{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:00:58Z","timestamp":1791838858413,"version":"4.3.4"},"reference-count":307,"publisher":"Rockefeller University Press","issue":"2","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/rupress.org\/pages\/terms102024\/"}],"funder":[{"DOI":"10.13039\/501100004727","name":"Vlaams Instituut voor Biotechnologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1282123N"],"award-info":[{"award-number":["1282123N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011878","name":"Flemish Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson\u2019s","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SAO-FRA"},{"DOI":"10.13039\/100016608","name":"Rainwater Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer\u2019s Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:p>Synaptic dysfunction is one of the earliest cellular defects observed in Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD), occurring before widespread protein aggregation, neuronal loss, and cognitive decline. While the field has focused on the aggregation of Tau and \u03b1-Synuclein (\u03b1-Syn), emerging evidence suggests that these proteins may drive presynaptic pathology even before their aggregation. Therefore, understanding the mechanisms by which Tau and \u03b1-Syn affect presynaptic terminals offers an opportunity for developing innovative therapeutics aimed at preserving synapses and potentially halting neurodegeneration. This review focuses on the molecular defects that converge on presynaptic dysfunction caused by Tau and \u03b1-Syn. Both proteins have physiological roles in synapses. However, during disease, they acquire abnormal functions due to aberrant interactions and mislocalization. We provide an overview of current research on different essential presynaptic pathways influenced by Tau and \u03b1-Syn. Finally, we highlight promising therapeutic targets aimed at maintaining synaptic function in both tauopathies and synucleinopathies.<\/jats:p>","DOI":"10.1083\/jcb.202409104","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T02:21:30Z","timestamp":1733883690000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Synaptic sabotage: How Tau and \u03b1-Synuclein undermine synaptic health"],"prefix":"10.1083","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-2079","authenticated-orcid":true,"given":"Valerie","family":"Uytterhoeven","sequence":"first","affiliation":[{"name":"Vlaams Instituut voor Biotechnologie Center for Brain and Disease Research 1 , Leuven,","place":["Belgium"]},{"id":[{"id":"https:\/\/ror.org\/05f950310","id-type":"ROR","asserted-by":"publisher"}],"name":"Leuven Brain Institute, KU Leuven 2 Department of Neurosciences, , Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5073-5393","authenticated-orcid":true,"given":"Patrik","family":"Verstreken","sequence":"additional","affiliation":[{"name":"Vlaams Instituut voor Biotechnologie Center for Brain and Disease Research 1 , Leuven,","place":["Belgium"]},{"id":[{"id":"https:\/\/ror.org\/05f950310","id-type":"ROR","asserted-by":"publisher"}],"name":"Leuven Brain Institute, KU Leuven 2 Department of Neurosciences, , Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2069-6469","authenticated-orcid":true,"given":"Eliana","family":"Nachman","sequence":"additional","affiliation":[{"name":"Vlaams Instituut voor Biotechnologie Center for Brain and Disease Research 1 , Leuven,","place":["Belgium"]},{"id":[{"id":"https:\/\/ror.org\/05f950310","id-type":"ROR","asserted-by":"publisher"}],"name":"Leuven Brain Institute, KU Leuven 2 Department of Neurosciences, , Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"2024122414085603000_bib1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0896-6273(00)80886-7","article-title":"Mice lacking \u03b1-synuclein display functional deficits in the nigrostriatal dopamine system","volume":"25","author":"Abeliovich","year":"2000","journal-title":"Neuron"},{"key":"2024122414085603000_bib2","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1038\/s41556-024-01451-6","article-title":"VAMP2 regulates phase separation of \u03b1-synuclein","volume":"26","author":"Agarwal","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"2024122414085603000_bib3","doi-asserted-by":"publisher","first-page":"106011","DOI":"10.1016\/j.nbd.2023.106011","article-title":"Liquid-liquid phase separation of protein tau: An emerging process in Alzheimer\u2019s disease pathogenesis","volume":"178","author":"Ainani","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"2024122414085603000_bib4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3390\/jmp3040021","article-title":"The roles of calcium ions in Parkinson\u2019s disease: Calcium channel inhibitors as a novel agents?","volume":"3","author":"Alam","year":"2022","journal-title":"J. Mol. Pathol."},{"key":"2024122414085603000_bib5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/ANNUREV-GENET-112618-043527","article-title":"Liquid-liquid phase separation in disease","volume":"53","author":"Alberti","year":"2019","journal-title":"Annu. Rev. Genet."},{"key":"2024122414085603000_bib6","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1242\/JCS.180737","article-title":"Ca2+ is a key factor in \u03b1-synuclein-induced neurotoxicity","volume":"129","author":"Angelova","year":"2016","journal-title":"J. Cell Sci."},{"key":"2024122414085603000_bib7","doi-asserted-by":"publisher","first-page":"7264","DOI":"10.1523\/JNEUROSCI.6194-10.2011","article-title":"Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family","volume":"31","author":"Anwar","year":"2011","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib8","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1242\/jcs.158196","article-title":"LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism","volume":"128","author":"Arranz","year":"2015","journal-title":"J. Cell Sci."},{"key":"2024122414085603000_bib9","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/J.NEURON.2023.02.001","article-title":"EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation","volume":"111","author":"Bademosi","year":"2023","journal-title":"Neuron"},{"key":"2024122414085603000_bib10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026609","article-title":"Tau enhances \u03b1-synuclein aggregation and toxicity in cellular models of synucleinopathy","volume":"6","author":"Badiola","year":"2011","journal-title":"PLoS One"},{"key":"2024122414085603000_bib11","doi-asserted-by":"publisher","first-page":"ar128","DOI":"10.1091\/mbc.E22-01-0018","article-title":"Tau differentially regulates the transport of early endosomes and lysosomes","volume":"33","author":"Balabanian","year":"2022","journal-title":"Mol. Biol. Cell"},{"key":"2024122414085603000_bib12","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/J.NEURON.2023.01.016","article-title":"Neurodegeneration cell per cell","volume":"111","author":"Balusu","year":"2023","journal-title":"Neuron"},{"key":"2024122414085603000_bib13","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3389\/fnagi.2019.00204","article-title":"Role of tau as a microtubule-associated protein: Structural and functional aspects","volume":"11","author":"Barbier","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"2024122414085603000_bib14","doi-asserted-by":"publisher","DOI":"10.1084\/JEM.20192193","article-title":"\u03b1-Synuclein modulates tau spreading in mouse brains","volume":"218","author":"Bassil","year":"2021","journal-title":"J. Exp. Med."},{"key":"2024122414085603000_bib15","doi-asserted-by":"publisher","first-page":"33855","DOI":"10.1074\/JBC.274.48.33855","article-title":"Degradation of alpha-synuclein by proteasome","volume":"274","author":"Bennett","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib16","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.3389\/fnins.2019.01399","article-title":"Alpha-synuclein physiology and pathology: A perspective on cellular structures and organelles","volume":"13","author":"Bernal-Conde","year":"2020","journal-title":"Front. Neurosci."},{"key":"2024122414085603000_bib17","doi-asserted-by":"publisher","first-page":"12265","DOI":"10.1074\/jbc.RA119.009124","article-title":"Tau isoform-specific stabilization of intermediate states during microtubule assembly and disassembly","volume":"294","author":"Best","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib18","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744617","article-title":"Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation","volume":"19","author":"Betzer","year":"2018","journal-title":"EMBO Rep."},{"key":"2024122414085603000_bib19","doi-asserted-by":"publisher","first-page":"102133","DOI":"10.1016\/J.CECA.2019.102133","article-title":"Presynaptic endoplasmic reticulum and neurotransmission","volume":"85","author":"Bezprozvanny","year":"2020","journal-title":"Cell Calcium"},{"key":"2024122414085603000_bib20","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.conb.2005.08.016","article-title":"Synaptic protein degradation by the ubiquitin proteasome system","volume":"15","author":"Bingol","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"2024122414085603000_bib21","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","article-title":"The genetic architecture of Parkinson\u2019s disease","volume":"19","author":"Blauwendraat","year":"2020","journal-title":"Lancet Neurol."},{"key":"2024122414085603000_bib22","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/jnc.15035","article-title":"Presynaptic dysfunction in neurodevelopmental disorders: Insights from the synaptic vesicle life cycle","volume":"157","author":"Bonnycastle","year":"2021","journal-title":"J. Neurochem."},{"key":"2024122414085603000_bib23","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1016\/J.CELL.2021.03.048","article-title":"Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome","volume":"184","author":"Bourdenx","year":"2021","journal-title":"Cell"},{"key":"2024122414085603000_bib24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/S00441-004-0956-9","article-title":"Stages in the development of Parkinson\u2019s disease-related pathology","volume":"318","author":"Braak","year":"2004","journal-title":"Cell Tissue Res."},{"key":"2024122414085603000_bib25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0306-4522(88)90013-9","article-title":"Both adult and juvenile tau microtubule-associated proteins are axon specific in the developing and adult rat cerebellum","volume":"25","author":"Brion","year":"1988","journal-title":"Neuroscience"},{"key":"2024122414085603000_bib26","doi-asserted-by":"publisher","first-page":"102150","DOI":"10.1016\/j.ceca.2019.102150","article-title":"Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death","volume":"86","author":"Britti","year":"2020","journal-title":"Cell Calcium"},{"key":"2024122414085603000_bib27","doi-asserted-by":"publisher","first-page":"891508","DOI":"10.3389\/fmolb.2022.891508","article-title":"\u03b1-Synuclein in the synaptic vesicle liquid phase: Active player or passive bystander?","volume":"9","author":"Brodin","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"2024122414085603000_bib28","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1126\/SCIENCE.1195227","article-title":"Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro","volume":"329","author":"Burr\u00e9","year":"2010","journal-title":"Science"},{"key":"2024122414085603000_bib29","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1091\/MBC.E14-02-0708","article-title":"Acute increase of \u03b1-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation","volume":"25","author":"Busch","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"2024122414085603000_bib30","doi-asserted-by":"publisher","first-page":"29542","DOI":"10.1074\/JBC.M115.691592","article-title":"Dopamine transporter activity is modulated by \u03b1-synuclein","volume":"290","author":"Butler","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib31","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1038\/s41467-021-22501-9","article-title":"Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice","volume":"12","author":"Caballero","year":"2021","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib32","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12692","article-title":"Interplay of pathogenic forms of human tau with different autophagic pathways","volume":"17","author":"Caballero","year":"2018","journal-title":"Aging Cell"},{"key":"2024122414085603000_bib33","doi-asserted-by":"publisher","first-page":"8797","DOI":"10.1523\/JNEUROSCI.22-20-08797.2002","article-title":"Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein","volume":"22","author":"Cabin","year":"2002","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib34","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/S41419-023-05672-9","article-title":"Alpha-synuclein in Parkinson\u2019s disease and other synucleinopathies: From overt neurodegeneration back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell Death Dis."},{"key":"2024122414085603000_bib35","doi-asserted-by":"publisher","first-page":"17914","DOI":"10.1074\/jbc.M111.302794","article-title":"\u03b1-Synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions","volume":"287","author":"Cal\u00ec","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib36","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.3390\/CELLS9112513","article-title":"Therapeutic strategies to target calcium dysregulation in Alzheimer\u2019s disease","volume":"9","author":"Calvo-Rodriguez","year":"2020","journal-title":"Cells"},{"key":"2024122414085603000_bib37","doi-asserted-by":"publisher","first-page":"183064","DOI":"10.1016\/j.bbamem.2019.183064","article-title":"Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin","volume":"1862","author":"Camilleri","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"2024122414085603000_bib38","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fnagi.2019.00108","article-title":"Calcium ions stimulate the hyperphosphorylation of tau by activating microsomal prostaglandin E synthase 1","volume":"11","author":"Cao","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"2024122414085603000_bib39","doi-asserted-by":"publisher","first-page":"ENEURO.0007-20.2020","DOI":"10.1523\/ENEURO.0007-20.2020","article-title":"Snca-gfp knock-in mice reflect patterns of endogenous expression and pathological seeding","volume":"7","author":"Caputo","year":"2020","journal-title":"eNeuro"},{"key":"2024122414085603000_bib40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2114215119","article-title":"The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure","volume":"119","author":"Cario","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024122414085603000_bib41","doi-asserted-by":"publisher","first-page":"fcae256","DOI":"10.1093\/BRAINCOMMS\/FCAE256","article-title":"Drosophila appear resistant to trans-synaptic tau propagation","volume":"6","author":"Catterson","year":"2024","journal-title":"Brain Commun."},{"key":"2024122414085603000_bib42","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.19.572292","article-title":"GSK3\u03b2 phosphorylation catalyzes the aggregation of Tau into Alzheimer\u2019s disease-like amyloid strain","author":"Chakraborty","year":"2023","journal-title":"bioRxiv"},{"key":"2024122414085603000_bib43","doi-asserted-by":"publisher","first-page":"102678","DOI":"10.1016\/J.SBI.2023.102678","article-title":"Role of aberrant phase separation in pathological protein aggregation","volume":"82","author":"Chakraborty","year":"2023","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2024122414085603000_bib44","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0052056","article-title":"Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer\u2019s disease","volume":"7","author":"Chakroborty","year":"2012","journal-title":"PLoS One"},{"key":"2024122414085603000_bib45","doi-asserted-by":"publisher","first-page":"8341","DOI":"10.1523\/JNEUROSCI.0936-12.2012","article-title":"Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer\u2019s disease mice","volume":"32","author":"Chakroborty","year":"2012","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib46","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/J.CELL.2005.09.028","article-title":"\u03b1-synuclein cooperates with CSPalpha in preventing neurodegeneration","volume":"123","author":"Chandra","year":"2005","journal-title":"Cell"},{"key":"2024122414085603000_bib47","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","article-title":"Alpha-synuclein locus duplication as a cause of familial Parkinson\u2019s disease","volume":"364","author":"Chartier-Harlin","year":"2004","journal-title":"Lancet"},{"key":"2024122414085603000_bib48","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.78055","article-title":"Synaptic location is a determinant of the detrimental effects of \u03b1-synuclein pathology to glutamatergic transmission in the basolateral amygdala","volume":"11","author":"Chen","year":"2022","journal-title":"Elife"},{"key":"2024122414085603000_bib49","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/ANA.21995","article-title":"Clinical progression in Parkinson disease and the neurobiology of axons","volume":"67","author":"Cheng","year":"2010","journal-title":"Ann. Neurol."},{"key":"2024122414085603000_bib50","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1038\/s41593-022-01140-3","article-title":"Pathological structural conversion of \u03b1-synuclein at the mitochondria induces neuronal toxicity","volume":"25","author":"Choi","year":"2022","journal-title":"Nat. Neurosci."},{"key":"2024122414085603000_bib51","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1093\/brain\/awae002","article-title":"Nigrostriatal tau pathology in parkinsonism and Parkinson\u2019s disease","volume":"147","author":"Chu","year":"2024","journal-title":"Brain"},{"key":"2024122414085603000_bib52","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/J.CELS.2017.01.002","article-title":"In situ peroxidase labeling and mass-spectrometry connects alpha-synuclein directly to endocytic trafficking and mRNA metabolism in neurons","volume":"4","author":"Chung","year":"2017","journal-title":"Cell Syst."},{"key":"2024122414085603000_bib53","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1016\/j.neuron.2023.04.020","article-title":"Synaptic oligomeric tau in Alzheimer\u2019s disease - A potential culprit in the spread of tau pathology through the brain","volume":"111","author":"Colom-Cadena","year":"2023","journal-title":"Neuron"},{"key":"2024122414085603000_bib54","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1126\/science.1101738","article-title":"Impaired degradation of mutant \u03b1-synuclein by chaperone-mediated autophagy","volume":"305","author":"Cuervo","year":"2004","journal-title":"Science"},{"key":"2024122414085603000_bib55","doi-asserted-by":"publisher","first-page":"110672","DOI":"10.1016\/j.brainresbull.2023.110672","article-title":"Glucose metabolism impairment in Parkinson\u2019s disease","volume":"199","author":"Dai","year":"2023","journal-title":"Brain Res. Bull."},{"key":"2024122414085603000_bib56","doi-asserted-by":"publisher","DOI":"10.21203\/RS.3.RS-1522321\/V1","article-title":"Truncated tau disrupts autophagy and lysosomal biogenesis","author":"Dakkak","year":"2022","journal-title":"Res. Square"},{"key":"2024122414085603000_bib57","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/NN.2709","article-title":"Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer\u2019s disease","volume":"14","author":"D\u2019Amelio","year":"2011","journal-title":"Nat. Neurosci."},{"key":"2024122414085603000_bib58","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1002\/alz.12325","article-title":"Age-related calcium dysregulation linked with tau pathology and impaired cognition in non-human primates","volume":"17","author":"Datta","year":"2021","journal-title":"Alzheimers Dement."},{"key":"2024122414085603000_bib59","doi-asserted-by":"publisher","first-page":"790721","DOI":"10.3389\/FCELL.2021.790721","article-title":"Presynaptic autophagy and the connection with neurotransmission","volume":"9","author":"Decet","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"2024122414085603000_bib60","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/S40478-015-0193-3","article-title":"Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation","volume":"3","author":"Decker","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"2024122414085603000_bib61","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/978-981-32-9358-8_8","article-title":"Presynaptic pathophysiology encoded in different domains of tau - hyper-versus hypoexcitability?","volume":"1184","author":"Decker","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"2024122414085603000_bib62","doi-asserted-by":"publisher","first-page":"12535","DOI":"10.1523\/JNEUROSCI.1920-10.2010","article-title":"Pathogenic lysosomal depletion in Parkinson\u2019s disease","volume":"30","author":"Dehay","year":"2010","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib63","doi-asserted-by":"publisher","first-page":"jcs258785","DOI":"10.1242\/jcs.258785","article-title":"Dynamic remodeling of ribosomes and endoplasmic reticulum in axon terminals of motoneurons","volume":"134","author":"Deng","year":"2021","journal-title":"J. Cell Sci."},{"key":"2024122414085603000_bib64","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nrn.2017.170","article-title":"Mitochondria at the neuronal presynapse in health and disease","volume":"19","author":"Devine","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"2024122414085603000_bib65","doi-asserted-by":"publisher","first-page":"10520","DOI":"10.1021\/bi0493160","article-title":"Tau induces ring and microtubule formation from alphabeta-tubulin dimers under nonassembly conditions","volume":"43","author":"Devred","year":"2004","journal-title":"Biochemistry"},{"key":"2024122414085603000_bib66","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.00592","article-title":"Native \u03b1-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2\/VAMP2","volume":"2","author":"Diao","year":"2013","journal-title":"Elife"},{"key":"2024122414085603000_bib67","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024122414085603000_bib68","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.15252\/embr.201744137","article-title":"Bin1 directly remodels actin dynamics through its BAR domain","volume":"18","author":"Dr\u00e4ger","year":"2017","journal-title":"EMBO Rep."},{"key":"2024122414085603000_bib69","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1093\/brain\/awaa223","article-title":"Phosphorylated tau interactome in the human Alzheimer\u2019s disease brain","volume":"143","author":"Drummond","year":"2020","journal-title":"Brain"},{"key":"2024122414085603000_bib70","doi-asserted-by":"publisher","first-page":"14508","DOI":"10.1523\/JNEUROSCI.1560-11.2011","article-title":"Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of \u03b1-synuclein","volume":"31","author":"Ebrahimi-Fakhari","year":"2011","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib71","doi-asserted-by":"publisher","first-page":"6838","DOI":"10.1523\/JNEUROSCI.5699-09.2010","article-title":"Cell-produced \u03b1-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival","volume":"30","author":"Emmanouilidou","year":"2010","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib72","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/febs.15340","article-title":"Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase","volume":"288","author":"Esteras","year":"2021","journal-title":"FEBS J."},{"key":"2024122414085603000_bib73","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/j.bbadis.2018.11.014","article-title":"Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer\u2019s and Parkinson disease pathology","volume":"1865","author":"Esteves","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"2024122414085603000_bib74","doi-asserted-by":"publisher","DOI":"10.15252\/EMBJ.2018101174","article-title":"Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling","volume":"38","author":"Evans","year":"2019","journal-title":"EMBO J."},{"key":"2024122414085603000_bib75","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/S40478-021-01208-4","article-title":"Altered ribosomal function and protein synthesis caused by tau","volume":"9","author":"Evans","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"2024122414085603000_bib76","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s40478-019-0821-4","article-title":"Exosome release and neuropathology induced by \u03b1-synuclein: New insights into protective mechanisms of Drp1 inhibition","volume":"7","author":"Fan","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"2024122414085603000_bib77","doi-asserted-by":"publisher","first-page":"fcae107","DOI":"10.1093\/BRAINCOMMS\/FCAE107","article-title":"Synaptic density patterns in early Alzheimer\u2019s disease assessed by independent component analysis","volume":"6","author":"Fang","year":"2024","journal-title":"Brain Commun."},{"key":"2024122414085603000_bib78","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.celrep.2019.06.013","article-title":"Neuronal soma-derived degradative lysosomes are continuously delivered to distal axons to maintain local degradation capacity","volume":"28","author":"Farfel-Becker","year":"2019","journal-title":"Cell Rep."},{"key":"2024122414085603000_bib79","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1080\/15548627.2019.1633862","article-title":"MAPT\/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: A vicious cycle in alzheimer neurodegeneration","volume":"16","author":"Feng","year":"2020","journal-title":"Autophagy"},{"key":"2024122414085603000_bib80","doi-asserted-by":"publisher","DOI":"10.1002\/CPCB.51","article-title":"Transcription factor-mediated differentiation of human iPSCs into neurons","volume":"79","author":"Fernandopulle","year":"2018","journal-title":"Curr. Protoc. Cell Biol."},{"key":"2024122414085603000_bib81","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/s41467-019-13745-7","article-title":"Arginine \u03c0-stacking drives binding to fibrils of the Alzheimer protein Tau","volume":"11","author":"Ferrari","year":"2020","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib82","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nature23002","article-title":"Cryo-EM structures of tau filaments from Alzheimer\u2019s disease","volume":"547","author":"Fitzpatrick","year":"2017","journal-title":"Nature"},{"key":"2024122414085603000_bib83","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/S12640-012-9366-Z","article-title":"Potassium depolarization and raised calcium induces \u03b1-synuclein aggregates","volume":"23","author":"Follett","year":"2013","journal-title":"Neurotox. Res."},{"key":"2024122414085603000_bib309","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01801-5","article-title":"Tau filaments are tethered within brain extracellular vesicles in Alzheimer\u2019s disease","author":"Fowler","year":"2024","journal-title":"Nat. Neurosci."},{"key":"2024122414085603000_bib85","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0062143","article-title":"Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis","volume":"8","author":"Freeman","year":"2013","journal-title":"PLoS One"},{"key":"2024122414085603000_bib86","doi-asserted-by":"publisher","first-page":"12563","DOI":"10.1038\/NCOMMS12563","article-title":"Structural basis of synaptic vesicle assembly promoted by \u03b1-synuclein","volume":"7","author":"Fusco","year":"2016","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib87","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s00401-023-02657-y","article-title":"Distinct tau and alpha-synuclein molecular signatures in Alzheimer\u2019s disease with and without Lewy bodies and Parkinson\u2019s disease with dementia","volume":"147","author":"van der Gaag","year":"2024","journal-title":"Acta Neuropathol."},{"key":"2024122414085603000_bib88","doi-asserted-by":"publisher","first-page":"14241","DOI":"10.1074\/jbc.RA119.008733","article-title":"Autophagy activation promotes clearance of \u03b1-synuclein inclusions in fibril-seeded human neural cells","volume":"294","author":"Gao","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib89","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1093\/BRAIN\/AWQ132","article-title":"SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson\u2019s disease","volume":"133","author":"Garcia-Reitb\u00f6ck","year":"2010","journal-title":"Brain"},{"key":"2024122414085603000_bib90","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1074\/JBC.M008919200","article-title":"A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly","volume":"276","author":"Giasson","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib91","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1016\/J.STEMCR.2022.07.011","article-title":"Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol","volume":"17","author":"Glasauer","year":"2022","journal-title":"Stem Cell Rep."},{"key":"2024122414085603000_bib92","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.3233\/JPD-179005","article-title":"The synucleinopathies: Twenty years on","volume":"7","author":"Goedert","year":"2017","journal-title":"J. Parkinsons Dis."},{"key":"2024122414085603000_bib93","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1172\/JCI45803","article-title":"Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases","volume":"121","author":"Goldstein","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2024122414085603000_bib94","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.neurobiolaging.2020.06.004","article-title":"Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy","volume":"94","author":"Gomez-Murcia","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"2024122414085603000_bib95","doi-asserted-by":"publisher","first-page":"4586","DOI":"10.1038\/s41467-022-32350-9","article-title":"Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau","volume":"13","author":"Gracia","year":"2022","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib96","doi-asserted-by":"publisher","first-page":"19573","DOI":"10.1073\/pnas.1005005107","article-title":"\u03b1\u03b2\u03b3-Synuclein triple knockout mice revealage-dependent neuronal dysfunction","volume":"107","author":"Greten-Harrison","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024122414085603000_bib97","doi-asserted-by":"publisher","first-page":"102888","DOI":"10.1016\/J.JBC.2023.102888","article-title":"Fibril treatment changes protein interactions of tau and \u03b1-synuclein in human neurons","volume":"299","author":"Griffin","year":"2023","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib98","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1523\/JNEUROSCI.2507-13.2014","article-title":"\u03b1-Synuclein is localized to mitochondria-associated ER membranes","volume":"34","author":"Guardia-Laguarta","year":"2014","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib99","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/S00109-012-0984-Y","article-title":"LRRK2 interactions with \u03b1-synuclein in Parkinson\u2019s disease brains and in cell models","volume":"91","author":"Guerreiro","year":"2013","journal-title":"J. Mol. Med."},{"key":"2024122414085603000_bib100","doi-asserted-by":"publisher","first-page":"829354","DOI":"10.3389\/fnsyn.2022.829354","article-title":"Organization of presynaptic autophagy-related processes","volume":"14","author":"Gundelfinger","year":"2022","journal-title":"Front. Synaptic Neurosci."},{"key":"2024122414085603000_bib101","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.15252\/embj.201593594","article-title":"The effects of proteasomal inhibition on synaptic proteostasis","volume":"35","author":"Hakim","year":"2016","journal-title":"EMBO J."},{"key":"2024122414085603000_bib102","doi-asserted-by":"publisher","first-page":"6221","DOI":"10.1523\/JNEUROSCI.2552-14.2015","article-title":"Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer\u2019s disease","volume":"35","author":"Hall","year":"2015","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib103","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/B978-0-323-89906-2.00006-X","article-title":"Chapter 7 - autophagy and tau protein","volume-title":"Autophagy Dysfunction in Alzheimer\u2019s Disease and Dementia","author":"Hamano","year":"2022"},{"key":"2024122414085603000_bib104","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/J.1750-3639.2000.TB00269.X","article-title":"Lewy bodies in Alzheimer\u2019s disease: A neuropathological review of 145 cases using \u03b1-synuclein immunohistochemistry","volume":"10","author":"Hamilton","year":"2000","journal-title":"Brain Pathol."},{"key":"2024122414085603000_bib105","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1093\/JMCB\/MJAA075","article-title":"Observation of an \u03b1-synuclein liquid droplet state and its maturation into Lewy body-like assemblies","volume":"13","author":"Hardenberg","year":"2021","journal-title":"J. Mol. Cell Biol."},{"key":"2024122414085603000_bib106","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0029460","article-title":"The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of \u03b1-synuclein","volume":"6","author":"Hasegawa","year":"2011","journal-title":"PLoS One"},{"key":"2024122414085603000_bib107","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1038\/s41467-019-10278-x","article-title":"Tau binding protein CAPON induces tau aggregation and neurodegeneration","volume":"10","author":"Hashimoto","year":"2019","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib108","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/J.NEURON.2012.02.020","article-title":"Regulation of presynaptic neurotransmission by macroautophagy","volume":"74","author":"Hernandez","year":"2012","journal-title":"Neuron"},{"key":"2024122414085603000_bib109","doi-asserted-by":"publisher","DOI":"10.1101\/2023.07.04.547658","article-title":"Synaptogyrin regulates neuronal activity dependent autophagy to degrade synaptic vesicle components and pathological Tau","author":"Hernandez-Diaz","year":"2023","journal-title":"bioRxiv"},{"key":"2024122414085603000_bib110","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1016\/j.celrep.2017.08.042","article-title":"Local nucleation of microtubule bundles through tubulin concentration into a condensed tau phase","volume":"20","author":"Hern\u00e1ndez-Vega","year":"2017","journal-title":"Cell Rep."},{"key":"2024122414085603000_bib111","doi-asserted-by":"publisher","first-page":"12473","DOI":"10.1038\/s41598-019-48790-1","article-title":"Dynamical decoration of stabilized-microtubules by Tau-proteins","volume":"9","author":"Hervy","year":"2019","journal-title":"Sci. Rep."},{"key":"2024122414085603000_bib112","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s42003-022-03124-2","article-title":"Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory","volume":"5","author":"Hiess","year":"2022","journal-title":"Commun. Biol."},{"key":"2024122414085603000_bib113","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/J.DEVCEL.2019.02.013","article-title":"Maturation and clearance of autophagosomes in neurons depends on a specific cysteine protease isoform, ATG-4.2","volume":"49","author":"Hill","year":"2019","journal-title":"Dev. Cell"},{"key":"2024122414085603000_bib114","doi-asserted-by":"publisher","first-page":"13233","DOI":"10.1038\/ncomms13233","article-title":"Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport","volume":"7","author":"Hinckelmann","year":"2016","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib115","doi-asserted-by":"publisher","DOI":"10.1101\/2024.02.12.579972","article-title":"Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP","author":"Hirabayashi","year":"2024","journal-title":"bioRxiv"},{"key":"2024122414085603000_bib116","doi-asserted-by":"publisher","first-page":"6730","DOI":"10.1038\/s41467-023-42372-6","article-title":"Synapsin condensation controls synaptic vesicle sequestering and dynamics","volume":"14","author":"Hoffmann","year":"2023","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib117","doi-asserted-by":"publisher","first-page":"166961","DOI":"10.1016\/J.JMB.2021.166961","article-title":"Synapsin condensates recruit alpha-synuclein","volume":"433","author":"Hoffmann","year":"2021","journal-title":"J. Mol. Biol."},{"key":"2024122414085603000_bib118","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41531-024-00655-9","article-title":"Synaptic loss and its association with symptom severity in Parkinson\u2019s disease","volume":"10","author":"Holmes","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"key":"2024122414085603000_bib119","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73542","article-title":"Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer\u2019s disease mice synapse model","volume":"11","author":"Hori","year":"2022","journal-title":"Elife"},{"key":"2024122414085603000_bib120","doi-asserted-by":"publisher","DOI":"10.1101\/2021.05.10.443522.xf","article-title":"Exosomal transmission of \u03b1-synuclein initiates Parkinson\u2019s disease-like pathology","author":"Howitt","year":"2021","journal-title":"bioRxiv"},{"key":"2024122414085603000_bib121","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/J.BBRC.2022.02.097","article-title":"Calcium promotes \u03b1-synuclein liquid-liquid phase separation to accelerate amyloid aggregation","volume":"603","author":"Huang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2024122414085603000_bib122","doi-asserted-by":"publisher","first-page":"5929","DOI":"10.1074\/jbc.M211617200","article-title":"Glycolysis and glutamate accumulation into synaptic vesicles. Role of glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase","volume":"278","author":"Ikemoto","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib123","doi-asserted-by":"publisher","first-page":"34904","DOI":"10.1038\/srep34904","article-title":"Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons","volume":"6","author":"Imamura","year":"2016","journal-title":"Sci. Rep."},{"key":"2024122414085603000_bib124","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1093\/BRAIN\/AWV222","article-title":"Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations","volume":"138","author":"Iovino","year":"2015","journal-title":"Brain"},{"key":"2024122414085603000_bib125","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.3390\/biomedicines10071550","article-title":"NMDA and AMPA receptors at synapses: Novel targets for tau and \u03b1-synuclein proteinopathies","volume":"10","author":"Italia","year":"2022","journal-title":"Biomedicines"},{"key":"2024122414085603000_bib126","doi-asserted-by":"publisher","first-page":"826098","DOI":"10.3389\/fnsyn.2022.826098","article-title":"Synaptic vesicle recycling and the endolysosomal system: A reappraisal of form and function","volume":"14","author":"Ivanova","year":"2022","journal-title":"Front. Synaptic Neurosci."},{"key":"2024122414085603000_bib127","doi-asserted-by":"publisher","first-page":"180142","DOI":"10.1038\/sdata.2018.142","article-title":"A multi-omic atlas of the human frontal cortex for aging and Alzheimer\u2019s disease research","volume":"5","author":"De Jager","year":"2018","journal-title":"Sci. Data"},{"key":"2024122414085603000_bib128","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0014-5793(94)00395-5","article-title":"Identification of two distinct synucleins from human brain","volume":"345","author":"Jakes","year":"1994","journal-title":"FEBS Lett."},{"key":"2024122414085603000_bib129","doi-asserted-by":"publisher","first-page":"E4016","DOI":"10.1073\/pnas.1309143110","article-title":"Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model","volume":"110","author":"Janezic","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024122414085603000_bib130","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.neuron.2016.03.011","article-title":"Glycolytic enzymes localize to synapses under energy stress to support synaptic function","volume":"90","author":"Jang","year":"2016","journal-title":"Neuron"},{"key":"2024122414085603000_bib131","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nature12481","article-title":"Self-propagation of pathogenic protein aggregates in neurodegenerative diseases","volume":"501","author":"Jucker","year":"2013","journal-title":"Nature"},{"key":"2024122414085603000_bib132","doi-asserted-by":"publisher","DOI":"10.1101\/2024.08.27.609924","article-title":"Behavioral screening defines three molecular Parkinsonism subgroups in Drosophila","author":"Kaempf","year":"2024","journal-title":"bioRxiv"},{"key":"2024122414085603000_bib133","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.15252\/embj.201592770","article-title":"\u03b1-Synuclein oligomers pump it up!","volume":"34","author":"Kahle","year":"2015","journal-title":"EMBO J."},{"key":"2024122414085603000_bib134","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1016\/j.neuron.2023.05.011","article-title":"Profiling of purified autophagic vesicle degradome in the maturing and aging brain","volume":"111","author":"Kallergi","year":"2023","journal-title":"Neuron"},{"key":"2024122414085603000_bib135","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1038\/s41467-020-16580-3","article-title":"Liquid-liquid phase separation induces pathogenic tau conformations in vitro","volume":"11","author":"Kanaan","year":"2020","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib136","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1016\/j.celrep.2018.04.056","article-title":"Unconventional secretion mediates the trans-cellular spreading of tau","volume":"23","author":"Katsinelos","year":"2018","journal-title":"Cell Rep."},{"key":"2024122414085603000_bib137","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/S41580-018-0001-6","article-title":"The coming of age of chaperone-mediated autophagy","volume":"19","author":"Kaushik","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024122414085603000_bib138","doi-asserted-by":"publisher","DOI":"10.1172\/JCI169064","article-title":"KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss","volume":"134","author":"Kauwe","year":"2024","journal-title":"J. Clin. Invest."},{"key":"2024122414085603000_bib139","doi-asserted-by":"publisher","DOI":"10.1101\/2024.11.21.624639","article-title":"Soma-centered control of synaptic autophagy by Rab39-regulated anterograde trafficking of Atg9","author":"Kilic","year":"2024","journal-title":"bioRxiv"},{"key":"2024122414085603000_bib140","doi-asserted-by":"publisher","DOI":"10.1101\/2023.11.22.568357","article-title":"Inhibition of FAM19A5 restores synaptic loss and improves cognitive function in mouse models of Alzheimer\u2019s disease","author":"Kim","year":"2024","journal-title":"bioRxiv"},{"key":"2024122414085603000_bib141","doi-asserted-by":"publisher","first-page":"387","DOI":"10.4196\/kjpp.2016.20.4.387","article-title":"Sequestration of sorcin by aberrant forms of tau results in the defective calcium homeostasis","volume":"20","author":"Kim","year":"2016","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"2024122414085603000_bib142","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1083\/jcb.201709072","article-title":"Pathways of cellular proteostasis in aging and disease","volume":"217","author":"Klaips","year":"2018","journal-title":"J. Cell Biol."},{"key":"2024122414085603000_bib143","doi-asserted-by":"publisher","DOI":"10.1038\/CDDIS.2015.169","article-title":"Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons","volume":"6","author":"Koch","year":"2015","journal-title":"Cell Death Dis."},{"key":"2024122414085603000_bib144","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/BF00685366","article-title":"Presenile dementia with Alzheimer-, Pick- and Lewy-body changes","volume":"36","author":"Kosaka","year":"1976","journal-title":"Acta Neuropathol."},{"key":"2024122414085603000_bib145","doi-asserted-by":"publisher","first-page":"742625","DOI":"10.3389\/fneur.2021.742625","article-title":"Endoplasmic reticulum-based calcium dysfunctions in synucleinopathies","volume":"12","author":"Kovacs","year":"2021","journal-title":"Front. Neurol."},{"key":"2024122414085603000_bib146","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/J.NEURON.2020.10.005","article-title":"Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum","volume":"109","author":"Kuijpers","year":"2021","journal-title":"Neuron"},{"key":"2024122414085603000_bib147","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s42003-019-0644-7","article-title":"Partially oxidized DJ-1 inhibits \u03b1-synuclein nucleation and remodels mature \u03b1-synuclein fibrils in vitro","volume":"2","author":"Kumar","year":"2019","journal-title":"Commun. Biol."},{"key":"2024122414085603000_bib148","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1016\/j.jmb.2016.03.010","article-title":"Regulation of microtubule assembly by tau and not by Pin1","volume":"428","author":"Kutter","year":"2016","journal-title":"J. Mol. Biol."},{"key":"2024122414085603000_bib149","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.neuron.2020.12.016","article-title":"Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation","volume":"109","author":"Largo-Barrientos","year":"2021","journal-title":"Neuron"},{"key":"2024122414085603000_bib150","doi-asserted-by":"publisher","first-page":"11915","DOI":"10.1523\/JNEUROSCI.3821-06.2006","article-title":"\u03b1-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis","volume":"26","author":"Larsen","year":"2006","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib151","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3389\/fnmol.2018.00421","article-title":"Structural basis of tau interaction with BIN1 and regulation by tau phosphorylation","volume":"11","author":"Lasorsa","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"2024122414085603000_bib152","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.tcb.2017.02.002","article-title":"\u03b1-Synuclein - regulator of exocytosis, endocytosis, or both?","volume":"27","author":"Lautenschl\u00e4ger","year":"2017","journal-title":"Trends Cell Biol."},{"key":"2024122414085603000_bib153","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/s41467-018-03111-4","article-title":"C-terminal calcium binding of \u03b1-synuclein modulates synaptic vesicle interaction","volume":"9","author":"Lautenschl\u00e4ger","year":"2018","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib154","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","article-title":"Faulty autolysosome acidification in Alzheimer\u2019s disease mouse models induces autophagic build-up of A\u03b2 in neurons, yielding senile plaques","volume":"25","author":"Lee","year":"2022","journal-title":"Nat. Neurosci."},{"key":"2024122414085603000_bib155","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41419-019-1364-0","article-title":"A30P mutant \u03b1-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons","volume":"10","author":"Lei","year":"2019","journal-title":"Cell Death Dis."},{"key":"2024122414085603000_bib156","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1038\/s42003-021-02624-x","article-title":"Selectivity of Lewy body protein interactions along the aggregation pathway of \u03b1-synuclein","volume":"4","author":"Leit\u00e3o","year":"2021","journal-title":"Commun. Biol."},{"key":"2024122414085603000_bib157","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/JNC.13713","article-title":"Synaptopathies: Synaptic dysfunction in neurological disorders - a review from students to students","volume":"138","author":"Lepeta","year":"2016","journal-title":"J. Neurochem."},{"key":"2024122414085603000_bib158","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40779-022-00396-x","article-title":"Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling","volume":"9","author":"Li","year":"2022","journal-title":"Mil. Med. Res."},{"key":"2024122414085603000_bib159","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41583-021-00535-8","article-title":"Energy matters: Presynaptic metabolism and the maintenance of synaptic transmission","volume":"23","author":"Li","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"2024122414085603000_bib160","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1097\/WNR.0B013E3282F03DB4","article-title":"Localization of alpha-synuclein to mitochondria within midbrain of mice","volume":"18","author":"Li","year":"2007","journal-title":"Neuroreport"},{"key":"2024122414085603000_bib161","doi-asserted-by":"publisher","first-page":"101914","DOI":"10.1016\/j.arr.2023.101914","article-title":"The endoplasmic reticulum stress and unfolded protein response in Alzheimer\u2019s disease: A calcium dyshomeostasis perspective","volume":"87","author":"Lim","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"2024122414085603000_bib162","doi-asserted-by":"publisher","first-page":"10076","DOI":"10.1523\/JNEUROSCI.0618-11.2011","article-title":"\u03b1-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies","volume":"31","author":"Lim","year":"2011","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib163","doi-asserted-by":"publisher","first-page":"5301","DOI":"10.1016\/s0021-9258(17)42989-9","article-title":"Phosphorylation affects the ability of tau protein to promote microtubule assembly","volume":"259","author":"Lindwall","year":"1984","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib164","doi-asserted-by":"publisher","first-page":"633727","DOI":"10.3389\/fncel.2021.633727","article-title":"The membrane interaction of alpha-synuclein","volume":"15","author":"Liu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"2024122414085603000_bib165","doi-asserted-by":"publisher","first-page":"102697","DOI":"10.1016\/J.REDOX.2023.102697","article-title":"Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis","volume":"62","author":"Liu","year":"2023","journal-title":"Redox Biol."},{"key":"2024122414085603000_bib166","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1074\/MCP.RA118.001290","article-title":"Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer\u2019s disease cerebrospinal fluid","volume":"18","author":"Lle\u00f3","year":"2019","journal-title":"Mol. Cell. Proteomics"},{"key":"2024122414085603000_bib167","doi-asserted-by":"publisher","first-page":"7277","DOI":"10.1038\/S41467-023-43130-4","article-title":"Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles","volume":"14","author":"Longfield","year":"2023","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib168","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76494","article-title":"Assembly of recombinant tau into filaments identical to those of Alzheimer\u2019s disease and chronic traumatic encephalopathy","volume":"11","author":"L\u00f6vestam","year":"2022","journal-title":"Elife"},{"key":"2024122414085603000_bib169","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41586-023-06788-w","article-title":"Disease-specific tau filaments assemble via polymorphic intermediates","volume":"625","author":"L\u00f6vestam","year":"2024","journal-title":"Nature"},{"key":"2024122414085603000_bib170","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/s41419-023-06251-8","article-title":"Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization","volume":"14","author":"Lurette","year":"2023","journal-title":"Cell Death Dis."},{"key":"2024122414085603000_bib171","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1093\/PLPHYS\/KIAB479","article-title":"Advances in enzyme-mediated proximity labeling and its potential for plant research","volume":"188","author":"Mair","year":"2022","journal-title":"Plant Physiol."},{"key":"2024122414085603000_bib172","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1093\/HMG\/DDS072","article-title":"Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer\u2019s disease neurons: Implications for mitochondrial dysfunction and neuronal damage","volume":"21","author":"Manczak","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"2024122414085603000_bib173","doi-asserted-by":"publisher","first-page":"5131","DOI":"10.1093\/HMG\/DDS360","article-title":"Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer\u2019s disease","volume":"21","author":"Manczak","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"2024122414085603000_bib174","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0197-4580(95)00025-A","article-title":"Tau domains, phosphorylation, and interactions with microtubules","volume":"16","author":"Mandelkow","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"2024122414085603000_bib175","doi-asserted-by":"publisher","first-page":"2804","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988","article-title":"Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal","volume":"8","author":"Maroteaux","year":"1988","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib176","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1172\/JCI32806","article-title":"Dopamine-modified \u03b1-synuclein blocks chaperone-mediated autophagy","volume":"118","author":"Martinez-Vicente","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2024122414085603000_bib177","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.neuron.2012.08.022","article-title":"LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis","volume":"75","author":"Matta","year":"2012","journal-title":"Neuron"},{"key":"2024122414085603000_bib178","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/S13024-021-00467-Y","article-title":"The informed road map to prevention of alzheimer disease: A call to arms","volume":"16","author":"McDade","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"2024122414085603000_bib179","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/J.NEURON.2018.01.022","article-title":"Synaptogyrin-3 mediates presynaptic dysfunction induced by tau","volume":"97","author":"McInnes","year":"2018","journal-title":"Neuron"},{"key":"2024122414085603000_bib180","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s40478-020-0894-0","article-title":"Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by \u03b1-synuclein","volume":"8","author":"McKinnon","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"2024122414085603000_bib181","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1093\/brain\/awad032","article-title":"Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change","volume":"146","author":"McMillan","year":"2023","journal-title":"Brain"},{"key":"2024122414085603000_bib182","doi-asserted-by":"publisher","first-page":"687","DOI":"10.3233\/JAD-150298","article-title":"Identification of novel tau interactions with endoplasmic reticulum proteins in Alzheimer\u2019s disease brain","volume":"48","author":"Meier","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"2024122414085603000_bib183","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1134\/S0006297920050090","article-title":"\u03b1-Synuclein overexpression in SH-SY5Y human neuroblastoma cells leads to the accumulation of thioflavin S-positive aggregates and impairment of glycolysis","volume":"85","author":"Melnikova","year":"2020","journal-title":"Biochemistry"},{"key":"2024122414085603000_bib184","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1038\/s41467-022-30461-x","article-title":"Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses","volume":"13","author":"Meng","year":"2022","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib185","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.neuron.2011.08.029","article-title":"Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission","volume":"72","author":"Milosevic","year":"2011","journal-title":"Neuron"},{"key":"2024122414085603000_bib186","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1126\/science.aat5671","article-title":"A liquid phase of synapsin and lipid vesicles","volume":"361","author":"Milovanovic","year":"2018","journal-title":"Science"},{"key":"2024122414085603000_bib187","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1038\/s41374-021-00644-z","article-title":"Exosomal tau with seeding activity is released from Alzheimer\u2019s disease synapses, and seeding potential is associated with amyloid beta","volume":"101","author":"Miyoshi","year":"2021","journal-title":"Lab. Invest."},{"key":"2024122414085603000_bib188","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13781","article-title":"Age-related deficits in neuronal physiology and cognitive function are recapitulated in young mice overexpressing the L-type calcium channel, CaV 1.3","volume":"22","author":"Moore","year":"2023","journal-title":"Aging Cell"},{"key":"2024122414085603000_bib189","doi-asserted-by":"publisher","first-page":"5979","DOI":"10.3390\/ijms20235979","article-title":"Zinc binding to tau influences aggregation kinetics and oligomer distribution","volume":"20","author":"Moreira","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2024122414085603000_bib190","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PBIO.1000034","article-title":"Structural polymorphism of 441-residue tau at single residue resolution","volume":"7","author":"Mukrasch","year":"2009","journal-title":"PLoS Biol."},{"key":"2024122414085603000_bib191","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2211999119","article-title":"Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer\u2019s disease","volume":"119","author":"Mustaly-Kalimi","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024122414085603000_bib192","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/J.CONB.2021.09.001","article-title":"Synaptic proteostasis in Parkinson\u2019s disease","volume":"72","author":"Nachman","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"key":"2024122414085603000_bib193","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1007\/S11064-020-03126-8","article-title":"\u03b1-Synuclein overexpression induces lysosomal dysfunction and autophagy impairment in human neuroblastoma SH-SY5Y","volume":"45","author":"Nascimento","year":"2020","journal-title":"Neurochem. Res."},{"key":"2024122414085603000_bib194","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.mcn.2010.12.004","article-title":"Raised calcium promotes \u03b1-synuclein aggregate formation","volume":"46","author":"Nath","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"2024122414085603000_bib195","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.neuron.2009.12.023","article-title":"Increased expression of \u03b1-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis","volume":"65","author":"Nemani","year":"2010","journal-title":"Neuron"},{"key":"2024122414085603000_bib196","doi-asserted-by":"publisher","first-page":"22680","DOI":"10.1074\/jbc.M101181200","article-title":"Ca2+ binding to \u03b1-synuclein regulates ligand binding and oligomerization","volume":"276","author":"Nielsen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib197","doi-asserted-by":"publisher","first-page":"13862","DOI":"10.1074\/jbc.M114.634063","article-title":"Convergence of parkin, PINK1, and \u03b1-synuclein on stress-induced mitochondrial morphological remodeling","volume":"290","author":"Norris","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib198","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/jb\/mvx038","article-title":"Ca2+\/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262\/356 in a transgenic Drosophila model of tauopathy","volume":"162","author":"Oka","year":"2017","journal-title":"J. Biochem."},{"key":"2024122414085603000_bib199","doi-asserted-by":"publisher","DOI":"10.1038\/CDDIS.2015.318","article-title":"Elevated \u03b1-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson\u2019s patient-derived induced pluripotent stem cells","volume":"6","author":"Oliveira","year":"2015","journal-title":"Cell Death Dis."},{"key":"2024122414085603000_bib200","doi-asserted-by":"publisher","first-page":"5411","DOI":"10.1016\/j.cell.2023.09.028","article-title":"The proteomic landscape of synaptic diversity across brain regions and cell types","volume":"186","author":"van Oostrum","year":"2023","journal-title":"Cell"},{"key":"2024122414085603000_bib201","doi-asserted-by":"publisher","first-page":"11820","DOI":"10.1523\/JNEUROSCI.0875-12.2012","article-title":"Neurobiology of disease ryanodine receptor blockade reduces amyloid-load and memory impairments in Tg2576 mouse model of Alzheimer disease","volume":"32","author":"Oul\u00e8","year":"2012","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib202","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062459","article-title":"Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice","volume":"8","author":"Ozcelik","year":"2013","journal-title":"PLoS One"},{"key":"2024122414085603000_bib203","doi-asserted-by":"publisher","first-page":"4493","DOI":"10.1038\/s41467-021-24713-5","article-title":"ER \u2013 lysosome contacts at a pre-axonal region regulate axonal lysosome availability","volume":"12","author":"\u00d6zkan","year":"2021","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib204","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00401-017-1704-z","article-title":"\u03b1-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production","volume":"134","author":"Paillusson","year":"2017","journal-title":"Acta Neuropathol."},{"key":"2024122414085603000_bib205","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1007\/s12031-020-01776-5","article-title":"Tau in the pathophysiology of Parkinson\u2019s disease","volume":"71","author":"Pan","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"2024122414085603000_bib206","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/J.STEM.2022.11.004","article-title":"A reference human induced pluripotent stem cell line for large-scale collaborative studies","volume":"29","author":"Pantazis","year":"2022","journal-title":"Cell Stem Cell"},{"key":"2024122414085603000_bib207","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1111\/JNC.15174","article-title":"Distinct alpha-Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH-SY5Y cells","volume":"156","author":"Pantazopoulou","year":"2021","journal-title":"J. Neurochem."},{"key":"2024122414085603000_bib208","doi-asserted-by":"publisher","first-page":"8315","DOI":"10.1523\/jneurosci.0391-19.2019","article-title":"Drosophila tau negatively regulates translation and olfactory long-term memory, but facilitates footshock habituation and cytoskeletal homeostasis","volume":"39","author":"Papanikolopoulou","year":"2019","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib209","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0022-510X(89)90219-0","article-title":"Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)","volume":"94","author":"Papp","year":"1989","journal-title":"J. Neurol. Sci."},{"key":"2024122414085603000_bib210","doi-asserted-by":"publisher","first-page":"4006","DOI":"10.1016\/J.NEURON.2023.11.020","article-title":"Serine-129 phosphorylation of \u03b1-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function","volume":"111","author":"Parra-Rivas","year":"2023","journal-title":"Neuron"},{"key":"2024122414085603000_bib211","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.98348.1","article-title":"Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across 5 fly Parkinsonism models","volume":"13","author":"Pech","year":"2024","journal-title":"Elife"},{"key":"2024122414085603000_bib212","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/B978-0-12-819410-2.00022-9","article-title":"Synaptic dysfunction in early phases of Alzheimer\u2019s disease","volume":"184","author":"Pelucchi","year":"2022","journal-title":"Handb. Clin. Neurol."},{"key":"2024122414085603000_bib213","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1007\/s12035-017-0385-x","article-title":"Caspase-cleaved tau impairs mitochondrial dynamics in Alzheimer\u2019s disease","volume":"55","author":"P\u00e9rez","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"2024122414085603000_bib214","doi-asserted-by":"publisher","first-page":"102051","DOI":"10.1016\/j.pneurobio.2021.102051","article-title":"Presynaptic protein synthesis and brain plasticity: From physiology to neuropathology","volume":"202","author":"Perrone-Capano","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"2024122414085603000_bib215","doi-asserted-by":"publisher","first-page":"18024","DOI":"10.1038\/s41598-023-44979-7","article-title":"Tau accumulation in degradative organelles is associated to lysosomal stress","volume":"13","author":"Piovesana","year":"2023","journal-title":"Sci. Rep."},{"key":"2024122414085603000_bib216","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00401-020-02254-3","article-title":"Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol","volume":"141","author":"Polanco","year":"2021","journal-title":"Acta Neuropathol."},{"key":"2024122414085603000_bib217","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.3390\/cells10092229","article-title":"\u03b1-Synuclein decreases the abundance of proteasome subunits and alters ubiquitin conjugates in yeast","volume":"10","author":"Popova","year":"2021","journal-title":"Cells"},{"key":"2024122414085603000_bib218","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/J.NEURON.2023.02.033","article-title":"Neuronal identity defines \u03b1-synuclein and tau toxicity","volume":"111","author":"Praschberger","year":"2023","journal-title":"Neuron"},{"key":"2024122414085603000_bib219","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.ADD6260","article-title":"Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer\u2019s disease","volume":"384","author":"Princen","year":"2024","journal-title":"Science"},{"key":"2024122414085603000_bib220","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41531-023-00578-x","article-title":"Alpha synuclein modulates mitochondrial Ca2+ uptake from ER during cell stimulation and under stress conditions","volume":"9","author":"Ramezani","year":"2023","journal-title":"NPJ Parkinsons Dis."},{"key":"2024122414085603000_bib221","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/dvdy.24599","article-title":"ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule-associated proteins","volume":"247","author":"Ramkumar","year":"2018","journal-title":"Dev. Dyn."},{"key":"2024122414085603000_bib222","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.cell.2013.12.042","article-title":"Activity-driven local ATP synthesis is required for synaptic function","volume":"156","author":"Rangaraju","year":"2014","journal-title":"Cell"},{"key":"2024122414085603000_bib223","doi-asserted-by":"publisher","first-page":"19366","DOI":"10.1021\/ja2029848","article-title":"Mechanism of membrane interaction and disruption by \u03b1-synuclein","volume":"133","author":"Reynolds","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"2024122414085603000_bib224","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2315690121","article-title":"Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes","volume":"121","author":"Rose","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024122414085603000_bib225","doi-asserted-by":"publisher","first-page":"7150","DOI":"10.1021\/bi025777e","article-title":"\u03b1-helix structure in Alzheimer\u2019s disease aggregates of tau-protein","volume":"41","author":"Sadqi","year":"2002","journal-title":"Biochemistry"},{"key":"2024122414085603000_bib226","doi-asserted-by":"publisher","first-page":"12754","DOI":"10.1074\/jbc.RA119.009487","article-title":"Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation","volume":"294","author":"Saito","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib227","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1080\/15548627.2019.1643657","article-title":"Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading","volume":"16","author":"Sandhof","year":"2020","journal-title":"Autophagy"},{"key":"2024122414085603000_bib228","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"2024122414085603000_bib229","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.sbi.2020.05.011","article-title":"Cryo-EM structures of tau filaments","volume":"64","author":"Scheres","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2024122414085603000_bib230","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S0896-6273(03)00667-6","article-title":"Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin","volume":"40","author":"Schuske","year":"2003","journal-title":"Neuron"},{"key":"2024122414085603000_bib231","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1126\/SCIENCE.1074069","article-title":"Alzheimer\u2019s disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"key":"2024122414085603000_bib232","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/J.TINS.2022.11.007","article-title":"\u03b1-Synuclein in synaptic function and dysfunction","volume":"46","author":"Sharma","year":"2023","journal-title":"Trends Neurosci."},{"key":"2024122414085603000_bib233","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1101\/gad.320077.118","article-title":"Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity","volume":"33","author":"Shimojo","year":"2019","journal-title":"Genes Dev."},{"key":"2024122414085603000_bib234","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4382","article-title":"Liquid phase condensation in cell physiology and disease","volume":"357","author":"Shin","year":"2017","journal-title":"Science"},{"key":"2024122414085603000_bib235","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.15252\/embj.201591397","article-title":"\u03b1-synuclein assemblies sequester neuronal \u03b13-Na+\/K+-ATPase and impair Na+ gradient","volume":"34","author":"Shrivastava","year":"2015","journal-title":"EMBO J."},{"key":"2024122414085603000_bib236","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899871","article-title":"Clustering of Tau fibrils impairs the synaptic composition of \u03b13-Na+\/K+-ATPase and AMPA receptors","volume":"38","author":"Shrivastava","year":"2019","journal-title":"EMBO J."},{"key":"2024122414085603000_bib237","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1002\/PRO.4025","article-title":"Interplay between tau and \u03b1-synuclein liquid-liquid phase separation","volume":"30","author":"Siegert","year":"2021","journal-title":"Protein Sci."},{"key":"2024122414085603000_bib238","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1038\/s41467-020-16984-1","article-title":"Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons","volume":"11","author":"Silva","year":"2020","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib239","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/SCIENCE.1090278","article-title":"\u03b1-Synuclein locus triplication causes Parkinson\u2019s disease","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"key":"2024122414085603000_bib240","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAY4106","article-title":"An atlas of the protein-coding genes in the human, pig, and mouse brain","volume":"367","author":"Sj\u00f6stedt","year":"2020","journal-title":"Science"},{"key":"2024122414085603000_bib241","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1074\/JBC.REV118.006493","article-title":"Intrinsically disordered proteins in synaptic vesicle trafficking and release","volume":"294","author":"Snead","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib242","doi-asserted-by":"publisher","first-page":"11753","DOI":"10.1074\/JBC.M208641200","article-title":"Aggregated and monomeric \u03b1-synuclein bind to the S6\u2032 proteasomal protein and inhibit proteasomal function","volume":"278","author":"Snyder","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib243","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.neuron.2019.08.008","article-title":"Pathogenic tau impairs axon initial segment plasticity and excitability homeostasis","volume":"104","author":"Sohn","year":"2019","journal-title":"Neuron"},{"key":"2024122414085603000_bib244","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40478-015-0237-8","article-title":"Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau\u2019s proline-rich domain","volume":"3","author":"Sottejeau","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"2024122414085603000_bib245","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.neuron.2016.09.037","article-title":"A LRRK2-dependent EndophilinA phosphoswitch is critical for macroautophagy at presynaptic terminals","volume":"92","author":"Soukup","year":"2016","journal-title":"Neuron"},{"key":"2024122414085603000_bib246","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1080\/15548627.2017.1286440","article-title":"EndoA\/Endophilin-A creates docking stations for autophagic proteins at synapses","volume":"13","author":"Soukup","year":"2017","journal-title":"Autophagy"},{"key":"2024122414085603000_bib247","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"2024122414085603000_bib248","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/S00401-017-1709-7","article-title":"Interactions of pathological proteins in neurodegenerative diseases","volume":"134","author":"Spires-Jones","year":"2017","journal-title":"Acta Neuropathol."},{"key":"2024122414085603000_bib249","doi-asserted-by":"publisher","first-page":"15231","DOI":"10.1038\/s41598-022-18648-0","article-title":"Tau isoform-specific enhancement of L-type calcium current and augmentation of afterhyperpolarization in rat hippocampal neurons","volume":"12","author":"Stan","year":"2022","journal-title":"Sci. Rep."},{"key":"2024122414085603000_bib250","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/JNC.14704","article-title":"How is alpha-synuclein cleared from the cell?","volume":"150","author":"Stefanis","year":"2019","journal-title":"J. Neurochem."},{"key":"2024122414085603000_bib251","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1074\/jbc.RA118.001784","article-title":"An N-terminal motif unique to primate tau enables differential protein-protein interactions","volume":"293","author":"Stefanoska","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib252","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.56825","article-title":"\u03b1-synuclein strains that cause distinct pathologies differentially inhibit proteasome","volume":"9","author":"Suzuki","year":"2020","journal-title":"Elife"},{"key":"2024122414085603000_bib253","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1016\/j.ajpath.2012.06.033","article-title":"The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system","volume":"181","author":"Tai","year":"2012","journal-title":"Am. J. Pathol."},{"key":"2024122414085603000_bib254","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/s41419-021-04138-0","article-title":"Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion","volume":"12","author":"Tang","year":"2021","journal-title":"Cell Death Dis."},{"key":"2024122414085603000_bib255","doi-asserted-by":"publisher","first-page":"180138","DOI":"10.1098\/RSOB.180138","article-title":"Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: An overview of induced pluripotent stem-cell-based disease models","volume":"8","author":"Taoufik","year":"2018","journal-title":"Open Biol."},{"key":"2024122414085603000_bib256","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.3390\/BIOM11091333","article-title":"Alpha-synuclein and the endolysosomal system in Parkinson\u2019s disease: Guilty by association","volume":"11","author":"Teixeira","year":"2021","journal-title":"Biomolecules"},{"key":"2024122414085603000_bib257","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nature16531","article-title":"Structural disorder of monomeric \u03b1-synuclein persists in mammalian cells","volume":"530","author":"Theillet","year":"2016","journal-title":"Nature"},{"key":"2024122414085603000_bib258","doi-asserted-by":"publisher","first-page":"947191","DOI":"10.3389\/fnmol.2022.947191","article-title":"The relationship of alpha-synuclein to mitochondrial dynamics and quality control","volume":"15","author":"Thorne","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"2024122414085603000_bib259","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0006-8993(03)03040-3","article-title":"\u03b1-synuclein expression localizes to the Golgi apparatus in bovine adrenal medullary chromaffin cells","volume":"984","author":"Tompkins","year":"2003","journal-title":"Brain Res."},{"key":"2024122414085603000_bib260","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12929-022-00871-6","article-title":"Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies","volume":"29","author":"Tong","year":"2022","journal-title":"J. Biomed. Sci."},{"key":"2024122414085603000_bib261","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1038\/s41598-022-06846-9","article-title":"Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation","volume":"12","author":"Torres-Garcia","year":"2022","journal-title":"Sci. Rep."},{"key":"2024122414085603000_bib262","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.cell.2021.12.041","article-title":"Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration","volume":"185","author":"Tracy","year":"2022","journal-title":"Cell"},{"key":"2024122414085603000_bib263","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13024-019-0320-x","article-title":"\u03b1-synuclein in the pathophysiology of Alzheimer\u2019s disease","volume":"14","author":"Twohig","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"2024122414085603000_bib264","doi-asserted-by":"publisher","first-page":"11282","DOI":"10.1073\/PNAS.90.23.11282","article-title":"Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease","volume":"90","author":"U\u00e9da","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024122414085603000_bib265","doi-asserted-by":"publisher","DOI":"10.3389\/conf.fnins.2018.95.00102","article-title":"Increased endosomal microautophagy reduces Tau driven synaptic dysfunction","volume":"12","author":"Uytterhoeven","year":"2018","journal-title":"Front. Neurosci."},{"key":"2024122414085603000_bib266","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cell.2011.02.039","article-title":"Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins","volume":"145","author":"Uytterhoeven","year":"2011","journal-title":"Cell"},{"key":"2024122414085603000_bib267","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.neuron.2015.10.012","article-title":"Hsc70-4 deforms membranes to promote synaptic protein turnover by endosomal microautophagy","volume":"88","author":"Uytterhoeven","year":"2015","journal-title":"Neuron"},{"key":"2024122414085603000_bib268","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/J.JMB.2009.03.021","article-title":"The first N-terminal amino acids of \u03b1-synuclein are essential for \u03b1-helical structure formation in vitro and membrane binding in yeast","volume":"389","author":"Vamvaca","year":"2009","journal-title":"J. Mol. Biol."},{"key":"2024122414085603000_bib269","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1001\/ARCHNEUR.1970.00480210017002","article-title":"Pathological findings in idiopathic orthostatic hypotension. Its relationship with Parkinson\u2019s disease","volume":"22","author":"Vanderhaeghen","year":"1970","journal-title":"Arch. Neurol."},{"key":"2024122414085603000_bib270","doi-asserted-by":"publisher","first-page":"9364","DOI":"10.1523\/JNEUROSCI.4787-13.2014","article-title":"Synucleins regulate the kinetics of synaptic vesicle endocytosis","volume":"34","author":"Vargas","year":"2014","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib271","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899084","article-title":"Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction","volume":"37","author":"Vaz-Silva","year":"2018","journal-title":"EMBO J."},{"key":"2024122414085603000_bib272","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ijbiomac.2019.04.120","article-title":"Regulation of neuronal microtubule dynamics by tau: Implications for tauopathies","volume":"133","author":"Venkatramani","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"2024122414085603000_bib273","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0092-8674(02)00688-8","article-title":"Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release","volume":"109","author":"Verstreken","year":"2002","journal-title":"Cell"},{"key":"2024122414085603000_bib274","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/S41531-022-00423-7","article-title":"Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson\u2019s disease in midbrain dopaminergic neurons","volume":"8","author":"Virdi","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"key":"2024122414085603000_bib275","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/s41467-020-15701-2","article-title":"Spread of pathological tau proteins through communicating neurons in human Alzheimer\u2019s disease","volume":"11","author":"Vogel","year":"2020","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib276","doi-asserted-by":"publisher","first-page":"4010","DOI":"10.1091\/MBC.E14-02-0741","article-title":"Formation of \u03b1-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes","volume":"25","author":"Volpicelli-Daley","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"2024122414085603000_bib277","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/J.NEURON.2011.08.033","article-title":"Exogenous \u03b1-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death","volume":"72","author":"Volpicelli-Daley","year":"2011","journal-title":"Neuron"},{"key":"2024122414085603000_bib278","doi-asserted-by":"publisher","first-page":"ar10","DOI":"10.1091\/MBC.E23-07-0269","article-title":"Excess phosphoserine-129 \u03b1-synuclein induces synaptic vesicle trafficking and declustering defects at a vertebrate synapse","volume":"35","author":"Wallace","year":"2024","journal-title":"Mol. Biol. Cell"},{"key":"2024122414085603000_bib279","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/s41556-024-01456-1","article-title":"VAMP2 chaperones \u03b1-synuclein in synaptic vesicle co-condensates","volume":"26","author":"Wang","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"2024122414085603000_bib280","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1016\/J.CUB.2014.08.027","article-title":"\u03b1-synuclein multimers cluster synaptic vesicles and attenuate recycling","volume":"24","author":"Wang","year":"2014","journal-title":"Curr. Biol."},{"key":"2024122414085603000_bib281","doi-asserted-by":"publisher","first-page":"180185","DOI":"10.1038\/sdata.2018.185","article-title":"The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer\u2019s disease","volume":"5","author":"Wang","year":"2018","journal-title":"Sci. Data"},{"key":"2024122414085603000_bib282","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jns.2019.02.022","article-title":"Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP\/PS1 mouse","volume":"399","author":"Wang","year":"2019","journal-title":"J. Neurol. Sci."},{"key":"2024122414085603000_bib283","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.4103\/1673-5374.363831","article-title":"Targeting chaperone-mediated autophagy for Parkinson\u2019s disease therapy","author":"Wang","year":"2022","journal-title":"Neural Regen. Res."},{"key":"2024122414085603000_bib284","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1002\/alz.13065","article-title":"Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer\u2019s disease and beyond","volume":"19","author":"Webber","year":"2023","journal-title":"Alzheimers Dement."},{"key":"2024122414085603000_bib285","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798049","article-title":"Tau protein liquid-liquid phase separation can initiate tau aggregation","volume":"37","author":"Wegmann","year":"2018","journal-title":"EMBO J."},{"key":"2024122414085603000_bib286","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1074\/jbc.M112.418871","article-title":"Monomeric synucleins generate membrane curvature","volume":"288","author":"Westphal","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib287","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1042\/ETLS20190176","article-title":"Therapeutics-how to treat phase separation-associated diseases","volume":"4","author":"Wheeler","year":"2020","journal-title":"Emerg. Top. Life Sci."},{"key":"2024122414085603000_bib288","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1083\/JCB.201003122","article-title":"\u03b1-Synuclein impairs macroautophagy: Implications for Parkinson\u2019s disease","volume":"190","author":"Winslow","year":"2010","journal-title":"J. Cell Biol."},{"key":"2024122414085603000_bib289","doi-asserted-by":"publisher","first-page":"1181804","DOI":"10.3389\/fnins.2023.1181804","article-title":"Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation","volume":"17","author":"Xia","year":"2023","journal-title":"Front. Neurosci."},{"key":"2024122414085603000_bib290","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13024-021-00460-5","article-title":"\u201cDon\u2019t phos over tau\u201d: Recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer\u2019s disease and other tauopathies","volume":"16","author":"Xia","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"2024122414085603000_bib291","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0005515","article-title":"Abberant \u03b1-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy","volume":"4","author":"Xilouri","year":"2009","journal-title":"PLoS One"},{"key":"2024122414085603000_bib292","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41531-022-00361-4","article-title":"Harmol promotes \u03b1-synuclein degradation and improves motor impairment in Parkinson\u2019s models via regulating autophagy-lysosome pathway","volume":"8","author":"Xu","year":"2022","journal-title":"NPJ Parkinson\u2019s Dis."},{"key":"2024122414085603000_bib293","doi-asserted-by":"publisher","first-page":"4408","DOI":"10.1523\/JNEUROSCI.3627-15.2016","article-title":"\u03b1-Synuclein mutation inhibits endocytosis at mammalian central nerve terminals","volume":"36","author":"Xu","year":"2016","journal-title":"J. Neurosci."},{"key":"2024122414085603000_bib308","doi-asserted-by":"publisher","first-page":"107971","DOI":"10.1016\/j.jbc.2024.107971","article-title":"RNA G-quadruplexes and calcium ions synergistically induce Tau phase transition in vitro","volume":"300","author":"Yabuki","year":"2024","journal-title":"J. Biol. Chem."},{"key":"2024122414085603000_bib295","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.semcdb.2018.05.005","article-title":"The interaction of \u03b1-synuclein and tau: A molecular conspiracy in neurodegeneration?","volume":"99","author":"Yan","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"2024122414085603000_bib296","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03867-x","article-title":"Complicated role of post-translational modification and protease-cleaved fragments of tau in Alzheimer\u2019s disease and other tauopathies","author":"Yang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"2024122414085603000_bib297","doi-asserted-by":"publisher","first-page":"R628","DOI":"10.1016\/j.cub.2016.05.025","article-title":"Common and divergent mechanisms in developmental neuronal remodeling and dying back neurodegeneration","volume":"26","author":"Yaron","year":"2016","journal-title":"Curr. Biol."},{"key":"2024122414085603000_bib298","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.neuroscience.2006.12.028","article-title":"Extensive nuclear localization of \u03b1-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody","volume":"145","author":"Yu","year":"2007","journal-title":"Neuroscience"},{"key":"2024122414085603000_bib299","doi-asserted-by":"publisher","first-page":"736","DOI":"10.2353\/AJPATH.2009.080928","article-title":"Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein","volume":"175","author":"Yu","year":"2009","journal-title":"Am. J. Pathol."},{"key":"2024122414085603000_bib300","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1242\/DMM.028738","article-title":"The role of Ca2+ signaling in Parkinson\u2019s disease","volume":"10","author":"Zaichick","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"2024122414085603000_bib301","doi-asserted-by":"publisher","first-page":"1145939","DOI":"10.3389\/FNEUR.2023.1145939\/BIBTEX","article-title":"Tau-PET imaging in Parkinson\u2019s disease: A systematic review and meta-analysis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Neurol."},{"key":"2024122414085603000_bib302","doi-asserted-by":"publisher","first-page":"662242","DOI":"10.3389\/FNINS.2021.662242\/BIBTEX","article-title":"Glycolytic metabolism, brain resilience, and Alzheimer\u2019s disease","volume":"15","author":"Zhang","year":"2021","journal-title":"Front. Neurosci."},{"key":"2024122414085603000_bib303","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13024-022-00533-z","article-title":"Tauopathies: New perspectives and challenges","volume":"17","author":"Zhang","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"2024122414085603000_bib304","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.3390\/jcm12051883","article-title":"The potential roles of exosomes carrying APP and tau cleavage products in Alzheimer\u2019s disease","volume":"12","author":"Zhao","year":"2023","journal-title":"J. Clin. Med."},{"key":"2024122414085603000_bib305","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1016\/j.neurobiolaging.2009.11.019","article-title":"LRRK2 variant associated with Alzheimer\u2019s disease","volume":"32","author":"Zhao","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"2024122414085603000_bib306","doi-asserted-by":"publisher","first-page":"15295","DOI":"10.1038\/ncomms15295","article-title":"Tau association with synaptic vesicles causes presynaptic dysfunction","volume":"8","author":"Zhou","year":"2017","journal-title":"Nat. Commun."},{"key":"2024122414085603000_bib307","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0184040","article-title":"Proteasome impairment by \u03b1-synuclein","volume":"12","author":"Zondler","year":"2017","journal-title":"PLoS One"}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202409104\/1936929\/jcb_202409104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202409104\/1936929\/jcb_202409104.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T09:09:32Z","timestamp":1735031372000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/224\/2\/e202409104\/277182\/Synaptic-sabotage-How-Tau-and-Synuclein-undermine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":307,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,3]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.202409104","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,24]]},"article-number":"e202409104"}}