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In migrating epithelial sheets, leader cells form lamellipodia to advance, and follower cells also form similar motile apparatus at cell\u2013cell boundaries, which are called cryptic lamellipodia (c-lamellipodia). Using adenocarcinoma-derived epithelial cells, we investigated how c-lamellipodia form and found that they sporadically grew from around E-cadherin\u2013based adherens junctions (AJs). WAVE and Arp2\/3 complexes were localized along the AJs, and silencing them not only interfered with c-lamellipodia formation but also prevented follower cells from trailing the leaders. Disruption of AJs by removing \u03b1E-catenin resulted in uncontrolled c-lamellipodia growth, and this was brought about by myosin II activation and the resultant contraction of AJ-associated actomyosin cables. Additional observations indicated that c-lamellipodia tended to grow at mechanically weak sites of the junction. We conclude that AJs not only tie cells together but also support c-lamellipodia formation by recruiting actin regulators, enabling epithelial cells to undergo ordered collective migration.<\/jats:p>","DOI":"10.1083\/jcb.202006196","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T02:22:29Z","timestamp":1595902949000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Adherens junction regulates cryptic lamellipodia formation for epithelial cell migration"],"prefix":"10.1083","volume":"219","author":[{"given":"Masayuki","family":"Ozawa","sequence":"first","affiliation":[{"name":"Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Hiver","sequence":"additional","affiliation":[{"name":"Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Laboratory for Physical Biology, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-9998","authenticated-orcid":true,"given":"Tatsuo","family":"Shibata","sequence":"additional","affiliation":[{"name":"Laboratory for Physical Biology, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srigokul","family":"Upadhyayula","sequence":"additional","affiliation":[{"name":"Advanced Bioimaging Center, Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3513-9072","authenticated-orcid":true,"given":"Yuko","family":"Mimori-Kiyosue","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular and Cellular Dynamics, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-3378","authenticated-orcid":true,"given":"Masatoshi","family":"Takeichi","sequence":"additional","affiliation":[{"name":"Laboratory for Cell Adhesion and Tissue Patterning, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"2023072813101643000_bib1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ceb.2004.01.005","article-title":"Setting up a selective barrier at the apical junction complex","volume":"16","author":"Anderson","year":"2004","journal-title":"Curr. 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