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Here, we identify a key role for the Wave complex proteins ABI1 and Wave2 in regulating signals that control epidermal shape and growth. In utero RNAi-mediated silencing of Abi1 or Wasf2 induced cellular hyperproliferation and defects in architecture of the interfollicular epidermis (IFE) and delayed hair follicle growth. Unexpectedly, SOX9, a hair follicle growth regulator, was aberrantly expressed throughout the IFE of the mutant embryos, and its forced overexpression mimicked the Wave complex loss-of-function phenotype. Moreover, Wnt signaling, which regulates SOX9+ cell specification, was up-regulated in Wave complex loss-of-function IFE. Importantly, we show that the Wave complex regulates filamentous actin content and that a decrease in actin levels is sufficient to elevate Wnt\/\u03b2-catenin signaling. Our results identify a novel role for Wave complex\u2013 and actin-regulated signaling via Wnt and SOX9 in skin development.<\/jats:p>","DOI":"10.1083\/jcb.201807216","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T17:55:13Z","timestamp":1552499713000},"page":"1390-1406","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt\u2013Sox9 signaling"],"prefix":"10.1083","volume":"218","author":[{"given":"Jonathan","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaul","family":"Raviv","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Adir","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-5051","authenticated-orcid":true,"given":"Krishnanand","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arad","family":"Soffer","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7801-3499","authenticated-orcid":true,"given":"Chen","family":"Luxenburg","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2019,3,13]]},"reference":[{"key":"2023072315350232300_bib1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.devcel.2014.02.003","article-title":"Directional cell migration, but not proliferation, drives hair placode morphogenesis","volume":"28","author":"Ahtiainen","year":"2014","journal-title":"Dev. 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