{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:01:48Z","timestamp":1790812908881,"version":"4.1.0"},"reference-count":80,"publisher":"Rockefeller University Press","issue":"2","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.rupress.org\/terms\/"},{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":209,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-13-JSV2-0003-01"],"award-info":[{"award-number":["ANR-13-JSV2-0003-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["RTI2018-099718"],"award-info":[{"award-number":["RTI2018-099718"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["EL2014.LNCC\/CAR"],"award-info":[{"award-number":["EL2014.LNCC\/CAR"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Maria de Maeztu"},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"ARC Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"Marie-Sklodowska-Curie","doi-asserted-by":"publisher","award":["ANR-10-INBS-08-01"],"award-info":[{"award-number":["ANR-10-INBS-08-01"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"Marie-Sklodowska-Curie","doi-asserted-by":"publisher","award":["ANR-10-LABX-49-01"],"award-info":[{"award-number":["ANR-10-LABX-49-01"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Economy, Industry, and Competitiveness","award":["RTI2018-099718"],"award-info":[{"award-number":["RTI2018-099718"]}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:p>Invadosomes support cell invasion by coupling both acto-adhesive and extracellular matrix degradative functions, which are apparently antagonistic. \u03b21-integrin dynamics regulate this coupling, but the actual sensing mechanism and effectors involved have not yet been elucidated. Using genetic and reverse genetic approaches combined with biochemical and imaging techniques, we now show that the calcium channel TRPV4 colocalizes with \u03b21-integrins at the invadosome periphery and regulates its activation and the coupling of acto-adhesive and degradative functions. TRPV4-mediated regulation of podosome function depends on its ability to sense reactive oxygen species (ROS) in invadosomes\u2019 microenvironment and involves activation of the ROS\/calcium-sensitive kinase Ask1 and binding of the motor MYO1C. Furthermore, disease-associated TRPV4 gain-of-function mutations that modulate ECM degradation are also implicated in the ROS response, which provides new perspectives in our understanding of the pathophysiology of TRPV4 channelopathies.<\/jats:p>","DOI":"10.1083\/jcb.201910079","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T02:22:22Z","timestamp":1605320542000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Cross-talk between the calcium channel TRPV4 and reactive oxygen species interlocks adhesive and degradative functions of invadosomes"],"prefix":"10.1083","volume":"220","author":[{"given":"Sanela","family":"Vellino","sequence":"first","affiliation":[{"name":"Dynamique des syst\u00e8mes d'adh\u00e9rence, Institut for Advanced Biosciences, Centre de Recherche University Grenoble Alpes\/INSERM U1209\/Centre National de la Recherche Scientifique Unit\u00e9 mixte de recherche 5309, La Tronche, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Oddou","sequence":"additional","affiliation":[{"name":"Dynamique des syst\u00e8mes d'adh\u00e9rence, Institut for Advanced Biosciences, Centre de Recherche University Grenoble Alpes\/INSERM U1209\/Centre National de la Recherche Scientifique Unit\u00e9 mixte de recherche 5309, La Tronche, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Rivier","sequence":"additional","affiliation":[{"name":"Dynamique des syst\u00e8mes d'adh\u00e9rence, Institut for Advanced Biosciences, Centre de Recherche University Grenoble Alpes\/INSERM U1209\/Centre National de la Recherche Scientifique Unit\u00e9 mixte de recherche 5309, La Tronche, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-4292","authenticated-orcid":true,"given":"Cyril","family":"Boyault","sequence":"additional","affiliation":[{"name":"Dynamique des syst\u00e8mes d'adh\u00e9rence, Institut for Advanced Biosciences, Centre de Recherche University Grenoble Alpes\/INSERM U1209\/Centre National de la Recherche Scientifique Unit\u00e9 mixte de recherche 5309, La Tronche, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwige","family":"Hiriart-Bryant","sequence":"additional","affiliation":[{"name":"Dynamique des syst\u00e8mes d'adh\u00e9rence, Institut for Advanced Biosciences, Centre de Recherche University Grenoble Alpes\/INSERM U1209\/Centre National de la Recherche Scientifique Unit\u00e9 mixte de recherche 5309, La Tronche, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-4364","authenticated-orcid":true,"given":"Alexandra","family":"Kraut","sequence":"additional","affiliation":[{"name":"Laboratoire EDyP, Institute of Biosciences and Biotechnologies of Grenoble-Biologie \u00e0 Grande Echelle, Commissariat \u00e0 l'\u00c9nergie Atomique Grenoble, Grenoble, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Martin","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Technische Universit\u00e4t Dresden, Dresden, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3896-6196","authenticated-orcid":true,"given":"Yohann","family":"Coute","sequence":"additional","affiliation":[{"name":"Laboratoire EDyP, Institute of Biosciences and Biotechnologies of Grenoble-Biologie \u00e0 Grande Echelle, Commissariat \u00e0 l'\u00c9nergie Atomique Grenoble, Grenoble, France 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9631-5239","authenticated-orcid":true,"given":"Hans-Joachim","family":"Kn\u00f6lker","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Technische Universit\u00e4t Dresden, Dresden, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6961-3361","authenticated-orcid":true,"given":"Miguel A.","family":"Valverde","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-4150","authenticated-orcid":true,"given":"Corinne","family":"Albig\u00e8s-Rizo","sequence":"additional","affiliation":[{"name":"Dynamique des syst\u00e8mes d'adh\u00e9rence, Institut for Advanced Biosciences, Centre de Recherche University Grenoble Alpes\/INSERM U1209\/Centre National de la Recherche Scientifique Unit\u00e9 mixte de recherche 5309, La Tronche, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-3700","authenticated-orcid":true,"given":"Olivier","family":"Destaing","sequence":"additional","affiliation":[{"name":"Dynamique des syst\u00e8mes d'adh\u00e9rence, Institut for Advanced Biosciences, Centre de Recherche University Grenoble Alpes\/INSERM U1209\/Centre National de la Recherche Scientifique Unit\u00e9 mixte de recherche 5309, La Tronche, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"2025042816345335600_bib1","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.3390\/ijms20143576","article-title":"Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases","volume":"20","author":"Agidigbi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2025042816345335600_bib2","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1523\/JNEUROSCI.4497-07.2008","article-title":"Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia","volume":"28","author":"Alessandri-Haber","year":"2008","journal-title":"J. Neurosci."},{"key":"2025042816345335600_bib3","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1515\/CCLM.2008.302","article-title":"Oxidative stress, free radicals and bone remodeling","volume":"46","author":"Banfi","year":"2008","journal-title":"Clin. Chem. Lab. Med."},{"key":"2025042816345335600_bib4","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1091\/mbc.e12-12-0908","article-title":"\u03b21 integrin regulates Arg to promote invadopodial maturation and matrix degradation","volume":"24","author":"Beaty","year":"2013","journal-title":"Mol. Biol. Cell."},{"key":"2025042816345335600_bib5","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1021\/cb300625g","article-title":"HyPer-3: a genetically encoded H(2)O(2) probe with improved performance for ratiometric and fluorescence lifetime imaging","volume":"8","author":"Bilan","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"2025042816345335600_bib6","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1002\/jcp.24032","article-title":"Annexin A1: novel roles in skeletal muscle biology","volume":"227","author":"Bizzarro","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"2025042816345335600_bib7","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.ejcb.2012.06.003","article-title":"Spatiotemporal regulation of Src and its substrates at invadosomes","volume":"91","author":"Boateng","year":"2012","journal-title":"Eur. J. Cell Biol."},{"key":"2025042816345335600_bib8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.cellsig.2012.09.026","article-title":"Functional roles for myosin 1c in cellular signaling pathways","volume":"25","author":"Bond","year":"2013","journal-title":"Cell. Signal."},{"key":"2025042816345335600_bib9","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1242\/bio.20121867","article-title":"Adhesion rings surround invadopodia and promote maturation","volume":"1","author":"Branch","year":"2012","journal-title":"Biol. Open."},{"key":"2025042816345335600_bib10","doi-asserted-by":"publisher","first-page":"H634","DOI":"10.1152\/ajpheart.00717.2011","article-title":"Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca 2+ entry and mitochondrial ROS signaling","volume":"302","author":"Bubolz","year":"2011","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"2025042816345335600_bib11","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1091\/mbc.e08-09-0949","article-title":"The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation","volume":"20","author":"Buschman","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"2025042816345335600_bib12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1083\/jcb.200211118","article-title":"Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion","volume":"161","author":"Chiarugi","year":"2003","journal-title":"J. Cell Biol."},{"key":"2025042816345335600_bib13","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/cbic.201700693","article-title":"Pentachloropseudilin Inhibits Transforming Growth Factor-\u03b2 (TGF-\u03b2) Activity by Accelerating Cell-Surface Type\u2005II TGF-\u03b2 Receptor Turnover in Target Cells","volume":"19","author":"Chung","year":"2018","journal-title":"ChemBioChem."},{"key":"2025042816345335600_bib14","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/sj.emboj.7600931","article-title":"TRPM7, a novel regulator of actomyosin contractility and cell adhesion","volume":"25","author":"Clark","year":"2006","journal-title":"EMBO J."},{"key":"2025042816345335600_bib15","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.freeradbiomed.2012.05.032","article-title":"Integrin \u03b17\u03b21 is a redox-regulated target of hydrogen peroxide in vascular smooth muscle cell adhesion","volume":"53","author":"de Rezende","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"2025042816345335600_bib16","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1091\/mbc.e02-07-0389","article-title":"Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein","volume":"14","author":"Destaing","year":"2003","journal-title":"Mol. Biol. Cell."},{"key":"2025042816345335600_bib17","doi-asserted-by":"publisher","first-page":"4108","DOI":"10.1091\/mbc.e10-07-0580","article-title":"\u03b21A integrin is a master regulator of invadosome organization and function","volume":"21","author":"Destaing","year":"2010","journal-title":"Mol. Biol. Cell."},{"key":"2025042816345335600_bib18","doi-asserted-by":"publisher","first-page":"ra53","DOI":"10.1126\/scisignal.2000368","article-title":"Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation","volume":"2","author":"Diaz","year":"2009","journal-title":"Sci. Signal."},{"key":"2025042816345335600_bib19","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.1083\/jcb.201704048","article-title":"Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation","volume":"216","author":"Donnelly","year":"2017","journal-title":"J. Cell Biol."},{"key":"2025042816345335600_bib20","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1038\/ncb1175","article-title":"Calpain-mediated proteolysis of talin regulates adhesion dynamics","volume":"6","author":"Franco","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"2025042816345335600_bib21","doi-asserted-by":"publisher","first-page":"31284","DOI":"10.1074\/jbc.C800184200","article-title":"IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site","volume":"283","author":"Garcia-Elias","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2025042816345335600_bib22","doi-asserted-by":"publisher","first-page":"9553","DOI":"10.1073\/pnas.1220231110","article-title":"Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli","volume":"110","author":"Garcia-Elias","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025042816345335600_bib23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/978-3-642-54215-2_12","article-title":"The TRPV4 channel","volume":"222","author":"Garcia-Elias","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"2025042816345335600_bib24","doi-asserted-by":"publisher","first-page":"ra54","DOI":"10.1126\/scisignal.2000370","article-title":"Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity","volume":"2","author":"Gianni","year":"2009","journal-title":"Sci. Signal."},{"key":"2025042816345335600_bib25","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.1091\/mbc.e10-08-0685","article-title":"c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells","volume":"21","author":"Gianni","year":"2010","journal-title":"Mol. Biol. Cell."},{"key":"2025042816345335600_bib26","doi-asserted-by":"publisher","first-page":"6391","DOI":"10.1128\/MCB.25.15.6391-6403.2005","article-title":"Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth","volume":"25","author":"Giannoni","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"2025042816345335600_bib27","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.freeradbiomed.2010.04.025","article-title":"Src redox regulation: again in the front line","volume":"49","author":"Giannoni","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"2025042816345335600_bib28","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1073\/pnas.1811095116","article-title":"TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension","volume":"116","author":"Gilchrist","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025042816345335600_bib29","doi-asserted-by":"publisher","first-page":"E2433","DOI":"10.1073\/pnas.1207811109","article-title":"Myosin IC generates power over a range of loads via a new tension-sensing mechanism","volume":"109","author":"Greenberg","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025042816345335600_bib30","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1111\/j.1742-4658.2008.06407.x","article-title":"Redox regulation of dimerization of the receptor protein-tyrosine phosphatases RPTPalpha, LAR, RPTPmu and CD45","volume":"275","author":"Groen","year":"2008","journal-title":"FEBS J."},{"key":"2025042816345335600_bib31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1478-811X-7-9","article-title":"The roles of ASK family proteins in stress responses and diseases","volume":"7","author":"Hattori","year":"2009","journal-title":"Cell Commun. Signal."},{"key":"2025042816345335600_bib32","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/978-3-319-05161-1_10","article-title":"Structural biology of TRP channels","volume":"223","author":"Hellmich","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"2025042816345335600_bib33","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3389\/fncel.2016.00232","article-title":"Enhanced Oxidative Stress Is Responsible for TRPV4-Induced Neurotoxicity","volume":"10","author":"Hong","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"2025042816345335600_bib34","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.str.2013.11.008","article-title":"Structural insight into the assembly of TRPV channels","volume":"22","author":"Huynh","year":"2014","journal-title":"Structure."},{"key":"2025042816345335600_bib35","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1038\/s41467-018-04865-7","article-title":"LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration","volume":"9","author":"Infante","year":"2018","journal-title":"Nat. Commun."},{"key":"2025042816345335600_bib36","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.bbrc.2004.12.002","article-title":"CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy","volume":"327","author":"Kashiwase","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025042816345335600_bib37","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.1242\/jcs.075200","article-title":"Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation","volume":"123","author":"Kelley","year":"2010","journal-title":"J. Cell Sci."},{"key":"2025042816345335600_bib38","doi-asserted-by":"publisher","first-page":"5070","DOI":"10.1073\/pnas.0806117106","article-title":"Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation","volume":"106","author":"Kemble","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025042816345335600_bib39","doi-asserted-by":"publisher","first-page":"G230","DOI":"10.1152\/ajpgi.00436.2009","article-title":"Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells","volume":"301","author":"Kishimoto","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2025042816345335600_bib40","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nrm3810","article-title":"The amyloid state and its association with protein misfolding diseases","volume":"15","author":"Knowles","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025042816345335600_bib41","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1124\/mol.113.088864","article-title":"Transnitrosylation directs TRPA1 selectivity in N-nitrosamine activators","volume":"85","author":"Kozai","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"2025042816345335600_bib42","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.1038\/ncomms6343","article-title":"Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes","volume":"5","author":"Labernadie","year":"2014","journal-title":"Nat. Commun."},{"key":"2025042816345335600_bib43","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1096\/fj.201500073R","article-title":"CIB1: a small protein with big ambitions","volume":"30","author":"Leisner","year":"2016","journal-title":"FASEB J."},{"key":"2025042816345335600_bib44","doi-asserted-by":"publisher","first-page":"9400","DOI":"10.1073\/pnas.1510602112","article-title":"A channelopathy mechanism revealed by direct calmodulin activation of TrpV4","volume":"112","author":"Loukin","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025042816345335600_bib45","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/NEN.0000000000000187","article-title":"Membrane proteome analysis of glioblastoma cell invasion","volume":"74","author":"Mallawaaratchy","year":"2015","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2025042816345335600_bib46","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/cm.21310","article-title":"Calcium-regulated import of myosin IC into the nucleus","volume":"73","author":"Maly","year":"2016","journal-title":"Cytoskeleton (Hoboken)."},{"key":"2025042816345335600_bib47","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6235641","article-title":"Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy","volume":"2016","author":"Marengo","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2025042816345335600_bib48","doi-asserted-by":"publisher","first-page":"8042","DOI":"10.1002\/anie.200903743","article-title":"Total synthesis of pentabromo- and pentachloropseudilin, and synthetic analogues--allosteric inhibitors of myosin ATPase","volume":"48","author":"Martin","year":"2009","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"2025042816345335600_bib49","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1002\/jbmr.1629","article-title":"Calcium\/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass","volume":"27","author":"Masuyama","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"2025042816345335600_bib50","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1039\/c0ib00034e","article-title":"Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface \u03b21 integrins","volume":"2","author":"Matthews","year":"2010","journal-title":"Integr. Biol."},{"key":"2025042816345335600_bib51","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/boc.201600041","article-title":"\u03b1v\u03b23 integrins negatively regulate cellular forces by phosphorylation of its distal NPXY site","volume":"109","author":"Milloud","year":"2017","journal-title":"Biol. Cell."},{"key":"2025042816345335600_bib52","author":"Moore","year":"2017"},{"key":"2025042816345335600_bib53","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1007\/s00424-014-1679-8","article-title":"TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells","volume":"467","author":"Mrkonji\u0107","year":"2015","journal-title":"Pflugers Arch."},{"key":"2025042816345335600_bib54","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ceca.2011.12.012","article-title":"Translocation of calcium-permeable TRPV2 channel to the podosome: Its role in the regulation of podosome assembly","volume":"51","author":"Nagasawa","year":"2012","journal-title":"Cell Calcium."},{"key":"2025042816345335600_bib55","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/84397","article-title":"A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein","volume":"19","author":"Nakai","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"2025042816345335600_bib56","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/embor.2012.219","article-title":"The puzzle of TRPV4 channelopathies","volume":"14","author":"Nilius","year":"2013","journal-title":"EMBO Rep."},{"key":"2025042816345335600_bib57","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jbior.2017.05.004","article-title":"The regulatory and signaling mechanisms of the ASK family","volume":"66","author":"Nishida","year":"2017","journal-title":"Adv. Biol. Regul."},{"key":"2025042816345335600_bib58","doi-asserted-by":"publisher","first-page":"4197","DOI":"10.1074\/jbc.M115.700278","article-title":"Functional and structural divergence in human TRPV1 channel subunits by oxidative cysteine modification","volume":"291","author":"Ogawa","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2025042816345335600_bib59","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1073\/pnas.1718177115","article-title":"Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses","volume":"115","author":"Pardo-Pastor","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025042816345335600_bib60","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/febs.14123","article-title":"Invadosomes are coming: new insights into function and disease relevance","volume":"285","author":"Paterson","year":"2018","journal-title":"FEBS J."},{"key":"2025042816345335600_bib61","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1083\/jcb.201510036","article-title":"Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes","volume":"213","author":"Petropoulos","year":"2016","journal-title":"J. Cell Biol."},{"key":"2025042816345335600_bib62","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1073\/pnas.1010396108","article-title":"Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel","volume":"108","author":"Poincloux","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2025042816345335600_bib63","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/jid.2013.365","article-title":"Somatic mutations in MAP3K5 attenuate its proapoptotic function in melanoma through increased binding to thioredoxin","volume":"134","author":"Prickett","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"2025042816345335600_bib64","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1083\/jcb.200709076","article-title":"The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA","volume":"181","author":"Sakurai-Yageta","year":"2008","journal-title":"J. Cell Biol."},{"key":"2025042816345335600_bib65","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1021\/acs.jproteome.6b00126","article-title":"Nuclear functions of nucleolin through global proteomics and interactomic approaches","volume":"15","author":"Salvetti","year":"2016","journal-title":"J. Proteome Res."},{"key":"2025042816345335600_bib66","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/embor.2013.49","article-title":"Mechanosensitivity and compositional dynamics of cell-matrix adhesions","volume":"14","author":"Schiller","year":"2013","journal-title":"EMBO Rep."},{"key":"2025042816345335600_bib80","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1016\/j.cub.2013.08.044","article-title":"Tks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells","volume":"23","author":"Sharma","year":"2013","journal-title":"Curr Biol"},{"key":"2025042816345335600_bib67","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/1742-2094-9-250","article-title":"Regulation of podosome formation, microglial migration and invasion by Ca(2+)-signaling molecules expressed in podosomes","volume":"9","author":"Siddiqui","year":"2012","journal-title":"J. Neuroinflammation."},{"key":"2025042816345335600_bib68","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.semcancer.2016.12.001","article-title":"Roles of pH and the Na+\/H+ exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?","volume":"43","author":"Stock","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"2025042816345335600_bib69","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1083\/jcb.201407082","article-title":"STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion","volume":"207","author":"Sun","year":"2014","journal-title":"J. Cell Biol."},{"key":"2025042816345335600_bib70","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1089\/ars.2006.1392","article-title":"Integrin-mediated cell adhesion and spreading engage different sources of reactive oxygen species","volume":"9","author":"Taddei","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"2025042816345335600_bib71","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nsmb725","article-title":"Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing","volume":"11","author":"Tang","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2025042816345335600_bib72","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/CIRCRESAHA.108.192930","article-title":"TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling","volume":"104","author":"Thodeti","year":"2009","journal-title":"Circ. Res."},{"key":"2025042816345335600_bib73","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1083\/jcb.200211061","article-title":"RPTP-\u03b1 acts as a transducer of mechanical force on alphav\/\u03b23-integrin-cytoskeleton linkages","volume":"161","author":"von Wichert","year":"2003","journal-title":"J. Cell Biol."},{"key":"2025042816345335600_bib74","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1152\/physrev.00016.2015","article-title":"TRPV4: Molecular Conductor of a Diverse Orchestra","volume":"96","author":"White","year":"2016","journal-title":"Physiol. Rev."},{"key":"2025042816345335600_bib75","doi-asserted-by":"publisher","first-page":"16227","DOI":"10.18632\/oncotarget.7583","article-title":"Mechanosensitive caveolin-1 activation-induced PI3K\/Akt\/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget."},{"key":"2025042816345335600_bib76","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.cmet.2008.09.011","article-title":"CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes","volume":"8","author":"Yip","year":"2008","journal-title":"Cell Metab."},{"key":"2025042816345335600_bib79","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.3390\/ijms20194960","article-title":"PIEZO1 and TRPV4, which Are Distinct Mechano-Sensors in the Osteoblastic MC3T3-E1 Cells, Modify Cell-Proliferation","volume":"20","author":"Yoneda","year":"2019","journal-title":"IJMS"},{"key":"2025042816345335600_bib77","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nature10632","article-title":"Lyn is a redox sensor that mediates leukocyte wound attraction in vivo","volume":"480","author":"Yoo","year":"2011","journal-title":"Nature."},{"key":"2025042816345335600_bib78","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1083\/jcb.201203154","article-title":"Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish","volume":"199","author":"Yoo","year":"2012","journal-title":"J. Cell Biol."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.201910079\/1818202\/jcb_201910079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.201910079\/1818202\/jcb_201910079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T16:34:59Z","timestamp":1745858099000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/220\/2\/e201910079\/211651\/Cross-talk-between-the-calcium-channel-TRPV4-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":80,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.201910079","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"article-number":"e201910079"}}