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Toxoplasma multiplies in a membrane-bound parasitophorous vacuole (PV) that interacts with mammalian host organelles and intercepts Golgi Rab vesicles to acquire sphingolipids. The mechanisms of host vesicle internalization and processing within the PV remain undefined. We demonstrate that Toxoplasma sequesters a broad range of Rab vesicles into the PV. Correlative light and electron microscopy analysis of infected cells illustrates that intravacuolar Rab1A vesicles are surrounded by the PV membrane, suggesting a phagocytic-like process for vesicle engulfment. Rab11A vesicles concentrate to an intravacuolar network (IVN), but this is reduced in \u0394gra2 and \u0394gra2\u0394gra6 parasites, suggesting that tubules stabilized by the TgGRA2 and TgGRA6 proteins secreted by the parasite within the PV contribute to host vesicle sequestration. Overexpression of a phospholipase TgLCAT, which is localized to the IVN, results in a decrease in the number of intravacuolar GFP-Rab11A vesicles, suggesting that TgLCAT controls lipolytic degradation of Rab vesicles for cargo release.<\/jats:p>","DOI":"10.1083\/jcb.201701108","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T08:55:09Z","timestamp":1508921709000},"page":"4235-4254","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":96,"title":["The parasite\n                    <i>Toxoplasma<\/i>\n                    sequesters diverse Rab host vesicles within an intravacuolar network"],"prefix":"10.1083","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-7377","authenticated-orcid":true,"given":"Julia D.","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8213-3621","authenticated-orcid":true,"given":"Sabrina J.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-9984","authenticated-orcid":true,"given":"Corey","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0533-2912","authenticated-orcid":true,"given":"Karen","family":"Ehrenman","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8686-4771","authenticated-orcid":true,"given":"Eric J.","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-089X","authenticated-orcid":true,"given":"Ru-ching","family":"Hsia","sequence":"additional","affiliation":[{"name":"Electron Microscopy Core Imaging Facility, University of Maryland Baltimore, Baltimore, MD 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-2362","authenticated-orcid":true,"given":"Isabelle","family":"Coppens","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2017,10,25]]},"reference":[{"key":"2023072309122702100_bib1","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1126\/science.289.5478.444","article-title":"Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion","volume":"289","author":"Allan","year":"2000","journal-title":"Science."},{"key":"2023072309122702100_bib2","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev-cellbio-100913-013439","article-title":"Bacterial pathogen manipulation of host membrane trafficking","volume":"30","author":"Asrat","year":"2014","journal-title":"Annu. 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