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In this issue, Oldenburg et al. (2017. J. Cell Biol. https:\/\/doi.org\/10.1083\/jcb.201701043) demonstrate that this mutation impairs the ability of lamin A to repress the anti-adipogenic miR-335, providing a potential molecular mechanism for the disease.<\/jats:p>","DOI":"10.1083\/jcb.201707090","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T14:35:14Z","timestamp":1502807714000},"page":"2607-2610","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis"],"prefix":"10.1083","volume":"216","author":[{"given":"Eman","family":"Elzeneini","sequence":"first","affiliation":[{"name":"Paul Gerson Unna Group, Skin Homeostasis and Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6383-6292","authenticated-orcid":true,"given":"Sara A.","family":"Wickstr\u00f6m","sequence":"additional","affiliation":[{"name":"Paul Gerson Unna Group, Skin Homeostasis and Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany 1"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2017,8,15]]},"reference":[{"key":"2023072316450081800_bib1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1146\/annurev-biochem-060614-034115","article-title":"Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation","volume":"84","author":"Gruenbaum","year":"2015","journal-title":"Annu. 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