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Yet, little is known about the molecules that drive these processes and may functionally connect them to the transient calcium pulses observed in restricted areas in the forming dendritic arbor. Here we demonstrate that Cordon-Bleu (Cobl)\u2013like, an uncharacterized protein suggested to represent a very distantly related, evolutionary ancestor of the actin nucleator Cobl, despite having only a single G-actin\u2013binding Wiskott\u2013Aldrich syndrome protein Homology 2 (WH2) domain, massively promoted the formation of F-actin\u2013rich membrane ruffles of COS-7 cells and of dendritic branches of neurons. Cobl-like hereby integrates WH2 domain functions with those of the F-actin\u2013binding protein Abp1. Cobl-like\u2013mediated dendritic branching is dependent on Abp1 as well as on Ca2+\/calmodulin (CaM) signaling and CaM association. Calcium signaling leads to a promotion of complex formation with Cobl-like\u2019s cofactor Abp1. Thus, Ca2+\/CaM control of actin dynamics seems to be a much more broadly used principle in cell biology than previously thought.<\/jats:p>","DOI":"10.1083\/jcb.201704071","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T18:37:46Z","timestamp":1513103866000},"page":"211-230","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Cobl-like promotes actin filament formation and dendritic branching using only a single WH2 domain"],"prefix":"10.1083","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-2560","authenticated-orcid":true,"given":"Maryam","family":"Izadi","sequence":"first","affiliation":[{"name":"Institute of Biochemistry I, Jena University Hospital\/Friedrich-Schiller-University Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schlobinski","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry I, Jena University Hospital\/Friedrich-Schiller-University Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lahr","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry I, Jena University Hospital\/Friedrich-Schiller-University Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Schwintzer","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry I, Jena University Hospital\/Friedrich-Schiller-University Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5743-5764","authenticated-orcid":true,"given":"Britta","family":"Qualmann","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry I, Jena University Hospital\/Friedrich-Schiller-University Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5967-0744","authenticated-orcid":true,"given":"Michael M.","family":"Kessels","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry I, Jena University Hospital\/Friedrich-Schiller-University Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"2023072316494521100_bib1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.cell.2007.08.030","article-title":"Cordon-bleu is an actin nucleation factor and controls neuronal morphology","volume":"131","author":"Ahuja","year":"2007","journal-title":"Cell."},{"key":"2023072316494521100_bib2","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1091\/mbc.E05-01-0076","article-title":"EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling","volume":"16","author":"Braun","year":"2005","journal-title":"Mol. 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