{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:13:57Z","timestamp":1791688437332,"version":"4.3.4"},"reference-count":65,"publisher":"Rockefeller University Press","issue":"8","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2020,2,2]],"date-time":"2020-02-02T00:00:00Z","timestamp":1580601600000},"content-version":"vor","delay-in-days":226,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,8,5]]},"abstract":"<jats:p>Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various organelles including peroxisomes. Here, we show that the hereditary spastic paraplegia protein M1 Spastin, a membrane-bound AAA ATPase found on LDs, coordinates fatty acid (FA) trafficking from LDs to peroxisomes through two interrelated mechanisms. First, M1 Spastin forms a tethering complex with peroxisomal ABCD1 to promote LD\u2013peroxisome contact formation. Second, M1 Spastin recruits the membrane-shaping ESCRT-III proteins IST1 and CHMP1B to LDs via its MIT domain to facilitate LD-to-peroxisome FA trafficking, possibly through IST1- and CHMP1B-dependent modifications in LD membrane morphology. Furthermore, LD-to-peroxisome FA trafficking mediated by M1 Spastin is required to relieve LDs of lipid peroxidation. M1 Spastin\u2019s dual roles in tethering LDs to peroxisomes and in recruiting ESCRT-III components to LD\u2013peroxisome contact sites for FA trafficking may underlie the pathogenesis of diseases associated with defective FA metabolism in LDs and peroxisomes.<\/jats:p>","DOI":"10.1083\/jcb.201902061","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T15:45:15Z","timestamp":1561131915000},"page":"2583-2599","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":204,"title":["Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III"],"prefix":"10.1083","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-2243","authenticated-orcid":true,"given":"Chi-Lun","family":"Chang","sequence":"first","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1694-4420","authenticated-orcid":true,"given":"Aubrey V.","family":"Weigel","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-8626","authenticated-orcid":true,"given":"Maria S.","family":"Ioannou","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Amalia","family":"Pasolli","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8564-7836","authenticated-orcid":true,"given":"C. Shan","family":"Xu","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Peale","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleb","family":"Shtengel","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3576-8664","authenticated-orcid":true,"given":"Melanie","family":"Freeman","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-1533","authenticated-orcid":true,"given":"Harald F.","family":"Hess","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-9655","authenticated-orcid":true,"given":"Craig","family":"Blackstone","sequence":"additional","affiliation":[{"name":"Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-3501","authenticated-orcid":true,"given":"Jennifer","family":"Lippincott-Schwartz","sequence":"additional","affiliation":[{"name":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"2023072317370281500_bib1","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1091\/mbc.e08-05-0474","article-title":"Essential role of hIST1 in cytokinesis","volume":"20","author":"Agromayor","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"2023072317370281500_bib2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/ng0997-49","article-title":"A mouse model for Zellweger syndrome","volume":"17","author":"Baes","year":"1997","journal-title":"Nat. Genet."},{"key":"2023072317370281500_bib3","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.jns.2016.03.018","article-title":"Genetic background of the hereditary spastic paraplegia phenotypes in Hungary - An analysis of 58 probands","volume":"364","author":"Balicza","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"2023072317370281500_bib4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.devcel.2017.11.020","article-title":"A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes","volume":"44","author":"Bersuker","year":"2018","journal-title":"Dev. Cell."},{"key":"2023072317370281500_bib5","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1083\/jcb.200511125","article-title":"An intimate collaboration between peroxisomes and lipid bodies","volume":"173","author":"Binns","year":"2006","journal-title":"J. Cell Biol."},{"key":"2023072317370281500_bib6","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.conb.2018.04.025","article-title":"Converging cellular themes for the hereditary spastic paraplegias","volume":"51","author":"Blackstone","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"2023072317370281500_bib7","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1189\/jlb.0903442","article-title":"Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene","volume":"75","author":"Burnett","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"2023072317370281500_bib8","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1365-2818.2008.01984.x","article-title":"Freeze-substitution: the addition of water to polar solvents enhances the retention of structure and acts at temperatures around -60 degrees C","volume":"230","author":"Buser","year":"2008","journal-title":"J. Microsc."},{"key":"2023072317370281500_bib9","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.yexcr.2005.06.009","article-title":"Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus","volume":"309","author":"Claudiani","year":"2005","journal-title":"Exp. Cell Res."},{"key":"2023072317370281500_bib10","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1600-0854.2008.00847.x","article-title":"Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion","volume":"10","author":"Connell","year":"2009","journal-title":"Traffic."},{"key":"2023072317370281500_bib11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1750-1172-7-51","article-title":"X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management","volume":"7","author":"Engelen","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"key":"2023072317370281500_bib12","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1083\/jcb.200409058","article-title":"Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing","volume":"168","author":"Evans","year":"2005","journal-title":"J. Cell Biol."},{"key":"2023072317370281500_bib13","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/humu.22521","article-title":"Functional mutation analysis provides evidence for a role of REEP1 in lipid droplet biology","volume":"35","author":"Falk","year":"2014","journal-title":"Hum. Mutat."},{"key":"2023072317370281500_bib14","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.nut.2006.04.008","article-title":"Proteolytic and lipolytic responses to starvation","volume":"22","author":"Finn","year":"2006","journal-title":"Nutrition."},{"key":"2023072317370281500_bib15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1174","article-title":"Single-pot enzymatic synthesis of Dicer-substrate siRNAs","volume":"40","author":"Guiley","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2023072317370281500_bib16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.ceb.2015.02.002","article-title":"The life cycle of lipid droplets","volume":"33","author":"Hashemi","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072317370281500_bib17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/BF01288364","article-title":"Direct interaction between glyoxysomes and lipid bodies in cotyledons of the Arabidopsis thaliana ped1 mutant","volume":"218","author":"Hayashi","year":"2001","journal-title":"Protoplasma."},{"key":"2023072317370281500_bib18","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201898947","article-title":"The assembly of lipid droplets and their roles in challenged cells","volume":"37","author":"Henne","year":"2018","journal-title":"EMBO J."},{"key":"2023072317370281500_bib19","doi-asserted-by":"publisher","first-page":"14924","DOI":"10.1073\/pnas.1413706111","article-title":"The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase","volume":"111","author":"Inloes","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072317370281500_bib20","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00418-018-1722-5","article-title":"The peroxisome: an update on mysteries 2.0","volume":"150","author":"Islinger","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"2023072317370281500_bib21","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.celrep.2013.04.015","article-title":"A conserved role for atlastin GTPases in regulating lipid droplet size","volume":"3","author":"Klemm","year":"2013","journal-title":"Cell Reports."},{"key":"2023072317370281500_bib22","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.tcb.2016.02.007","article-title":"Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets","volume":"26","author":"Kory","year":"2016","journal-title":"Trends Cell Biol."},{"key":"2023072317370281500_bib23","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jns.2015.05.031","article-title":"A novel ABCD1 mutation detected by next generation sequencing in presumed hereditary spastic paraplegia: A 30-year diagnostic delay caused by misleading biochemical findings","volume":"355","author":"Koutsis","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"2023072317370281500_bib24","author":"Leff","year":"2010"},{"key":"2023072317370281500_bib25","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013300","article-title":"Nonvesicular lipid transfer from the endoplasmic reticulum","volume":"4","author":"Lev","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2023072317370281500_bib26","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.cub.2005.05.055","article-title":"STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx","volume":"15","author":"Liou","year":"2005","journal-title":"Curr. Biol."},{"key":"2023072317370281500_bib27","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.cmet.2014.01.002","article-title":"Peroxisomes: a nexus for lipid metabolism and cellular signaling","volume":"19","author":"Lodhi","year":"2014","journal-title":"Cell Metab."},{"key":"2023072317370281500_bib28","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1212\/WNL.45.6.1101","article-title":"X-linked adrenoleukodystrophy presenting as neurologically pure familial spastic paraparesis","volume":"45","author":"Maris","year":"1995","journal-title":"Neurology."},{"key":"2023072317370281500_bib29","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1126\/science.aad8305","article-title":"Structure and membrane remodeling activity of ESCRT-III helical polymers","volume":"350","author":"McCullough","year":"2015","journal-title":"Science."},{"key":"2023072317370281500_bib30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2017.06.003","article-title":"DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy","volume":"42","author":"Nguyen","year":"2017","journal-title":"Dev. Cell."},{"key":"2023072317370281500_bib31","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1177\/21.11.963","article-title":"Microperoxisomes","volume":"21","author":"Novikoff","year":"1973","journal-title":"J. Histochem. Cytochem."},{"key":"2023072317370281500_bib32","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1083\/jcb.87.1.180","article-title":"Organelle relationships in cultured 3T3-L1 preadipocytes","volume":"87","author":"Novikoff","year":"1980","journal-title":"J. Cell Biol."},{"key":"2023072317370281500_bib33","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1177\/21.6.540","article-title":"Studies on microperoxisomes. 3. Observations on human and rat hepatocytes","volume":"21","author":"Novikoff","year":"1973","journal-title":"J. Histochem. Cytochem."},{"key":"2023072317370281500_bib34","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/j.1471-4159.2008.05414.x","article-title":"Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule","volume":"106","author":"Pantakani","year":"2008","journal-title":"J. Neurochem."},{"key":"2023072317370281500_bib35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005149","article-title":"Spastin binds to lipid droplets and affects lipid metabolism","volume":"11","author":"Papadopoulos","year":"2015","journal-title":"PLoS Genet."},{"key":"2023072317370281500_bib36","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1172\/JCI40979","article-title":"Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network","volume":"120","author":"Park","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2023072317370281500_bib37","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1016\/j.bbamcr.2006.08.034","article-title":"Peroxisomal beta-oxidation--a metabolic pathway with multiple functions","volume":"1763","author":"Poirier","year":"2006","journal-title":"Biochim. Biophys. Acta."},{"key":"2023072317370281500_bib38","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1083\/jcb.201311051","article-title":"Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites","volume":"204","author":"Pol","year":"2014","journal-title":"J. Cell Biol."},{"key":"2023072317370281500_bib39","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s13238-011-1061-y","article-title":"Interactomic study on interaction between lipid droplets and mitochondria","volume":"2","author":"Pu","year":"2011","journal-title":"Protein Cell."},{"key":"2023072317370281500_bib40","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.ajhg.2007.12.018","article-title":"Neuropathy target esterase gene mutations cause motor neuron disease","volume":"82","author":"Rainier","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"2023072317370281500_bib41","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.devcel.2015.01.029","article-title":"Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics","volume":"32","author":"Rambold","year":"2015","journal-title":"Dev. Cell."},{"key":"2023072317370281500_bib42","first-page":"85","article-title":"Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels","volume":"103","author":"Ramos","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"2023072317370281500_bib43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/hmg\/ddi003","article-title":"The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B","volume":"14","author":"Reid","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"2023072317370281500_bib44","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1091\/mbc.e09-10-0879","article-title":"SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis","volume":"21","author":"Renvois\u00e9","year":"2010","journal-title":"Mol. Biol. Cell."},{"key":"2023072317370281500_bib45","first-page":"5111","article-title":"Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation","volume":"25","author":"Renvois\u00e9","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"2023072317370281500_bib46","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nature06482","article-title":"Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin","volume":"451","author":"Roll-Mecak","year":"2008","journal-title":"Nature."},{"key":"2023072317370281500_bib47","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1001\/archneur.1972.00490170090014","article-title":"Schilder\u2019s disease. Sex-linked recessive transmission with specific adrenal changes","volume":"27","author":"Schaumburg","year":"1972","journal-title":"Arch. Neurol."},{"key":"2023072317370281500_bib48","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1177\/002215540104901110","article-title":"Tubulo-reticular clusters of peroxisomes in living COS-7 cells: dynamic behavior and association with lipid droplets","volume":"49","author":"Schrader","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"2023072317370281500_bib49","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.bbalip.2017.06.005","article-title":"A different kind of love - lipid droplet contact sites","volume":"1862","author":"Schuldiner","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids."},{"key":"2023072317370281500_bib50","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1136\/jnnp.2003.022970","article-title":"X-linked adrenoleukodystrophy presenting as autosomal dominant pure hereditary spastic paraparesis","volume":"75","author":"Shaw-Smith","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"2023072317370281500_bib51","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.ajhg.2012.11.001","article-title":"Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia","volume":"91","author":"Tesson","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"2023072317370281500_bib52","doi-asserted-by":"publisher","first-page":"4158","DOI":"10.1073\/pnas.1403322112","article-title":"Peroxisome extensions deliver the Arabidopsis SDP1 lipase to oil bodies","volume":"112","author":"Thazar-Poulot","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072317370281500_bib53","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.bbalip.2009.10.006","article-title":"Lipid homeostasis, lipotoxicity and the metabolic syndrome","volume":"1801","author":"Unger","year":"2010","journal-title":"Biochim. Biophys. Acta."},{"key":"2023072317370281500_bib54","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/cvr\/24.2.144","article-title":"Cumene hydroperoxide, an agent inducing lipid peroxidation, and 4-hydroxy-2,3-nonenal, a peroxidation product, cause coronary vasodilatation in perfused rat hearts by a cyclic nucleotide independent mechanism","volume":"24","author":"van der Kraaij","year":"1990","journal-title":"Cardiovasc. Res."},{"key":"2023072317370281500_bib55","doi-asserted-by":"publisher","first-page":"27004","DOI":"10.1038\/srep27004","article-title":"Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia","volume":"6","author":"Wali","year":"2016","journal-title":"Sci. Rep."},{"key":"2023072317370281500_bib56","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1146\/annurev-cellbio-100616-060608","article-title":"Lipid Droplet Biogenesis","volume":"33","author":"Walther","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2023072317370281500_bib57","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-94-007-6889-5_2","article-title":"Peroxisomes in human health and disease: metabolic pathways, metabolite transport, interplay with other organelles and signal transduction","volume":"69","author":"Wanders","year":"2013","journal-title":"Subcell. Biochem."},{"key":"2023072317370281500_bib58","doi-asserted-by":"publisher","first-page":"R470","DOI":"10.1016\/j.cub.2015.04.004","article-title":"Expanding roles for lipid droplets","volume":"25","author":"Welte","year":"2015","journal-title":"Curr. Biol."},{"key":"2023072317370281500_bib59","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1083\/jcb.200610072","article-title":"Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing","volume":"176","author":"White","year":"2007","journal-title":"J. Cell Biol."},{"key":"2023072317370281500_bib60","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.devcel.2013.01.013","article-title":"Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets","volume":"24","author":"Wilfling","year":"2013","journal-title":"Dev. Cell"},{"key":"2023072317370281500_bib61","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41580-018-0071-5","article-title":"Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes","volume":"20","author":"Wong","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023072317370281500_bib62","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25916","article-title":"Enhanced FIB-SEM systems for large-volume 3D imaging","volume":"6","author":"Xu","year":"2017","journal-title":"eLife."},{"key":"2023072317370281500_bib63","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1038\/nsmb.1512","article-title":"Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B","volume":"15","author":"Yang","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2023072317370281500_bib64","doi-asserted-by":"publisher","first-page":"16724","DOI":"10.1074\/jbc.RA118.004049","article-title":"Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways","volume":"293","author":"Young","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2023072317370281500_bib65","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ejmg.2013.04.008","article-title":"Exome sequencing released a case of X-linked adrenoleukodystrophy mimicking recessive hereditary spastic paraplegia","volume":"56","author":"Zhan","year":"2013","journal-title":"Eur. J. Med. Genet."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/218\/8\/2583\/1615258\/jcb_201902061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/218\/8\/2583\/1615258\/jcb_201902061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T13:40:02Z","timestamp":1690119602000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/218\/8\/2583\/120780\/Spastin-tethers-lipid-droplets-to-peroxisomes-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,21]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8,5]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201902061","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/544023","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.736033076.793561904","asserted-by":"object"}]},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,21]]}}}