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The physical formation of NE buds is dependent on the Wiskott\u2013Aldrich Syndrome protein, Wash, its regulatory complex (SHRC), and Arp2\/3, and requires Wash\u2019s actin nucleation activity. However, the machinery governing cargo recruitment and organization within the NE bud remains unknown. Here, we identify Pavarotti (Pav) and Tumbleweed (Tum) as new molecular components of NE budding. Pav and Tum interact directly with Wash and define a second nuclear Wash-containing complex required for NE budding. Interestingly, we find that the actin-bundling activity of Pav is required, suggesting a structural role in the physical and\/or organizational aspects of NE buds. Thus, Pav and Tum are providing exciting new entry points into the physical machineries of this alternative nuclear export pathway for large cargos during cell differentiation and development.<\/jats:p>","DOI":"10.1083\/jcb.202211074","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T02:21:22Z","timestamp":1682562082000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding"],"prefix":"10.1083","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9432-6359","authenticated-orcid":true,"given":"Kerri A.","family":"Davidson","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007ps6h72","id-type":"ROR","asserted-by":"publisher"}],"name":"Fred Hutchinson Cancer Center 1 Basic Sciences Division, , Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-3176","authenticated-orcid":true,"given":"Mitsutoshi","family":"Nakamura","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007ps6h72","id-type":"ROR","asserted-by":"publisher"}],"name":"Fred Hutchinson Cancer Center 1 Basic Sciences Division, , Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4454-6043","authenticated-orcid":true,"given":"Jeffrey M.","family":"Verboon","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007ps6h72","id-type":"ROR","asserted-by":"publisher"}],"name":"Fred Hutchinson Cancer Center 1 Basic Sciences Division, , Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-9930","authenticated-orcid":true,"given":"Susan M.","family":"Parkhurst","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/007ps6h72","id-type":"ROR","asserted-by":"publisher"}],"name":"Fred Hutchinson Cancer Center 1 Basic Sciences Division, , Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"2023051016245355600_bib1","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1101\/gad.12.10.1483","article-title":"Pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis","volume":"12","author":"Adams","year":"1998","journal-title":"Genes Dev."},{"key":"2023051016245355600_bib2","doi-asserted-by":"publisher","first-page":"9150","DOI":"10.1128\/JVI.02530-14","article-title":"The great (nuclear) escape: New insights into the role of the nuclear egress complex of herpesviruses","volume":"89","author":"Bigalke","year":"2015","journal-title":"J. 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