{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:42:57Z","timestamp":1792676577357,"version":"4.5.0"},"reference-count":46,"publisher":"Rockefeller University Press","issue":"11","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA284090"],"award-info":[{"award-number":["U01CA284090"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54CA268083"],"award-info":[{"award-number":["U54CA268083"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA006973"],"award-info":[{"award-number":["P30CA006973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM103853"],"award-info":[{"award-number":["R01GM103853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL165729"],"award-info":[{"award-number":["R01HL165729"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM151746"],"award-info":[{"award-number":["R01GM151746"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99HL168075"],"award-info":[{"award-number":["K99HL168075"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM136577"],"award-info":[{"award-number":["T32GM136577"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM149329"],"award-info":[{"award-number":["R35GM149329"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23POST1057352"],"award-info":[{"award-number":["23POST1057352"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002651","name":"Barth Syndrome Foundation","doi-asserted-by":"publisher","award":["828058"],"award-info":[{"award-number":["828058"]}],"id":[{"id":"10.13039\/100002651","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hope Scarves Foundation"},{"DOI":"10.13039\/100016460","name":"Jayne Koskinas Ted Giovanis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","award":["BCRF-25-048"],"award-info":[{"award-number":["BCRF-25-048"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11,2]]},"abstract":"<jats:p>E-cadherin suppresses invasion and promotes metastasis in invasive ductal breast cancer, through suppression of reactive oxygen species (ROS). We sought to determine the cellular source of apoptosis-inducing ROS and to identify the domains of E-cadherin that are essential for cancer cell survival. Inhibition of mitochondria-derived ROS was sufficient to rescue cell death following E-cadherin deletion, in both 3D colony formation and in vivo metastasis assays. We next generated Cdh1 constructs by mutating amino acids or deleting domains, then tested their ability to rescue colony formation in E-cadherin\u2013deleted cells. Surprisingly, E-cadherin constructs in which the extracellular domains were deleted, adhesion was compromised, or catenin interactions were blocked could rescue elevated mitochondrial ROS and 3D colony formation. Conversely, a construct lacking the cytoplasmic domain was unable to rescue ROS or cell death. Our findings reveal that E-cadherin\u2019s ability to regulate mitochondrial ROS, cancer cell survival, and metastatic outgrowth is separable from its role in intercellular adhesion.<\/jats:p>","DOI":"10.1083\/jcb.202507222","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:17:28Z","timestamp":1792675048000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Nonadhesive functions of E-cadherin promote cancer cell survival and metastasis"],"prefix":"10.1083","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4695-9674","authenticated-orcid":true,"given":"Ryan L.","family":"Huizar","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 1 Department of Cell Biology, , Baltimore, MD,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine 2 Department of Oncology, , Baltimore, MD,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"Giovanis Institute for Translational Cell Biology, The Johns Hopkins University School of Medicine 3 , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3868-4438","authenticated-orcid":true,"given":"James V.","family":"McCann","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 1 Department of Cell Biology, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0590-3156","authenticated-orcid":true,"given":"Malak","family":"Amer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 1 Department of Cell Biology, , Baltimore, MD,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine 2 Department of Oncology, , Baltimore, MD,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"Giovanis Institute for Translational Cell Biology, The Johns Hopkins University School of Medicine 3 , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4988-4989","authenticated-orcid":true,"given":"Beza","family":"Woldemeskel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 1 Department of Cell Biology, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-6620","authenticated-orcid":true,"given":"Daisuke","family":"Murata","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 1 Department of Cell Biology, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5260-3848","authenticated-orcid":true,"given":"Nanami","family":"Senoo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"Pharmacology and Therapeutics, Mitochondrial Phospholipid Research Center, Johns Hopkins University School of Medicine 4 Department of Physiology, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-2402","authenticated-orcid":true,"given":"Abhijit","family":"Deb Roy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kzs4y22","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Connecticut School of Medicine 5 Center for Cell Analysis and Modeling and Department of Cell Biology, , Farmington, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-3750","authenticated-orcid":true,"given":"Benjamin C.","family":"Orsburn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"Organ Pathobiology and Therapeutics Institute, The University of Pittsburgh 6 , Pittsburgh, PA,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 7 Department of Pharmacology and Molecular Sciences, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-1623","authenticated-orcid":true,"given":"Steven M.","family":"Claypool","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"Pharmacology and Therapeutics, Mitochondrial Phospholipid Research Center, Johns Hopkins University School of Medicine 4 Department of Physiology, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-3929","authenticated-orcid":true,"given":"Hiromi","family":"Sesaki","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 1 Department of Cell Biology, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-9135","authenticated-orcid":true,"given":"Miho","family":"Iijima","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 1 Department of Cell Biology, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-3824","authenticated-orcid":true,"given":"Namandj\u00e9 N.","family":"Bumpus","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"Organ Pathobiology and Therapeutics Institute, The University of Pittsburgh 6 , Pittsburgh, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-7624","authenticated-orcid":true,"given":"Takanari","family":"Inoue","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 1 Department of Cell Biology, , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1964-0740","authenticated-orcid":true,"given":"Andrew J.","family":"Ewald","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"The Johns Hopkins University School of Medicine 1 Department of Cell Biology, , Baltimore, MD,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine 2 Department of Oncology, , Baltimore, MD,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/037zgn354","id-type":"ROR","asserted-by":"publisher"}],"name":"Giovanis Institute for Translational Cell Biology, The Johns Hopkins University School of Medicine 3 , Baltimore, MD,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"2026102209170620900_bib1","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.cell.2014.07.013","article-title":"Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis","volume":"158","author":"Aceto","year":"2014","journal-title":"Cell"},{"key":"2026102209170620900_bib2","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.5114\/aoms.2015.53964","article-title":"Retrospective evaluation of histopathological examinations in invasive ductal breast cancer of no special type: An analysis of 691 patients","volume":"13","author":"Badowska-Kozakiewicz","year":"2017","journal-title":"Arch. Med. Sci."},{"key":"2026102209170620900_bib3","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"2026102209170620900_bib4","doi-asserted-by":"publisher","first-page":"5054","DOI":"10.3390\/cancers13205054","article-title":"E-Cadherin regulates mitochondrial membrane potential in cancer cells","volume":"13","author":"Begum","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2026102209170620900_bib5","doi-asserted-by":"publisher","first-page":"6107","DOI":"10.1002\/j.1460-2075.1995.tb00301.x","article-title":"E-cadherin is a tumour\/invasion suppressor gene mutated in human lobular breast cancers","volume":"14","author":"Berx","year":"1995","journal-title":"EMBO J."},{"key":"2026102209170620900_bib6","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/bcr309","article-title":"The E-cadherin\/catenin complex: An important gatekeeper in breast cancer tumorigenesis and malignant progression","volume":"3","author":"Berx","year":"2001","journal-title":"Breast Cancer Res."},{"key":"2026102209170620900_bib7","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.tcb.2004.07.007","article-title":"The ins and outs of E-cadherin trafficking","volume":"14","author":"Bryant","year":"2004","journal-title":"Trends Cell Biol."},{"key":"2026102209170620900_bib8","first-page":"2541","article-title":"Temporal progression of metastasis in lung: Cell survival, dormancy, and location dependence of metastatic inefficiency","volume":"60","author":"Cameron","year":"2000","journal-title":"Cancer Res."},{"key":"2026102209170620900_bib9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12307-011-0085-4","article-title":"Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases","volume":"5","author":"Chao","year":"2012","journal-title":"Cancer Microenviron"},{"key":"2026102209170620900_bib10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/1476-4598-9-179","article-title":"Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition","volume":"9","author":"Chao","year":"2010","journal-title":"Mol. Cancer"},{"key":"2026102209170620900_bib11","doi-asserted-by":"publisher","first-page":"E87","DOI":"10.1152\/ajpendo.00457.2019","article-title":"A pipeline for multidimensional confocal analysis of mitochondrial morphology, function, and dynamics in pancreatic \u03b2-cells","volume":"318","author":"Chaudhry","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2026102209170620900_bib12","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1126\/science.aaf6546","article-title":"A collective route to metastasis: Seeding by tumor cell clusters","volume":"352","author":"Cheung","year":"2016","journal-title":"Science"},{"key":"2026102209170620900_bib13","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.cell.2013.11.029","article-title":"Collective invasion in breast cancer requires a conserved basal epithelial program","volume":"155","author":"Cheung","year":"2013","journal-title":"Cell"},{"key":"2026102209170620900_bib14","doi-asserted-by":"publisher","first-page":"E854","DOI":"10.1073\/pnas.1508541113","article-title":"Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters","volume":"113","author":"Cheung","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026102209170620900_bib15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s0968-0004(98)01343-7","article-title":"The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene","volume":"24","author":"Christofori","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"2026102209170620900_bib16","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1002\/(sici)1096-9896(199712)183:4&lt;404::aid-path1148&gt;3.0.co;2-9","article-title":"Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ","volume":"183","author":"De Leeuw","year":"1997","journal-title":"J. Pathol."},{"key":"2026102209170620900_bib17","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ccr.2006.09.013","article-title":"Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis","volume":"10","author":"Derksen","year":"2006","journal-title":"Cancer Cell"},{"key":"2026102209170620900_bib18","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.celrep.2015.12.020","article-title":"Intravital FRAP imaging using an E-cadherin-GFP mouse reveals Disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue","volume":"14","author":"Erami","year":"2016","journal-title":"Cell Rep."},{"key":"2026102209170620900_bib19","first-page":"773","article-title":"Metastasis: Quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine","volume":"45","author":"Fidler","year":"1970","journal-title":"J. Natl. Cancer Inst."},{"key":"2026102209170620900_bib44","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1091\/mbc.e07-12-1287","article-title":"The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells.","volume":"19","author":"Gandre-Babbe","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"2026102209170620900_bib20","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.cell.2023.03.003","article-title":"Metastasis","volume":"186","author":"Gerstberger","year":"2023","journal-title":"Cell"},{"key":"2026102209170620900_bib21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/32918","article-title":"E-cadherin germline mutations in familial gastric cancer","volume":"392","author":"Guilford","year":"1998","journal-title":"Nature"},{"key":"2026102209170620900_bib22","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1128\/mcb.12.3.954-961.1992","article-title":"Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease","volume":"12","author":"Guy","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"2026102209170620900_bib23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41698-019-0092-3","article-title":"Engineered models to parse apart the metastatic cascade","volume":"3","author":"Hapach","year":"2019","journal-title":"NPJ Precis Oncol."},{"key":"2026102209170620900_bib24","doi-asserted-by":"publisher","first-page":"R76","DOI":"10.1186\/gb-2007-8-5-r76","article-title":"Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors","volume":"8","author":"Herschkowitz","year":"2007","journal-title":"Genome Biol."},{"key":"2026102209170620900_bib45","doi-asserted-by":"publisher","first-page":"jcs263640","DOI":"10.1242\/jcs.263640","article-title":"Mitochondrial fission - changing perspectives for future progress","volume":"138","author":"Kamerkar","year":"2025","journal-title":"J. of Cell Sci."},{"key":"2026102209170620900_bib25","doi-asserted-by":"publisher","first-page":"R217","DOI":"10.1186\/bcr651","article-title":"E-cadherin expression in primary carcinomas of the breast and its distant metastases","volume":"5","author":"Kowalski","year":"2003","journal-title":"Breast Cancer Res."},{"key":"2026102209170620900_bib26","doi-asserted-by":"publisher","first-page":"16445","DOI":"10.18632\/oncotarget.14860","article-title":"Prognostic value of reduced E-cadherin expression in breast cancer: A meta-analysis","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"2026102209170620900_bib27","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0002-9440(10)65628-3","article-title":"Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases","volume":"153","author":"Luzzi","year":"1998","journal-title":"Am. J. Pathol."},{"key":"2026102209170620900_bib28","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature17038","article-title":"Metastatic colonization by circulating tumour cells","volume":"529","author":"Massagu\u00e9","year":"2016","journal-title":"Nature"},{"key":"2026102209170620900_bib29","doi-asserted-by":"publisher","first-page":"a028738","DOI":"10.1101\/cshperspect.a028738","article-title":"Integration of cadherin adhesion and cytoskeleton at Adherens junctions","volume":"9","author":"M\u00e8ge","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2026102209170620900_bib30","first-page":"1731","article-title":"Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas","volume":"143","author":"Moll","year":"1993","journal-title":"Am. J. Pathol."},{"key":"2026102209170620900_bib46","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/jb\/mvz106","article-title":"Mitochondrial division, fusion and degradation","volume":"167","author":"Murata","year":"2020","journal-title":"J. Biochem."},{"key":"2026102209170620900_bib31","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1146\/annurev.pharmtox.47.120505.105110","article-title":"Targeting antioxidants to mitochondria by conjugation to lipophilic cations","volume":"47","author":"Murphy","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2026102209170620900_bib32","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1158\/0008-5472.CAN-07-2938","article-title":"Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways","volume":"68","author":"Onder","year":"2008","journal-title":"Cancer Res."},{"key":"2026102209170620900_bib33","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1038\/s41596-020-0335-3","article-title":"Organotypic culture assays for murine and human primary and metastatic-site tumors","volume":"15","author":"Padmanaban","year":"2020","journal-title":"Nat. Protoc."},{"key":"2026102209170620900_bib34","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/s41586-019-1526-3","article-title":"E-cadherin is required for metastasis in multiple models of breast cancer","volume":"573","author":"Padmanaban","year":"2019","journal-title":"Nature"},{"key":"2026102209170620900_bib35","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nrc1370","article-title":"Dissecting the metastatic cascade","volume":"4","author":"Pantel","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"2026102209170620900_bib36","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/32433","article-title":"A causal role for E-cadherin in the transition from adenoma to carcinoma","volume":"392","author":"Perl","year":"1998","journal-title":"Nature"},{"key":"2026102209170620900_bib37","doi-asserted-by":"publisher","first-page":"2005420","DOI":"10.1080\/21688370.2021.2005420","article-title":"Dual role of E-cadherin in cancer cells","volume":"10","author":"Rubtsova","year":"2022","journal-title":"Tissue Barriers"},{"key":"2026102209170620900_bib38","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2026102209170620900_bib39","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1038\/s41467-019-11716-6","article-title":"Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin","volume":"10","author":"Schipper","year":"2019","journal-title":"Nat. Commun."},{"key":"2026102209170620900_bib40","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1083\/jcb.201306088","article-title":"Twist1-induced dissemination preserves epithelial identity and requires E-cadherin","volume":"204","author":"Shamir","year":"2014","journal-title":"J. Cell Biol."},{"key":"2026102209170620900_bib41","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/0955-0674(93)90029-p","article-title":"Cadherins in cancer: Implications for invasion and metastasis","volume":"5","author":"Takeichi","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"2026102209170620900_bib42","doi-asserted-by":"publisher","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell-cell adhesion molecule E-cadherin","volume":"65","author":"van Roy","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"2026102209170620900_bib43","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1074\/mcp.TIR120.002048","article-title":"Fast quantitative analysis of timsTOF PASEF data with MSFragger and IonQuant","volume":"19","author":"Yu","year":"2020","journal-title":"Mol. Cell Proteomics"}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202507222\/2042791\/jcb_202507222.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202507222\/2042791\/jcb_202507222.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:17:30Z","timestamp":1792675050000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/225\/11\/e202507222\/283108\/Nonadhesive-functions-of-E-cadherin-promote-cancer"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11,2]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.202507222","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"article-number":"e202507222"}}