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Tricellulin and angulin family membrane proteins are known constituents of tTJs, but the molecular mechanism of tTJ formation remains elusive. Here, we investigated the roles of angulin-1 and tricellulin in tTJ formation in MDCK II cells by genome editing. Angulin-1\u2013deficient cells lost the plasma membrane contact at TCs with impaired epithelial barrier function. The C terminus of angulin-1 bound to the TJ scaffold protein ZO-1, and disruption of their interaction influenced the localization of claudins at TCs, but not the tricellular sealing. Strikingly, the plasma membrane contact at TCs was formed in tricellulin- or claudin-deficient cells. These findings demonstrate that angulin-1 is responsible for the plasma membrane seal at TCs independently of tricellulin and claudins.<\/jats:p>","DOI":"10.1083\/jcb.202005062","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T02:22:08Z","timestamp":1624328528000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Angulin-1 seals tricellular contacts independently of tricellulin and claudins"],"prefix":"10.1083","volume":"220","author":[{"given":"Taichi","family":"Sugawara","sequence":"first","affiliation":[{"name":"Division of Cell Structure, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki, Aichi, Japan 1"},{"name":"Department of Physiological Sciences, The Graduate University for Advanced Studies, SOKENDAI, Okazaki, Aichi, Japan 2"},{"name":"Department of Histology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-6204","authenticated-orcid":true,"given":"Kyoko","family":"Furuse","sequence":"additional","affiliation":[{"name":"Division of Cell Structure, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki, Aichi, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-6722","authenticated-orcid":true,"given":"Tetsuhisa","family":"Otani","sequence":"additional","affiliation":[{"name":"Division of Cell Structure, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki, Aichi, Japan 1"},{"name":"Department of Physiological Sciences, The Graduate University for Advanced Studies, SOKENDAI, Okazaki, Aichi, Japan 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Wakayama","sequence":"additional","affiliation":[{"name":"Department of Histology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2847-8156","authenticated-orcid":true,"given":"Mikio","family":"Furuse","sequence":"additional","affiliation":[{"name":"Division of Cell Structure, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki, Aichi, Japan 1"},{"name":"Department of Physiological Sciences, The Graduate University for Advanced Studies, SOKENDAI, Okazaki, Aichi, Japan 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"2023072317454683100_bib1","doi-asserted-by":"publisher","first-page":"4969","DOI":"10.1242\/jcs.00165","article-title":"Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells","volume":"115","author":"Amasheh","year":"2002","journal-title":"J. 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