{"key":"2023072310112206400_bib106","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.cell.2007.10.049","article-title":"Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes","volume":"131","author":"Yeoh","year":"2007","journal-title":"Cell."},{"key":"2023072310112206400_bib107","doi-asserted-by":"publisher","first-page":"e46160","DOI":"10.1371\/journal.pone.0046160","article-title":"Subcompartmentalisation of proteins in the rhoptries correlates with ordered events of erythrocyte invasion by the blood stage malaria parasite","volume":"7","author":"Zuccala","year":"2012","journal-title":"PLoS One."},{"key":"2023072310112206400_bib108","doi-asserted-by":"publisher","first-page":"19766","DOI":"10.1038\/srep19766","article-title":"Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton","volume":"6","author":"Zuccala","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1083\/jcb.201605100","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/214\/5\/507\/1602829\/jcb_201605100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/214\/5\/507\/1602829\/jcb_201605100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T06:11:49Z","timestamp":1690092709000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/214\/5\/507\/38718\/Reassessing-the-mechanics-of-parasite-motility-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,29]]},"references-count":108,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,8,29]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201605100","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,29]]}}}