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Here, we show that WDR62 regulates spindle dynamics by recruiting katanin to the spindle pole and further reveal a TPX2\u2013Aurora A\u2013WDR62\u2013katanin axis in cells. By combining cellular and in vitro experiments, we demonstrate that WDR62 shows preference for curved segments of dynamic GDP-MTs, as well as GMPCPP- and paclitaxel-stabilized MTs, suggesting that it recognizes extended MT lattice. Consistent with this property, WDR62 alone is inefficient in recruiting katanin to GDP-MTs, while WDR62 complexed with TPX2\/Aurora A can potently promote katanin-mediated severing of GDP-MTs in vitro. In addition, the MT-binding affinity of WDR62 is autoinhibited through JNK phosphorylation-induced intramolecular interaction. We propose that WDR62 is an atypical MAP and functions as an adaptor protein between its recruiting factor TPX2\/Aurora A and the effector katanin to orchestrate the regulation of spindle dynamics.<\/jats:p>","DOI":"10.1083\/jcb.202007167","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T02:22:32Z","timestamp":1621390952000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["WDR62 regulates spindle dynamics as an adaptor protein between TPX2\/Aurora A and katanin"],"prefix":"10.1083","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4184-9505","authenticated-orcid":true,"given":"Junjie","family":"Huang","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China 1"},{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9025-8141","authenticated-orcid":true,"given":"Zhuobi","family":"Liang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China 1"},{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuirong","family":"Guan","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China 1"},{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Hua","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China 1"},{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6871-737X","authenticated-orcid":true,"given":"Kai","family":"Jiang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China 1"},{"name":"Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China 2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"2023072400413632700_bib1","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.cell.2014.03.053","article-title":"High-resolution microtubule structures reveal the structural transitions in \u03b1\u03b2-tubulin upon GTP hydrolysis","volume":"157","author":"Alushin","year":"2014","journal-title":"Cell."},{"key":"2023072400413632700_bib2","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1016\/j.cub.2014.08.039","article-title":"Doublecortin recognizes the longitudinal curvature of the microtubule end and lattice","volume":"24","author":"Bechstedt","year":"2014","journal-title":"Curr. 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