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Their assembly and disassembly are tightly coupled to cell cycle progression. Here, we present data identifying KIF14 as a regulator of cilia formation and Hedgehog (HH) signaling. We show that RNAi depletion of KIF14 specifically leads to defects in ciliogenesis and basal body (BB) biogenesis, as its absence hampers the efficiency of primary cilium formation and the dynamics of primary cilium elongation, and disrupts the localization of the distal appendage proteins SCLT1 and FBF1 and components of the IFT-B complex. We identify deregulated Aurora A activity as a mechanism contributing to the primary cilium and BB formation defects seen after KIF14 depletion. In addition, we show that primary cilia in KIF14-depleted cells are defective in response to HH pathway activation, independently of the effects of Aurora A. In sum, our data point to KIF14 as a critical node connecting cell cycle machinery, effective ciliogenesis, and HH signaling.<\/jats:p>","DOI":"10.1083\/jcb.201904107","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T13:28:49Z","timestamp":1588166929000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling"],"prefix":"10.1083","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1530-4862","authenticated-orcid":true,"given":"Petra","family":"Pejskova","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Masaryk University, Faculty of Medicine, Brno, Czech Republic 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline Louise","family":"Reilly","sequence":"additional","affiliation":[{"name":"Laboratory of Hereditary Kidney Diseases, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR 1163, Paris University, Imagine Institute, Paris, France 2"},{"name":"Paris Diderot University, Paris, France 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Bino","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Masaryk University, Faculty of Medicine, Brno, Czech Republic 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2188-332X","authenticated-orcid":true,"given":"Ondrej","family":"Bernatik","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Masaryk University, Faculty of Medicine, Brno, Czech Republic 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Dolanska","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Masaryk University, Faculty of Medicine, Brno, Czech Republic 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjani Sri","family":"Ganji","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, Brno, Czech Republic 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbynek","family":"Zdrahal","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, Brno, Czech Republic 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0188-8016","authenticated-orcid":true,"given":"Alexandre","family":"Benmerah","sequence":"additional","affiliation":[{"name":"Laboratory of Hereditary Kidney Diseases, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR 1163, Paris University, Imagine Institute, Paris, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-8589","authenticated-orcid":true,"given":"Lukas","family":"Cajanek","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Masaryk University, Faculty of Medicine, Brno, Czech Republic 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"2023072715300498700_bib1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1750-1172-7-27","article-title":"A mutation in KIF7 is responsible for the autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia and distinctive facial appearance","volume":"7","author":"Ali","year":"2012","journal-title":"Orphanet J. 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