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A previous genome-wide screen revealed that depletion of 14 RNA splicing factors leads to a specific defect in centriole duplication, but the cause of this deficit remains unknown. Here, we identified an additional pre-mRNA splicing factor, WBP11, as a novel protein required for centriole duplication. Loss of WBP11 results in the retention of \u223c200 introns, including multiple introns in TUBGCP6, a central component of the \u03b3-TuRC. WBP11 depletion causes centriole duplication defects, in part by causing a rapid decline in the level of TUBGCP6. Several additional splicing factors that are required for centriole duplication interact with WBP11 and are required for TUBGCP6 expression. These findings provide insight into how the loss of a subset of splicing factors leads to a failure of centriole duplication. This may have clinical implications because mutations in some spliceosome proteins cause microcephaly and\/or growth retardation, phenotypes that are strongly linked to centriole defects.<\/jats:p>","DOI":"10.1083\/jcb.201904203","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T13:14:20Z","timestamp":1577193260000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication"],"prefix":"10.1083","volume":"219","author":[{"given":"Elizabeth M.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip M.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Clutario","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-0011","authenticated-orcid":true,"given":"Katelyn B.","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-5051","authenticated-orcid":true,"given":"Scott A.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 2"},{"name":"Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 3"},{"name":"Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-6367","authenticated-orcid":true,"given":"Andrew J.","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2019,12,24]]},"reference":[{"key":"2023072202554871500_bib1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.molcel.2011.03.014","article-title":"SON controls cell-cycle progression by coordinated regulation of RNA splicing","volume":"42","author":"Ahn","year":"2011","journal-title":"Mol. 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