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However, through poorly understood mechanisms, BMs of adjacent tissue can also stably link to support organ structure and function. Using endogenous knock-in fluorescent proteins, conditional RNAi, optogenetics, and quantitative live imaging, we identified extracellular matrix proteins mediating a BM linkage (B-LINK) between the uterine utse and epidermal seam cell BMs in Caenorhabditis elegans that supports the uterus during egg-laying. We found that hemicentin is secreted by the utse and promotes fibulin-1 assembly to jointly initiate the B-LINK. During egg-laying, however, both proteins\u2019 levels decline and are not required for B-LINK maintenance. Instead, we discovered that hemicentin recruits ADAMTS9\/20, which facilitates the assembly of high levels of type IV collagen that sustains the B-LINK during the mechanically active egg-laying period. This work reveals mechanisms underlying BM\u2013BM linkage maturation and identifies a crucial function for hemicentin and fibulin-1 in initiating attachment and type IV collagen in strengthening this specialized form of tissue linkage.<\/jats:p>","DOI":"10.1083\/jcb.202112096","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T02:21:47Z","timestamp":1664245307000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Hemicentin-mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage"],"prefix":"10.1083","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4272-5520","authenticated-orcid":true,"given":"Claire A.","family":"Gianakas","sequence":"first","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC 1"},{"name":"Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Keeley","sequence":"additional","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-4571","authenticated-orcid":true,"given":"William","family":"Ramos-Lewis","sequence":"additional","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieop","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0465-0337","authenticated-orcid":true,"given":"Ranjay","family":"Jayadev","sequence":"additional","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel W.","family":"Kenny","sequence":"additional","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyi","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-6917","authenticated-orcid":true,"given":"David R.","family":"Sherwood","sequence":"additional","affiliation":[{"name":"Department of Biology, Duke University, Durham, NC 1"},{"name":"Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"2022102513130627700_bib1","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1083\/jcb.100.6.1988","article-title":"Origin of the glomerular basement membrane visualized after in vivo labeling of laminin in newborn rat kidneys","volume":"100","author":"Abrahamson","year":"1985","journal-title":"J. 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