{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:46:50Z","timestamp":1772794010470,"version":"3.50.1"},"reference-count":78,"publisher":"Rockefeller University Press","issue":"8","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2020,2,2]],"date-time":"2020-02-02T00:00:00Z","timestamp":1580601600000},"content-version":"vor","delay-in-days":200,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001388","name":"Wenner-Gren Stiftelserna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000848","name":"University of Edinburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,8,5]]},"abstract":"<jats:p>Epithelial organ size and shape depend on cell shape changes, cell\u2013matrix communication, and apical membrane growth. The Drosophila melanogaster embryonic tracheal network is an excellent model to study these processes. Here, we show that the transcriptional coactivator of the Hippo pathway, Yorkie (YAP\/TAZ in vertebrates), plays distinct roles in the developing Drosophila airways. Yorkie exerts a cytoplasmic function by binding Drosophila Twinstar, the orthologue of the vertebrate actin-severing protein Cofilin, to regulate F-actin levels and apical cell membrane size, which are required for proper tracheal tube elongation. Second, Yorkie controls water tightness of tracheal tubes by transcriptional regulation of the \u03b4-aminolevulinate synthase gene (Alas). We conclude that Yorkie has a dual role in tracheal development to ensure proper tracheal growth and functionality.<\/jats:p>","DOI":"10.1083\/jcb.201809121","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T14:35:22Z","timestamp":1563374122000},"page":"2762-2781","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Yorkie controls tube length and apical barrier integrity during airway development"],"prefix":"10.1083","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8514-4502","authenticated-orcid":true,"given":"Kassiani","family":"Skouloudaki","sequence":"first","affiliation":[{"name":"Max-Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9785-9641","authenticated-orcid":true,"given":"Dilan","family":"Khalili","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-1351","authenticated-orcid":true,"given":"Vasilios","family":"Tsarouhas","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-6040","authenticated-orcid":true,"given":"Christos","family":"Samakovlis","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden 3"},{"name":"Excellence Cluster Cardio-Pulmonary System, University of Giessen, Giessen, Germany 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Tomancak","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-9135","authenticated-orcid":true,"given":"Elisabeth","family":"Knust","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0914-3051","authenticated-orcid":false,"given":"Dimitrios K.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany 1"},{"name":"Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK 2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"2023080923240485200_bib1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.molcel.2006.08.006","article-title":"Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF\/cofilin","volume":"24","author":"Andrianantoandro","year":"2006","journal-title":"Mol. Cell."},{"key":"2023080923240485200_bib2","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2013.07.042","article-title":"A mechanical checkpoint controls multicellular growth through YAP\/TAZ regulation by actin-processing factors","volume":"154","author":"Aragona","year":"2013","journal-title":"Cell."},{"key":"2023080923240485200_bib3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1471-213X-8-55","article-title":"On the role of the MAGUK proteins encoded by Drosophila varicose during embryonic and postembryonic development","volume":"8","author":"Bachmann","year":"2008","journal-title":"BMC Dev. Biol."},{"key":"2023080923240485200_bib4","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev.cellbio.15.1.185","article-title":"Proteins of the ADF\/cofilin family: essential regulators of actin dynamics","volume":"15","author":"Bamburg","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2023080923240485200_bib5","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1242\/dev.127.15.3271","article-title":"Genetic control of epithelial tube size in the Drosophila tracheal system","volume":"127","author":"Beitel","year":"2000","journal-title":"Development."},{"key":"2023080923240485200_bib6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.tcb.2010.01.001","article-title":"ADF\/cofilin: a functional node in cell biology","volume":"20","author":"Bernstein","year":"2010","journal-title":"Trends Cell Biol."},{"key":"2023080923240485200_bib7","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1083\/jcb.201601098","article-title":"Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release","volume":"216","author":"Bruckner","year":"2017","journal-title":"J. Cell Biol."},{"key":"2023080923240485200_bib8","doi-asserted-by":"publisher","first-page":"134","DOI":"10.5483\/BMBRep.2018.51.3.027","article-title":"Upstream paths for Hippo signaling in Drosophila organ development","volume":"51","author":"Choi","year":"2018","journal-title":"BMB Rep."},{"key":"2023080923240485200_bib9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.gde.2015.02.009","article-title":"Shaping of biological tubes by mechanical interaction of cell and extracellular matrix","volume":"32","author":"Dong","year":"2015","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2023080923240485200_bib10","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.celrep.2014.03.066","article-title":"Balance between apical membrane growth and luminal matrix resistance determines epithelial tubule shape","volume":"7","author":"Dong","year":"2014","journal-title":"Cell Reports."},{"key":"2023080923240485200_bib11","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1083\/jcb.200103132","article-title":"Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase\/peroxidase with homology to the phagocyte oxidase subunit gp91phox","volume":"154","author":"Edens","year":"2001","journal-title":"J. Cell Biol."},{"key":"2023080923240485200_bib12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ceb.2018.02.003","article-title":"Evolution of mechanotransduction via YAP\/TAZ in animal epithelia","volume":"51","author":"Elbediwy","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023080923240485200_bib13","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1242\/dev.063545","article-title":"Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila","volume":"138","author":"Fern\u00e1ndez","year":"2011","journal-title":"Development."},{"key":"2023080923240485200_bib14","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1083\/jcb.201705107","article-title":"The apical scaffold big bang binds to spectrins and regulates the growth of Drosophila melanogaster wing discs","volume":"217","author":"Forest","year":"2018","journal-title":"J. Cell Biol."},{"key":"2023080923240485200_bib15","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/ncb2456","article-title":"Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila","volume":"14","author":"F\u00f6rster","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"2023080923240485200_bib16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ceb.2017.10.006","article-title":"Upstairs, downstairs: spatial regulation of Hippo signalling","volume":"51","author":"Fulford","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023080923240485200_bib17","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1752-8062.2011.00312.x","article-title":"Molecular analysis of cyst fluid aspiration in the diagnosis and risk assessment of cystic lesions of the pancreas","volume":"5","author":"Garud","year":"2012","journal-title":"Clin. Transl. Sci."},{"key":"2023080923240485200_bib18","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1534\/genetics.113.152710","article-title":"Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease","volume":"194","author":"Gratz","year":"2013","journal-title":"Genetics"},{"key":"2023080923240485200_bib19","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1016\/j.cub.2003.11.054","article-title":"Shroom induces apical constriction and is required for hingepoint formation during neural tube closure","volume":"13","author":"Haigo","year":"2003","journal-title":"Curr. Biol."},{"key":"2023080923240485200_bib20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1242\/dev.045500","article-title":"Hippo signaling: growth control and beyond","volume":"138","author":"Halder","year":"2011","journal-title":"Development."},{"key":"2023080923240485200_bib21","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1534\/genetics.117.300167","article-title":"Development and Function of the Drosophila Tracheal System","volume":"209","author":"Hayashi","year":"2018","journal-title":"Genetics."},{"key":"2023080923240485200_bib22","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/S1097-2765(02)00496-3","article-title":"Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation","volume":"9","author":"Hu","year":"2002","journal-title":"Mol. Cell."},{"key":"2023080923240485200_bib23","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","article-title":"The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP","volume":"122","author":"Huang","year":"2005","journal-title":"Cell."},{"key":"2023080923240485200_bib24","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1242\/dev.070680","article-title":"Tubulogenesis","volume":"140","author":"Iruela-Arispe","year":"2013","journal-title":"Development."},{"key":"2023080923240485200_bib25","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.devcel.2015.11.018","article-title":"Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover","volume":"35","author":"Jodoin","year":"2015","journal-title":"Dev. Cell."},{"key":"2023080923240485200_bib26","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1074\/mcp.T500024-MCP200","article-title":"Phosphate-binding tag, a new tool to visualize phosphorylated proteins","volume":"5","author":"Kinoshita","year":"2006","journal-title":"Mol. Cell. Proteomics."},{"key":"2023080923240485200_bib27","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1091\/mbc.e07-12-1286","article-title":"Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation","volume":"19","author":"Kinoshita","year":"2008","journal-title":"Mol. Biol. Cell."},{"key":"2023080923240485200_bib28","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1083\/jcb.201101035","article-title":"Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension","volume":"193","author":"Kiuchi","year":"2011","journal-title":"J. Cell Biol."},{"key":"2023080923240485200_bib29","doi-asserted-by":"publisher","first-page":"5144","DOI":"10.1038\/onc.2016.46","article-title":"Twinstar\/cofilin is required for regulation of epithelial integrity and tissue growth in Drosophila","volume":"35","author":"Ko","year":"2016","journal-title":"Oncogene."},{"key":"2023080923240485200_bib30","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.devcel.2006.06.001","article-title":"The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size","volume":"11","author":"Laprise","year":"2006","journal-title":"Dev. Cell."},{"key":"2023080923240485200_bib31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cub.2009.11.017","article-title":"Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway","volume":"20","author":"Laprise","year":"2010","journal-title":"Curr. Biol."},{"key":"2023080923240485200_bib32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ydbio.2007.08.010","article-title":"Actomyosin contractility and microtubules drive apical constriction in Xenopus bottle cells","volume":"311","author":"Lee","year":"2007","journal-title":"Dev. Biol."},{"key":"2023080923240485200_bib33","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1242\/dev.00917","article-title":"Lachesin is a component of a septate junction-based mechanism that controls tube size and epithelial integrity in the Drosophila tracheal system","volume":"131","author":"Llimargas","year":"2004","journal-title":"Development."},{"key":"2023080923240485200_bib34","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.cub.2005.11.072","article-title":"serpentine and vermiform encode matrix proteins with chitin binding and deacetylation domains that limit tracheal tube length in Drosophila","volume":"16","author":"Luschnig","year":"2006","journal-title":"Curr. Biol."},{"key":"2023080923240485200_bib35","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1091\/mbc.6.11.1423","article-title":"The ADF\/cofilin proteins: stimulus-responsive modulators of actin dynamics","volume":"6","author":"Moon","year":"1995","journal-title":"Mol. Biol. Cell."},{"key":"2023080923240485200_bib36","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ibmb.2010.03.003","article-title":"Recent advances in understanding mechanisms of insect cuticle differentiation","volume":"40","author":"Moussian","year":"2010","journal-title":"Insect Biochem. Mol. Biol."},{"key":"2023080923240485200_bib37","doi-asserted-by":"publisher","DOI":"10.1209\/0295-5075\/83\/46001","article-title":"Precise measurement of diffusion by multi-color dual-focus fluorescence correlation spectroscopy","author":"Muller","year":"2008","journal-title":"Europhys. Lett."},{"key":"2023080923240485200_bib38","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1101\/gad.183061.111","article-title":"Control of mitochondrial structure and function by the Yorkie\/YAP oncogenic pathway","volume":"26","author":"Nagaraj","year":"2012","journal-title":"Genes Dev."},{"key":"2023080923240485200_bib39","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/ncb2467","article-title":"Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size","volume":"14","author":"Nelson","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"2023080923240485200_bib40","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.neuron.2004.11.014","article-title":"Rho GTPases regulate axon growth through convergent and divergent signaling pathways","volume":"44","author":"Ng","year":"2004","journal-title":"Neuron."},{"key":"2023080923240485200_bib41","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1242\/dev.015255","article-title":"In vivo regulation of Yorkie phosphorylation and localization","volume":"135","author":"Oh","year":"2008","journal-title":"Development."},{"key":"2023080923240485200_bib42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.devcel.2010.12.002","article-title":"Cooperative regulation of growth by Yorkie and Mad through bantam","volume":"20","author":"Oh","year":"2011","journal-title":"Dev. Cell."},{"key":"2023080923240485200_bib43","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.scitotenv.2018.04.004","article-title":"Lead modulated Heme synthesis inducing oxidative stress mediated Genotoxicity in Drosophila melanogaster","volume":"634","author":"Olakkaran","year":"2018","journal-title":"Sci. Total Environ."},{"key":"2023080923240485200_bib44","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/dvdy.24356","article-title":"Drosophila chitinous aECM and its cellular interactions during tracheal development","volume":"245","author":"\u00d6zt\u00fcrk-\u00c7olak","year":"2016","journal-title":"Dev. Dyn."},{"key":"2023080923240485200_bib45","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1242\/dev.168179","article-title":"Control of Hox transcription factor concentration and cell-to-cell variability by an auto-regulatory switch","volume":"146","author":"Papadopoulos","year":"2019","journal-title":"Development."},{"key":"2023080923240485200_bib46","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.mcna.2012.02.002","article-title":"Thyroid nodules","volume":"96","author":"Popoveniuc","year":"2012","journal-title":"Med. Clin. North Am."},{"key":"2023080923240485200_bib47","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.7863\/jum.2010.29.11.1617","article-title":"Cystic breast lesions: sonographic findings and clinical management","volume":"29","author":"Rinaldi","year":"2010","journal-title":"J. Ultrasound Med."},{"key":"2023080923240485200_bib48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101609","article-title":"Non-canonical roles for Yorkie and Drosophila Inhibitor of Apoptosis 1 in epithelial tube size control","volume":"9","author":"Robbins","year":"2014","journal-title":"PLoS One."},{"key":"2023080923240485200_bib49","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/ncb795","article-title":"Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1","volume":"4","author":"Ryoo","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"2023080923240485200_bib50","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1242\/dev.122.5.1395","article-title":"Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events","volume":"122","author":"Samakovlis","year":"1996","journal-title":"Development."},{"key":"2023080923240485200_bib51","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1038\/emboj.2011.157","article-title":"Modulating F-actin organization induces organ growth by affecting the Hippo pathway","volume":"30","author":"Sansores-Garcia","year":"2011","journal-title":"EMBO J."},{"key":"2023080923240485200_bib52","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods."},{"key":"2023080923240485200_bib53","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.cub.2014.06.029","article-title":"Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin","volume":"24","author":"Schottenfeld-Roames","year":"2014","journal-title":"Curr. Biol."},{"key":"2023080923240485200_bib54","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.semcdb.2012.06.001","article-title":"Regulation of the Hippo pathway by cell architecture and mechanical signals","volume":"23","author":"Schroeder","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"2023080923240485200_bib55","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ejcb.2011.11.005","article-title":"\u03b4-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva","volume":"91","author":"Shaik","year":"2012","journal-title":"Eur. J. Cell Biol."},{"key":"2023080923240485200_bib56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035735","article-title":"YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation","volume":"7","author":"Skouloudaki","year":"2012","journal-title":"PLoS One."},{"key":"2023080923240485200_bib57","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1038\/nmeth947","article-title":"Direct observation of individual endogenous protein complexes in situ by proximity ligation","volume":"3","author":"S\u00f6derberg","year":"2006","journal-title":"Nat. Methods."},{"key":"2023080923240485200_bib58","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.ydbio.2015.03.022","article-title":"Cell shape change and invagination of the cephalic furrow involves reorganization of F-actin","volume":"402","author":"Spencer","year":"2015","journal-title":"Dev. Biol."},{"key":"2023080923240485200_bib59","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/MNH.0b013e32835011a7","article-title":"Polycystic kidney disease: a 2011 update","volume":"21","author":"Steinman","year":"2012","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"2023080923240485200_bib60","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.devcel.2017.02.004","article-title":"Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded","volume":"40","author":"Su","year":"2017","journal-title":"Dev. Cell."},{"key":"2023080923240485200_bib61","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.tcb.2016.05.003","article-title":"Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network","volume":"26","author":"Sun","year":"2016","journal-title":"Trends Cell Biol."},{"key":"2023080923240485200_bib62","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/ncb2111","article-title":"Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila","volume":"12","author":"Tiklov\u00e1","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"2023080923240485200_bib63","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.devcel.2005.07.012","article-title":"A transient luminal chitinous matrix is required to model epithelial tube diameter in the Drosophila trachea","volume":"9","author":"Tonning","year":"2005","journal-title":"Dev. Cell."},{"key":"2023080923240485200_bib64","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"2023080923240485200_bib65","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.devcel.2007.06.008","article-title":"Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila","volume":"13","author":"Tsarouhas","year":"2007","journal-title":"Dev. Cell."},{"key":"2023080923240485200_bib66","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1083\/jcb.201705104","article-title":"Drosophila Big bang regulates the apical cytocortex and wing growth through junctional tension","volume":"217","author":"Tsoumpekos","year":"2018","journal-title":"J. Cell Biol."},{"key":"2023080923240485200_bib67","doi-asserted-by":"publisher","first-page":"18176","DOI":"10.1073\/pnas.0809250105","article-title":"Quantitative single-molecule imaging by confocal laser scanning microscopy","volume":"105","author":"Vukojevic","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023080923240485200_bib68","doi-asserted-by":"publisher","first-page":"4093","DOI":"10.1073\/pnas.0914612107","article-title":"Quantitative study of synthetic Hox transcription factor-DNA interactions in live cells","volume":"107","author":"Vukojevic","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023080923240485200_bib69","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00018-004-4305-7","article-title":"Study of molecular events in cells by fluorescence correlation spectroscopy","volume":"62","author":"Vukojevi\u0107","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"2023080923240485200_bib70","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1083\/jcb.200108022","article-title":"Twinfilin is required for actin-dependent developmental processes in Drosophila","volume":"155","author":"Wahlstr\u00f6m","year":"2001","journal-title":"J. Cell Biol."},{"key":"2023080923240485200_bib71","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cub.2005.11.074","article-title":"Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila trachea","volume":"16","author":"Wang","year":"2006","journal-title":"Curr. Biol."},{"key":"2023080923240485200_bib72","doi-asserted-by":"publisher","first-page":"4364","DOI":"10.1074\/jbc.C110.205401","article-title":"Angiomotin-like proteins associate with and negatively regulate YAP1","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2023080923240485200_bib73","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1083\/jcb.200309134","article-title":"Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control","volume":"164","author":"Wu","year":"2004","journal-title":"J. Cell Biol."},{"key":"2023080923240485200_bib74","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.devcel.2018.06.017","article-title":"Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner","volume":"46","author":"Xu","year":"2018","journal-title":"Dev. Cell."},{"key":"2023080923240485200_bib75","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1242\/dev.143297","article-title":"Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl","volume":"144","author":"Yao","year":"2017","journal-title":"Development."},{"key":"2023080923240485200_bib76","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/ncb1368","article-title":"The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis","volume":"8","author":"Zhang","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"2023080923240485200_bib77","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1101\/gad.2000111","article-title":"Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein","volume":"25","author":"Zhao","year":"2011","journal-title":"Genes Dev."},{"key":"2023080923240485200_bib78","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00441-013-1673-z","article-title":"Novel mechanisms of tube-size regulation revealed by the Drosophila trachea","volume":"354","author":"Zuo","year":"2013","journal-title":"Cell Tissue Res."}],"updated-by":[{"DOI":"10.1083\/jcb.20180912104072023c","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000}}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/218\/8\/2762\/1916504\/jcb_201809121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/218\/8\/2762\/1916504\/jcb_201809121.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T19:24:32Z","timestamp":1691609072000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/218\/8\/2762\/120782\/Yorkie-controls-tube-length-and-apical-barrier"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":78,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8,5]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201809121","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736217766.793580467","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/532325","asserted-by":"object"}]},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,17]]}}}