{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:46:08Z","timestamp":1786117568884,"version":"build-2736575974"},"reference-count":61,"publisher":"Rockefeller University Press","issue":"10","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/rupress.org\/pages\/terms102024"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["262652"],"award-info":[{"award-number":["262652"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["221831"],"award-info":[{"award-number":["221831"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["249753"],"award-info":[{"award-number":["249753"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["325305"],"award-info":[{"award-number":["325305"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008730","name":"Norwegian Cancer Society","doi-asserted-by":"publisher","award":["190251"],"award-info":[{"award-number":["190251"]}],"id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:p>BEACH domain\u2013containing proteins (BDCPs) represent a family of large membrane\u2013associated transmembrane cargo adaptors. In the current study, we determined the cryo-EM structure of the full-length typical BDCP NBEAL2, revealing an N-terminal arch-like structure with C-terminal globular domains attached to its convex surface. Using structure-guided deletion mutants and protein chimeras as well as native alternatively spliced isoforms and disease-related point mutants, we show that the N-terminal \u03b1-solenoid\/concanavalin A\u2013like domain assembly of the typical BDCPs NBEAL1, NBEAL2, LYST, ALFY, LRBA, and NBEA functions as a modular membrane recruitment domain. We report that gray platelet syndrome\u2013associated single aa mutations L388P or E643V within the membrane recruitment domain of NBEAL2 disrupt its membrane targeting in stably transfected cells, highlighting a potential structure-function mechanism by which failed membrane recruitment cause gray platelet syndrome or other BDCPs-related diseases.<\/jats:p>","DOI":"10.1083\/jcb.202510098","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:21:04Z","timestamp":1782973264000},"update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Characterizing the membrane recruitment domain of BDCPs and its role in gray platelet syndrome"],"prefix":"10.1083","volume":"225","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7278-0454","authenticated-orcid":true,"given":"Anette Kathinka","family":"Dahl","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo 1 , Oslo,","place":["Norway"]},{"id":[{"id":"https:\/\/ror.org\/00j9c2840","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Cancer Research, Oslo University Hospital 2 Department of Molecular Cell Biology, , Oslo,","place":["Norway"]},{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Basic Medical Sciences, University of Oslo 3 Department of Molecular Medicine, , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9106-9358","authenticated-orcid":true,"given":"Daniel","family":"Mann","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02nv7yv05","id-type":"ROR","asserted-by":"publisher"}],"name":"Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons: ER-C-3: Structural Biology, Forschungszentrum J\u00fclich 4 , J\u00fclich,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-3276","authenticated-orcid":true,"given":"Alf H\u00e5kon","family":"Lystad","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo 1 , Oslo,","place":["Norway"]},{"id":[{"id":"https:\/\/ror.org\/00j9c2840","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Cancer Research, Oslo University Hospital 2 Department of Molecular Cell Biology, , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-5143","authenticated-orcid":true,"given":"Carsten","family":"Sachse","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02nv7yv05","id-type":"ROR","asserted-by":"publisher"}],"name":"Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons: ER-C-3: Structural Biology, Forschungszentrum J\u00fclich 4 , J\u00fclich,","place":["Germany"]},{"name":"Heinrich Heine University, Universit\u00e4tsstr. 1 5 Department of Biology, , D\u00fcsseldorf,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-7057","authenticated-orcid":true,"given":"Anne","family":"Simonsen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo 1 , Oslo,","place":["Norway"]},{"id":[{"id":"https:\/\/ror.org\/00j9c2840","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Cancer Research, Oslo University Hospital 2 Department of Molecular Cell Biology, , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-2445","authenticated-orcid":true,"given":"Serhiy","family":"Pankiv","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01xtthb56","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo 1 , Oslo,","place":["Norway"]},{"id":[{"id":"https:\/\/ror.org\/00j9c2840","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Cancer Research, Oslo University Hospital 2 Department of Molecular Cell Biology, , Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"2026080610043197200_bib1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.jaci.2012.05.043","article-title":"LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency","volume":"130","author":"Alangari","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026080610043197200_bib2","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/ng.885","article-title":"Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome","volume":"43","author":"Albers","year":"2011","journal-title":"Nat. Genet."},{"key":"2026080610043197200_bib3","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5189","article-title":"Diversity and structural-functional insights of alpha-solenoid proteins","volume":"33","author":"Arr\u00edas","year":"2024","journal-title":"Protein Sci."},{"key":"2026080610043197200_bib4","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1126\/science.abj8754","article-title":"Accurate prediction of protein structures and interactions using a three-track neural network","volume":"373","author":"Baek","year":"2021","journal-title":"Science"},{"key":"2026080610043197200_bib5","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202309057","article-title":"Faa1 membrane binding drives positive feedback in autophagosome biogenesis via fatty acid activation","volume":"223","author":"Baumann","year":"2024","journal-title":"J. Cell Biol."},{"key":"2026080610043197200_bib6","doi-asserted-by":"publisher","first-page":"4528","DOI":"10.1038\/s41598-020-61352-0","article-title":"NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease","volume":"10","author":"Bindesb\u00f8ll","year":"2020","journal-title":"Sci. Rep."},{"key":"2026080610043197200_bib7","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1093\/bioinformatics\/btp151","article-title":"A concanavalin A-like lectin domain in the CHS1\/LYST protein, shared by members of the BEACH family","volume":"25","author":"Burgess","year":"2009","journal-title":"Bioinformatics"},{"key":"2026080610043197200_bib8","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.1021\/pr800540h","article-title":"The PI(3,5)P2 and PI(4,5)P2 interactomes","volume":"7","author":"Catimel","year":"2008","journal-title":"J. Proteome Res."},{"key":"2026080610043197200_bib9","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1093\/protein\/14.11.857","article-title":"Structural similarity and functional diversity in proteins containing the legume lectin fold","volume":"14","author":"Chandra","year":"2001","journal-title":"Protein Eng."},{"key":"2026080610043197200_bib10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039975","article-title":"NBEAL2 gene mutations do not always lead to gray platelet syndrome: A case report","volume":"103","author":"Chen","year":"2024","journal-title":"Medicine"},{"key":"2026080610043197200_bib11","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.1083\/jcb.201707172","article-title":"Segregation in the Golgi complex precedes export of endolysosomal proteins in distinct transport carriers","volume":"216","author":"Chen","year":"2017","journal-title":"J. Cell Biol."},{"key":"2026080610043197200_bib12","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/tra.12069","article-title":"The BEACH is hot: A LYST of emerging roles for BEACH-domain containing proteins in human disease","volume":"14","author":"Cullinane","year":"2013","journal-title":"Traffic"},{"key":"2026080610043197200_bib13","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100554","article-title":"Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy","volume":"38","author":"Dudley","year":"2019","journal-title":"EMBO J."},{"key":"2026080610043197200_bib14","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1016\/j.molcel.2021.04.019","article-title":"TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation","volume":"81","author":"Fitzian","year":"2021","journal-title":"Mol. Cell"},{"key":"2026080610043197200_bib15","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201912098","article-title":"A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy","volume":"219","author":"Fracchiolla","year":"2020","journal-title":"J. Cell Biol."},{"key":"2026080610043197200_bib16","doi-asserted-by":"publisher","first-page":"14873","DOI":"10.1021\/bi049498y","article-title":"Crystal structure of the PH\u2212 BEACH domains of human LRBA\/BGL","volume":"43","author":"Gebauer","year":"2004","journal-title":"Biochemistry"},{"key":"2026080610043197200_bib17","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"Gibson","year":"2009","journal-title":"Nat. Methods"},{"key":"2026080610043197200_bib18","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00018-016-2319-6","article-title":"Metazoan evolution of the armadillo repeat superfamily","volume":"74","author":"Gul","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"2026080610043197200_bib19","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1101\/gr.126110.111","article-title":"Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred","volume":"21","author":"Gulsuner","year":"2011","journal-title":"Genome Res."},{"key":"2026080610043197200_bib20","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/ng.883","article-title":"NBEAL2 is mutated in gray platelet syndrome and is required for biogenesis of platelet \u03b1-granules","volume":"43","author":"Gunay-Aygun","year":"2011","journal-title":"Nat. Genet."},{"key":"2026080610043197200_bib21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature25502","article-title":"The cryo-electron microscopy structure of huntingtin","volume":"555","author":"Guo","year":"2018","journal-title":"Nature"},{"key":"2026080610043197200_bib22","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1101\/gr.143000","article-title":"DNA cloning using in vitro site-specific recombination","volume":"10","author":"Hartley","year":"2000","journal-title":"Genome Res."},{"key":"2026080610043197200_bib23","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1038\/s41598-017-04433-x","article-title":"Whole exome sequencing to identify genetic variants associated with raised atherosclerotic lesions in young persons","volume":"7","author":"Hixson","year":"2017","journal-title":"Sci. Rep."},{"key":"2026080610043197200_bib24","doi-asserted-by":"publisher","first-page":"4785","DOI":"10.1093\/emboj\/cdf502","article-title":"Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain","volume":"21","author":"Jogl","year":"2002","journal-title":"EMBO J."},{"key":"2026080610043197200_bib25","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"2026080610043197200_bib26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005919","article-title":"ALFY-controlled DVL3 autophagy regulates wnt signaling, determining human brain size","volume":"12","author":"Kadir","year":"2016","journal-title":"PLoS Genet."},{"key":"2026080610043197200_bib27","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/ng.884","article-title":"Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome","volume":"43","author":"Kahr","year":"2011","journal-title":"Nat. Genet."},{"key":"2026080610043197200_bib28","doi-asserted-by":"publisher","first-page":"36464","DOI":"10.1074\/jbc.M503672200","article-title":"Huntingtin associates with acidic phospholipids at the plasma membrane","volume":"280","author":"Kegel","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2026080610043197200_bib29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007148","article-title":"Highly sensitive detection of individual HEAT and ARM repeats with HHpred and COACH","volume":"4","author":"Kippert","year":"2009","journal-title":"PLoS One"},{"key":"2026080610043197200_bib30","article-title":"Cerebellar Ataxia, impaired intellectual development, and dysequilibrium syndrome 2; CAMRQ2","author":"Kniffin","year":"2006"},{"key":"2026080610043197200_bib31","article-title":"Immunodeficiency, common variable, 8, with autoimmunity; CVID8","author":"Kniffin","year":"2012"},{"key":"2026080610043197200_bib32","article-title":"Microcephaly 18, primary, autosomal dominant; MCPH18","author":"Kniffin","year":"2017"},{"key":"2026080610043197200_bib33","article-title":". Neurodevelopmental disorder with or without early-onset generalized epilepsy; NEDEGE","author":"Kniffin","year":"2021"},{"key":"2026080610043197200_bib34","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/s0968-0004(00)01667-4","article-title":"When protein folding is simplified to protein coiling: The continuum of solenoid protein structures","volume":"25","author":"Kobe","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"2026080610043197200_bib35","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1136\/annrheumdis-2017-212149","article-title":"Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis","volume":"77","author":"Kochi","year":"2018","journal-title":"Ann Rheum Dis."},{"key":"2026080610043197200_bib36","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/biot.201400821","article-title":"Optimized sleeping beauty transposons rapidly generate stable transgenic cell lines","volume":"10","author":"Kowarz","year":"2015","journal-title":"Biotechnol. J."},{"key":"2026080610043197200_bib37","doi-asserted-by":"publisher","first-page":"37011","DOI":"10.1074\/jbc.M007296200","article-title":"HEAT repeats mediate plasma membrane localization of Tor2p in yeast.","volume":"275","author":"Kunz","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2026080610043197200_bib38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1083\/jcb.127.1.29","article-title":"HVEM tomography of the trans-Golgi network: Structural insights and identification of a lace-like vesicle coat","volume":"127","author":"Ladinsky","year":"1994","journal-title":"J. Cell Biol."},{"key":"2026080610043197200_bib39","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1093\/brain\/awz198","article-title":"Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size","volume":"142","author":"Le Duc","year":"2019","journal-title":"Brain"},{"key":"2026080610043197200_bib40","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.ajhg.2012.04.015","article-title":"Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity","volume":"90","author":"Lopez-Herrera","year":"2012","journal-title":"Am J. Hum. Genet."},{"key":"2026080610043197200_bib41","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1093\/rheumatology\/keae183","article-title":"The clinical relevance of WDFY4 in autoimmune diseases in diverse ancestral populations","volume":"63","author":"Lyu","year":"2024","journal-title":"Rheumatology"},{"key":"2026080610043197200_bib42","article-title":"Chediak-Higashi Syndrome; CHS","author":"McKusick","year":"1986"},{"key":"2026080610043197200_bib43","article-title":"Gray platelet syndrome; GPS","author":"McKusick","year":"1987"},{"key":"2026080610043197200_bib44","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1126\/science.1178817","article-title":"A simple cipher governs DNA recognition by TAL effectors","volume":"326","author":"Moscou","year":"2009","journal-title":"Science"},{"key":"2026080610043197200_bib45","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1002\/ana.25350","article-title":"NBEA: Developmental disease gene with early generalized epilepsy phenotypes","volume":"84","author":"Mulhern","year":"2018","journal-title":"Ann. Neurol."},{"key":"2026080610043197200_bib46","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/ng1196-307","article-title":"Identification and mutation analysis of the complete gene for Chediak\u2013Higashi syndrome","volume":"14","author":"Nagle","year":"1996","journal-title":"Nat. Genet."},{"key":"2026080610043197200_bib47","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202408173","article-title":"BEACH domain proteins function as cargo-sorting adaptors in secretory and endocytic pathways","volume":"223","author":"Pankiv","year":"2024","journal-title":"J. Cell Biol."},{"key":"2026080610043197200_bib48","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"2026080610043197200_bib49","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1083\/jcb.148.1.45","article-title":"Correlative light-electron microscopy reveals the tubular-saccular ultrastructure of carriers operating between Golgi apparatus and plasma membrane","volume":"148","author":"Polishchuk","year":"2000","journal-title":"J. Cell Biol."},{"key":"2026080610043197200_bib50","doi-asserted-by":"publisher","first-page":"10678","DOI":"10.1038\/s41598-024-60257-6","article-title":"LRBA, a BEACH protein mutated in human immune deficiency, is widely expressed in epithelia, exocrine and endocrine glands, and neurons","volume":"14","author":"Roussa","year":"2024","journal-title":"Sci. Rep."},{"key":"2026080610043197200_bib51","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2026080610043197200_bib52","doi-asserted-by":"publisher","first-page":"4239","DOI":"10.1242\/jcs.01287","article-title":"Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes","volume":"117","author":"Simonsen","year":"2004","journal-title":"J. Cell Sci."},{"key":"2026080610043197200_bib53","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1182\/blood.2019004776","article-title":"Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome","volume":"136","author":"Sims","year":"2020","journal-title":"Blood"},{"key":"2026080610043197200_bib54","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(12)60436-7","article-title":"Rare coding mutations and risk for early-onset myocardial infarction: An exome sequencing study of &gt;2,000 cases and controls","volume":"59","author":"Stitziel","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"2026080610043197200_bib55","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00251-020-01182-6","article-title":"The immune system of jawless vertebrates: Insights into the prototype of the adaptive immune system","volume":"73","author":"Sutoh","year":"2021","journal-title":"Immunogenetics"},{"key":"2026080610043197200_bib56","doi-asserted-by":"publisher","first-page":"jcs259138","DOI":"10.1242\/jcs.259138","article-title":"ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration","volume":"135","author":"S\u00f8reng","year":"2022","journal-title":"J. Cell Sci."},{"key":"2026080610043197200_bib57","doi-asserted-by":"publisher","first-page":"A182","DOI":"10.17815\/jlsrf-7-182","article-title":"JURECA: Data centric and booster modules implementing the modular supercomputing architecture at J\u00fclich supercomputing centre","volume":"7","author":"Th\u00f6rnig","year":"2021","journal-title":"J. Large-Scale Research Facilities"},{"key":"2026080610043197200_bib58","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41301","article-title":"The spatial separation of processing and transport functions to the interior and periphery of the Golgi stack","volume":"7","author":"Tie","year":"2018","journal-title":"Elife"},{"key":"2026080610043197200_bib59","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1083\/jcb.200712028","article-title":"Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores","volume":"181","author":"Tighe","year":"2008","journal-title":"J. Cell Biol."},{"key":"2026080610043197200_bib60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000841","article-title":"Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus","volume":"6","author":"Yang","year":"2010","journal-title":"PLoS Genet."},{"key":"2026080610043197200_bib61","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.3390\/ijms15022712","article-title":"E26 transformation-specific-1 (ETS1) and WDFY family member 4 (WDFY4) polymorphisms in Chinese patients with rheumatoid arthritis","volume":"15","author":"Zhang","year":"2014","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202510098\/2039238\/jcb_202510098.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/doi\/10.1083\/jcb.202510098\/2039238\/jcb_202510098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:06:03Z","timestamp":1786025163000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/225\/10\/e202510098\/282890\/Characterizing-the-membrane-recruitment-domain-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,5]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.202510098","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"article-number":"e202510098"}}