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By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bronchial epithelial cell monolayers, we identified GEFs that are required for collective migration at large, such as SOS1 and \u03b2-PIX, and RHOA GEFs that are implicated in intercellular communication. Down-regulation of the latter GEFs differentially enhanced front-to-back propagation of guidance cues through the monolayer and was mirrored by down-regulation of RHOA expression and myosin II activity. Phenotype-based clustering of knockdown behaviors identified RHOA-ARHGEF18 and ARHGEF3-ARHGEF28-ARHGEF11 clusters, indicating that the latter may signal through other RHO-family GTPases. Indeed, knockdown of RHOC produced an intermediate between the two phenotypes. We conclude that for effective collective migration, the RHOA-GEFs \u2192 RHOA\/C \u2192 actomyosin pathways must be optimally tuned to compromise between generation of motility forces and restriction of intercellular communication.<\/jats:p>","DOI":"10.1083\/jcb.201609095","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T10:10:10Z","timestamp":1494929410000},"page":"1543-1556","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration"],"prefix":"10.1083","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-5478","authenticated-orcid":true,"given":"Assaf","family":"Zaritsky","sequence":"first","affiliation":[{"name":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 1"},{"name":"Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Yu","family":"Tseng","sequence":"additional","affiliation":[{"name":"Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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