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While intercellular junctions are known to be important for the mechanical resistance of epithelia, the roles of tight junctions (TJs) remain to be established. We previously demonstrated that epithelial cells devoid of the TJ membrane proteins claudins and JAM-A completely lack TJs and exhibit focal breakages of their apical junctions. Here, we demonstrate that apical junctions fracture when claudin\/JAM-A\u2013deficient cells undergo spontaneous cell stretching. The junction fracture was accompanied by actin disorganization, and actin polymerization was required for apical junction integrity in the claudin\/JAM-A\u2013deficient cells. Further deletion of CAR resulted in the disruption of ZO-1 molecule ordering at cell junctions, accompanied by severe defects in apical junction integrity. 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Growth Differ."},{"key":"2024032213461648000_bib62","doi-asserted-by":"publisher","first-page":"5003","DOI":"10.1074\/jbc.M109.043760","article-title":"Involvement of the interaction of afadin with ZO-1 in the formation of tight junctions in Madin-Darby canine kidney cells","volume":"285","author":"Ooshio","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2024032213461648000_bib63","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.tcb.2020.08.004","article-title":"Tight junction structure and function revisited","volume":"30","author":"Otani","year":"2020","journal-title":"Trends Cell Biol."},{"key":"2024032213461648000_bib64","doi-asserted-by":"publisher","first-page":"3372","DOI":"10.1083\/jcb.201812157","article-title":"Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity","volume":"218","author":"Otani","year":"2019","journal-title":"J. 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