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The spindle assembly checkpoint (SAC) has been viewed as the sole surveillance mechanism that prevents chromosome segregation errors during mitosis and meiosis. However, different types of chromosome segregation errors stemming from incorrect kinetochore\u2013microtubule attachments satisfy the SAC and are more frequent than previously anticipated. Remarkably, recent works have unveiled that most of these errors are corrected during anaphase and only rarely result in aneuploidy or formation of micronuclei. Here, we discuss recent progress in our understanding of the origin and fate of chromosome segregation errors that satisfy the SAC and shed light on the surveillance, correction, and clearance mechanisms that prevent their transmission, to preserve genomic stability.<\/jats:p>","DOI":"10.1083\/jcb.202301106","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T02:21:03Z","timestamp":1679710863000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Double-checking chromosome segregation"],"prefix":"10.1083","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-9997","authenticated-orcid":true,"given":"Helder","family":"Maiato","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04wjk1035","id-type":"ROR","asserted-by":"publisher"}],"name":"Chromosome Instability & Dynamics Group, i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto 1 , Porto, Portugal"},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto 2 , Porto, Portugal"},{"name":"Cell Division Group, Faculdade de Medicina, Universidade do Porto 3 Department of Biomedicine, , Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-3072","authenticated-orcid":true,"given":"S\u00f3nia","family":"Silva","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04wjk1035","id-type":"ROR","asserted-by":"publisher"}],"name":"Chromosome Instability & Dynamics Group, i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto 1 , Porto, Portugal"},{"id":[{"id":"https:\/\/ror.org\/043pwc612","id-type":"ROR","asserted-by":"publisher"}],"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto 2 , Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"2023040513305140700_","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1016\/j.cub.2020.04.081","article-title":"MKLP2 is a motile kinesin that transports the chromosomal passenger complex during anaphase","volume":"30","author":"Adriaans","year":"2020","journal-title":"Curr. 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